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Do quantum mechanical energies calculated for small models of protein-active sites converge?

Simulation of CO2 and Attribution Analysis at Six European Peatland Sites Using the ECOSSE Model

Comparison of Methods to Obtain Force-Field Parameters for Metal Sites

Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin EP4-R essential for agonist-induced beta-arrestin1 recruitment that differs from the apparent principal phosphorylation site.

hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl

Prospects for a regional assessment of forest soil chemistry dynamics in Croatia: Application of the SAFE model to a forested site in the region of Mt. Medvednica

Localization of functional sites in the viral complement inhibitor KCP

Kaposi's sarcoma-associated herpes virus (KSHV) encodes a complement inhibitor named KSHV complement control protein (KCP). We have previously shown that KCP inhibits the human complement system by disrupting the C3 convertase of complement. KCP can accelerate the decay of the classical C3 convertase and it can act as a cofactor for factor I (R), which then cleaves and inactivates C4b or C3b (in t

Developing A Proactive Safety Performance Measurement Tool (SPMT) For Construction Sites

Tracking taphonomy. Analysis of skeletal remains from wild boar (Sus scrofa) and red deer (Cervus elaphus) from Mesolithic sites in Scania, Southern Sweden

Carbon storage in the organic layers of boreal forest soils under various moisture conditions: A model study for Northern Sweden sites

Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice.

Background: Oxidation of LDL is associated with generation of autoantibodies against a large number of different aldehyde-modified peptide sequences in apo B-100. Autoantibodies recognizing peptide sequences in the LDL receptor-binding region of apo B-100 could potentially affect both cholesterol metabolism and atherosclerosis. The aim of the present study was to determine physiological effects of

Human encroachment, climate change and the loss of our archaeological organic cultural heritage : Accelerated bone deterioration at Ageröd, a revisited Scandinavian Mesolithic key-site in despair

Coupled water transport and heat flux in seasonally frozen soils : uncertainties identification in multi-site calibration

Incorporation of Multinuclear Copper Active Sites into Nitrogen-Doped Graphene for Electrochemical Oxygen Reduction

Site-selective ¹³C labeling of histidine and tryptophan using ribose

Seasonal dynamics of haemosporidian (Apicomplexa, Haemosporida) parasites in house sparrows Passer domesticus at four European sites : comparison between lineages and the importance of screening methods

Infectious diseases often vary seasonally in a predictable manner, and seasonality may be responsible for geographical differences in prevalence. In temperate regions, vector-borne parasites such as malaria are expected to evolve lower virulence and a time-varying strategy to invest more in transmission when vectors are available. A previous model of seasonal variation of avian malaria described a

Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides

The β-glucosidase TnBgl1A catalyses hydrolysis of O-linked terminal β-glycosidic bonds at the nonreducing end of glycosides/oligosaccharides. Enzymes with this specificity have potential in lignocellulose conversion (degrading cellobiose to glucose) and conversion of bioactive flavonoids (modification of glycosylation results in modulation of bioavailability). Previous work has shown TnBgl1A to hy

Site-selective ¹³C labeling of proteins using erythrose

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Ischemia-induced upregulation of excitatory amino acid transport sites

Shortcomings in current practices for decision-making process and contaminated sites remediation