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Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated.Migraine is a neurovascular disorder, recognized as the second most disabling disease. Nevertheles
Innovation in retailing is under-investigated in academia and yet highly relevant in practice given the current changes in the retail landscape. Although retailing is often characterised by a dynamic and highly competitive environment, retail organizations are not often considered as “innovative,” at least when compared with manufacturing industries or when using existing innovation frameworks in
During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has beco
Despite the fact that Cesarean section (C-section) is the most commonly performed surgery in a number of industrialized countries, little is known about the long-term consequences for the mothers and children involved. In this study, I use a sample of high-risk births—namely, breech births, in which the fetus is presented with its head upward instead of downward—to study the causal effect of C-sec
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:- To assess the effect of preoperative alcohol cessation interventions on the rate of postoperative complications in hazardous drinkers- To assess the effect of preoperative alcohol cessation interventions for hazardous drinkers on alcohol use in the postoperative period and longer term
Notwithstanding its many successes since 1945, the project of European integration currently faces major difficulties, from financial crises and mass immigration to the impending departure of the UK from the European Union. At the same time, these challenges have spurred civil society organizations within and across Europe, revealing a shared public sphere in which citizens can mobilize around ref
The use of variable-length genomes in evolutionary computation has applications in optimisation when the size of the search space is unknown, and provides a unique environment to study the evolutionary dynamics of genome structure. Here, we revisit crossover for linear genomes of variable length, identifying two crucial attributes of successful recombination algorithms: the ability to retain homol
Background: Faculty development roles are changing within organizations (Gibbs 2013). In previous research the expanding role in organizations as “Coming in from the margins” was described (Schroeder 2011). We studied how different levels of participation evolved within a research intense faculty with a complex organization and various educational programs.Summary of Work: The Centre was establish
Epidemiologic data on pleural mesothelioma are scarce on regional and occupational time trends, which would monitor the effects of changes in exposure to asbestos. We aim to characterize time trends, regional, socioeconomic, and occupational risk factors for pleural mesothelioma in Sweden in the years from 1961 to 1998. The Swedish Family-Cancer Database was used to identify patients with pleural
Epidemiologic data on peritoneal mesothelioma are scarce but exposure to asbestos is an identified risk factor. To characterize the disease, time trends, age-incidence relationships, and occupational risk factors for peritoneal mesothelioma were studied based on the Swedish Family-Database covering years 1961 to 1998. Peritoneal mesothelioma is a rare disease and only 96 male and 113 female cases
Many of today’s health care facilities are outdated and no longer efficiently support processes. The various development trends in changing health care services seem to support more frequent use of modular facilities. Modular facilities and their development, however, face the challenge of combining a customized, user-centric design for special customer needs with the rapid delivery of prefabricat
We explore the gravitational instability of clumpy and turbulent gas discs, taking into account the Larson-type scaling laws observed in giant molecular clouds (GMCs) and H i, as well as more general scaling relations. This degree of freedom is of special interest in view of the coming high-z interstellar medium surveys and is thus potentially important for understanding the dynamical effects of t
The aim with this paper is to examine how different GIS-based visualization methods can be applied and come to practical uses in the emergency service’s fire preventive work. These techniques motivate and facilitate various forms of fire prevention such as selection of areas or neighborhoods, blocks or buildings before home visits, identification and targeting of different risk groups and customiz
The aim is to illustrate how web marketing frame commercial baby food as a value-adding part of weaning practice and discuss how various ways of framing relate to contemporary mothering ideals. Drawing on “practice” and “frame analysis,” we illustrate how four baby food producers’ web marketing frame commercial baby food and weaning as “medical,” “fun” or “convenient.” The analysis shows that the
Car-sharing systems with electric vehicles are an alternative to reduce commuting times in big cities and also to mitigate air pollution. Car-sharing exists in 1100 cities around the world. These systems have had positive effects in the cities, replacing between 9 and 23 private vehicles for each car. This document proposes a public car-sharing system for Bogotá. The article focuses on the design
Kärn- och elektrondynamik i atomer och molekyler är grunden för många fysiska processer och kemiska reaktioner. Ofta händer denna dynamik på tidsskalor som är så korta att de kallas ultrasnabba.För att studera ultrasnabba fenomen behövs tekniker som pump-prob-experiment med ultrasnabba ljuspulser. För att dessa experiment ska lyckas måste ljuspulsernas egenskaper noga studeras och styras för att dNuclear and electronic dynamics in atoms and molecules are the foundation of many physical processes and chemical reactions. Often, these dynamics take place on timescales so much shorter than those commonly encountered that they are called ultrafast. In order to study ultrafast phenomena, time-resolved techniques such as pump-probe experiments, involving ultrafast light pulses, are necessa
Throughout time, communities have adapted to changes in their environment and, in doing so, have addressed risksthat threaten the things they value. The need to adapt is considered more urgent now than ever, notably given thecurrent focus on climate risk. Typically, adaptation is presented as a solution to reduce such risks. This is particularlythe case for Landlocked Developing Countries and Smal
