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PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS: Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorph
Reviewing the information systems (IS) literature shows the prevalence of studies claiming to exploit the grounded theory (GT) method. However, most of these studies follow an objectivist approach to GT. This manuscript addresses another recognized yet rarely used GT approach in IS: constructivist. The importance of IS constructivist research is briefly explained. This is followed with a recapitul
The radioactive decay of 238U and 232Th has recently been used to determine ages for some of the oldest stars in the Universe. This has highlighted the need for accurate observational constraints on production models for the heaviest r-process elements which might serve as stable references, notably osmium and iridium. In order to provide a firmer basis for the observed abund
Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recov
Popular Abstract in Swedish Byggnadsprestanda – Metoder för förbättrad prediktering och verifiering av energianvändning och inneklimat Hans Bagge, Byggnadsfysik LTH Introduktion För att kunna minska utsläpp av växthusgaser och rädda klimatet på jorden är det av yttersta vikt att vi kan bygga byggnader med låg energianvändning och bra inneklimat. Byggnader står i dagsläget för mellan 30 och 40 %Reducing CO2 emissions is one of the most important goals in Europe as well as the rest of the world. To reach that goal, the use of energy must be reduced. Thus, the building industry is facing a great challenge. Not only energy efficiency but also sustainability is desirable in the building stock. This thesis presents and suggests methods that can be used to improve prediction and verification o
Background: Obstructed labour is still a major cause of maternal morbidity and mortality and of adverse outcome for newborns in low-income countries. The aim of this study was to investigate the role of individual and health facility factors and the risk for obstructed labour and its adverse outcomes in south-western Uganda. Methods: A review was performed on 12,463 obstetric records for the year
Fältsäljare har alltid kännetecknats av att ha ett mobilt arbetssätt där kundkontakt tillhör vardagen och god planering är vitalt. HILTI är ett verktygstillverkande företag som nyligen infört ett mobilt IS-stöd i förhoppning om att underlätta med bland annat planering för fältsäljarna. En explorativ undersökning av företaget har genomförts för att få en uppfattning, utifrån fältsäljarens perspekti
This thesis examines the relationship between international law protecting refugees and national legislation in Sweden and in the UK. International protection is afforded by the 1951 Geneva Convention Relating to the Status of Refugees. But also general international human rights instruments are relevant. These include the Universal Declaration of Human Rights, the International Covenant on Civil
Mass school closures and restricted mobility during the Covid-19 pandemic have intensified matters of technology, teaching, and participation in schools. In response to this situation, this paper examines how attendance practices work during school closure and screen-saturated pandemic isolation at a Swedish upper secondary school. The aim is to empirically and theoretically explore school closure
We present the CH4 and N2O budgets for anthropogenic and natural sources and sinks of Australasia (Australia and New Zealand) from 2010 to 2019 using bottom-up and top-down methods, in line with the RECCAP-2 initiative, with extensions to 2022. We show that the bottom-up CH4 budget for Australasia (2010–2019) was a net source of 14.1 ± 5.5 Tg CH4 yr−1, with Australia and New Zealand contributing 8
Education for sustainability is widely recognised as a critical pathway for driving the transformations needed to address today’s polycrisis. Despite growing theoretical and conceptual advancements in sustainability education, current approaches have not achieved the deep systemic changes required. While university networks and individual institutions increasingly integrate sustainability into the
Understanding catchment behaviour through rainfall-runoff models allows decision makers for proper planning and operation in context of flood risk management. However accurate rainfall-runoff and flood modelling at high spatio-temporal resolutions still remains a significant challenge in any hydrologic and hydraulic studies. This study seeks to develop Hydrologic Engineering Centre’s Hydrologic Mo
Radionuklidterapi är en form av strålbehandling där sjukdom behandlas genom att ett radioaktivt ämne tillförs till kroppen. Typiskt sett består det tillförda ämnet av två sammankopplade komponenter: Dels en radionuklid (radioaktiv variant av ett viss grundämne) och dels ett läkemedel vars egenskaper gör att det tas upp i det sjuka området. Ofta tillförs det radioaktiva läkemedlet via injektion i eRadionuclide therapy (RNT) is a form of radiotherapy that uses unsealed radioactive sources for the delivery of ionising radiation within a patient's body.Radiation dosimetry is not used routinely in all centres, and the RNT field can benefit from more data on pharmacokinetics and absorbed doses (ADs).Consequently, there is a value in developing and investigating methods that facilitates the acqui
Climate change is an increasing threat to sustainable development worldwide. However, the dominant incremental policy approaches have not generated action at anywhere near the rate, scale or depth that is needed. This is largely due to the fact that climate change has historically been framed as a purely external, technical challenge. There is an urgent need for a more integral understanding that
Why should moral philosophers, moral psychologists, and machine ethicists care about computational complexity? Debates on whether artificial intelligence (AI) can or should be used to solve problems in ethical domains have mainly been driven by what AI can or cannot do in terms of human capacities. In this paper, we tackle the problem from the other end by exploring what kind of moral machines are
