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Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
The airflow field around air-intake related geometries has been investigated experimentally and numerically. The configuration of the experimental set-up is used to model a jet engine running near the ground. The experiments have been carried out using both PIV and LDA techniques in order to obtain the mean and fluctuating velocity field as well as the low speed frequencies related to the system o
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
The comparative and combined effects of nitric oxide (NO) and higher alkanes on methane oxidation were examined by experimentation and kinetic modeling. Experiments were conducted using fuel-lean, lower-alkanes mixtures with NO (0-400 ppm v/v) in an atmospheric flow reactor at residence time of 2 s over the temperature range of 820-950 K. NO was found to greatly promote methane conversion, and its
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
We have conducted a phenomenological study on students who will become officers (KB-elever) and our subject is leadership. Our first purpose was to determine their point of view in leadership and how the describe it on two occasions. One occasion before and one after a field-training course in survival techniques. We also wanted to see if the view on leadership was shared and if it had changed aft
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Microsoft Word - Thesis of Ruth Oettle The Environment for sale? The examination of the critical features of a third‐party in facilitating a transaction in the market for environmental offsets. Ruth Oettle ruth.oettle@gmail.com 25 May 2008 Submitted in partial fulfilment of the requirements for the International Master’s Programme in Environmental Studies and Sustainability Science (LUMES), Lund U
https://www.lumes.lu.se/sites/lumes.lu.se/files/oettle_ruth.pdf - 2026-07-25
ORIGINAL PAPER Achieving Standardized Medication Data in Clinical Research Studies: Two Approaches and Applications for Implementing RxNorm Rachel L. Richesson & Susan B. Smith & Jamie Malloy & Jeffrey P. Krischer Received: 16 December 2008 /Accepted: 15 March 2009 /Published online: 3 April 2009 # Springer Science + Business Media, LLC 2009 Abstract The National Institutes of Health has proposed
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_07_richesson_jms_2010.pdf - 2026-07-25
A course offered by the National ATMP Research School - 3 credits (HEC) The course offered by Karolinska Institutet will provide a comprehensive understanding of all steps in process, development and production of cell and gene therapy products. During the course students will gain insight into establishing standard operating procedures (SOPs) for the production of cell and gene therapy products,
Gas chromatographic analyses coupled with electro‐antennographic detection indicated that (Z,E)‐9,11‐tetradecadienyl acetate (Z,E‐9,11–14Ac) is a pheromone component of the cone pyralid Dioryctria abietella. Gas chromatographic − mass spectrometric analyses confirmed the presence of a tetradecadienyl acetate with mass spectrum and retention index identical to Z,E‐9,11–14Ac. A receptor cell sensiti
