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Your search for "2024" yielded 23530 hits

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MASTER (MAnaging Speeds of Traffic on European Roads) aims to provide recommendations for speed management strategies and policies and to elaborate guidelines for the development of innovative speed management tools. Within the framework of the project, field trials with a car equipped with a speed limiter were carried out in three “regional typical” European countries: Sweden, the Netherlands, an

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Frånvaron av ett omedelbart kostnadsansvar i förvaltningsprocessen innebär att enskilda i dagsläget är hänvisade till ett separat skadeståndsförfarande för att få sina rättegångskostnader i förvaltningsmål ersatta. Förvaltningsprocess-lagens [1971:291] (FPL) avsaknad av direkta ersättningsbestämmelser likt de som gäller i civila tvistemål har en rad förklaringar till sig. Förstone handlar det om hThe absence of an immediate cost liability in administrative proceedings means that individuals are currently referred to a separate tort proceeding to be compensated for their litigation costs in administrative cases. The lack of direct compensation provisions in the Administrative Court Procedure Act [1971:291] (FPL) has several explanations. Firstly, it concerns how the com-mon foundations of t

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Max Bengtsson A Site Selection of An Energy Island in the North Sea: Optimal Location in an Ecological and an Economic Scenario Using a Multicriteria Decision Analysis (MCDA). The Danish Government has decided to build an energy island, either as an artificial island in sand, concrete and steel or as a platform solution in the Danish exclusive economic zone (EEZ) of the North Sea. The idea of the

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Objective: Our report describes clinical, genetic, and biochemical features of participants with a molecularly confirmed congenital disorder of glycosylation (CDG) enrolled in the Frontiers in Congenital Disorders of Glycosylation (FCDGC) Natural History cohort at year 5 of the study. Methods: We enrolled individuals with a known or suspected CDG into the FCDGC Natural History Study, a multicenter

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IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a

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Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard

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Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli

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Importance: Studies have suggested an increased risk of psychiatric disorders and suicidal behavior among individuals who have undergone tonsillectomy. However, little is known about stress-related disorders. Objective: To investigate whether surgical removal of tonsils or adenoids is associated with a subsequent risk of stress-related disorders. Design, Setting, and Participants: This cohort stud

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A fundamental aspect of the human mind is its ability to perceive, understand, and remember life experiences, which we process as distinct and meaningful sequences of events, each with a clear beginning and end. This includes experiences from audiovisual media. However, while movies do not explicitly signal when one event ends and another begins, viewers still consistently and automatically percei

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Importance: The 2023 American College of Rheumatology and American Association of Hip and Knee Surgeons Clinical Practice Guideline concluded that obesity alone should not delay joint replacement. Therefore, a substantially increased utilization of joint replacement among patients with obesity could be expected. However, patients with obesity are at increased risk of revision, posing unique challe

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Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte

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Background: Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to re

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CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer's disease and have been studied in relation to several neuropathological features both in patients and in cognitively unimpaired individuals. The CSF p-tau/Aβ42 ratio, a biomarker combining information from both pathophysiological processes, has emerged as a promising tool for moni

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Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,

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Most of the key membrane materials used in industry today were developed in the 1960s and 1970s. The dominant materials on the market include polysulfone, polyethersulfone, polyvinylidene fluoride (PVDF), and polyamide. These materials continue to be the backbone of membrane technologies, owing to their well-established performance, durability, and cost-effectiveness. However, despite significant

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BACKGROUND: Sexual violence against older adults in humanitarian settings is poorly documented, leading to gaps in prevention and delivery of support services. This study aimed to document differences in assault characteristics between younger and older adults, by sex and displacement and disability status and region. METHODS: This retrospective, descriptive observational, multi-country study incl

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Importance: Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective: To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants: Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample

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Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD

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BACKGROUND: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. METHOD: We included participa