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BACKGROUND: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. METHOD: We included participa
IMPORTANCE: Robot-assisted surgery (RAS) is increasingly used for abdominal procedures; however, postoperative pulmonary complications (PPCs) are more frequent in patients undergoing RAS compared with patients undergoing conventional laparoscopic surgery (CLS).OBJECTIVE: To compare the incidence of PPCs after CLS and RAS and to determine which patient-, surgery-, and anesthesia-related factors are
Background: Recent advances have highlighted the potential of artificial intelligence (AI) systems to assist clinicians with administrative and clinical tasks, but concerns regarding biases, lack of regulation, and potential technical issues pose significant challenges. The lack of a clear definition of AI, combined with limited focus on qualitative research exploring clinicians' perspectives, has
Background Prostate-specific membrane antigen (PSMA)-PET usage in patients with prostate cancer is growing rapidly. Thus, novel risk-group definitions based on PSMA-PET are urgently needed for guidelines, clinical use, and trial study design. We report improved risk classification based on PSMA-PET Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE; PPP) nomograms (PPP3) to prognos
Totalbudget för Lunds universitet 2023 Postadress Box 117, 221 00 Lund Telefon, 046-222 8620 E-post filip.bengtsson@eken.lu.se Webbadress www.lu.se Universitetsstyrelsen Totalbudget för Lunds universitet 2023 • Budgeterat resultat för 2023 visar ett underskott på 100 mnkr fördelat på ett underskott på 10,1 mnkr inom utbildning och ett underskott på 89,9 mnkr inom forskning. • Intäkterna förväntas
https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2023-10/fullstandigt_beslut_totalbudget_2023.pdf - 2026-08-17
IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a
Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli
Importance: Studies have suggested an increased risk of psychiatric disorders and suicidal behavior among individuals who have undergone tonsillectomy. However, little is known about stress-related disorders. Objective: To investigate whether surgical removal of tonsils or adenoids is associated with a subsequent risk of stress-related disorders. Design, Setting, and Participants: This cohort stud
MASTER (MAnaging Speeds of Traffic on European Roads) aims to provide recommendations for speed management strategies and policies and to elaborate guidelines for the development of innovative speed management tools. Within the framework of the project, field trials with a car equipped with a speed limiter were carried out in three “regional typical” European countries: Sweden, the Netherlands, an
According to TCO (The Swedish Confederation for Professional Employees) the worst threat to the Swedish welfare is that so many people because of bad health and unemployment are not a part of the labour force. If Sweden could make the number of people with health and unemployment problems half the size as today, the GDP would increase with more than five percent. In real money this means 110 billi
CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer's disease and have been studied in relation to several neuropathological features both in patients and in cognitively unimpaired individuals. The CSF p-tau/Aβ42 ratio, a biomarker combining information from both pathophysiological processes, has emerged as a promising tool for moni
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,
Most of the key membrane materials used in industry today were developed in the 1960s and 1970s. The dominant materials on the market include polysulfone, polyethersulfone, polyvinylidene fluoride (PVDF), and polyamide. These materials continue to be the backbone of membrane technologies, owing to their well-established performance, durability, and cost-effectiveness. However, despite significant
2641Background: BI-1808 is an IgG1 mAb that target TNFR2 by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8+ T cells. Upon co-administration of murine surrogate antibodies targeting TNFR2 and anti-PD-1 to immunocompetent tumor-bearing mice with partial sensitivity to checkpoint blockade, complete cures were observ
As media consumption becomes increasingly individualized, people’s desire for shared cultural experiences remains. Reaction media provides one way to fulfil that need, fostering transnational community (Swan 2018) and a sense of co-presence and immediacy. In their most basic form, reaction media show people filming themselves or being filmed while reacting – viewing, eating, playing, trying out or
Max Bengtsson A Site Selection of An Energy Island in the North Sea: Optimal Location in an Ecological and an Economic Scenario Using a Multicriteria Decision Analysis (MCDA). The Danish Government has decided to build an energy island, either as an artificial island in sand, concrete and steel or as a platform solution in the Danish exclusive economic zone (EEZ) of the North Sea. The idea of the
Rapport till UMAS ledning tisdag 14/11 2006 kl 13 TEDDY årsrapport 1 2013-08-19 TEDDY studien (The Environmental Determinants of Diabetes in the Young) Årsrapport 2012 TEDDY årsrapport 2 2013-08-19 Bakgrund Tillgång till insulin till kroppens celler är en förutsättning för att vi ska kunna leva. Hormonet insulin frisätts från insulinproducerande celler i de Langerhanska öarna i bukspottskörteln. I
https://www.teddy.lu.se/sites/teddy.lu.se/files/2012_teddy_arsrapport.pdf - 2026-08-17
A fundamental aspect of the human mind is its ability to perceive, understand, and remember life experiences, which we process as distinct and meaningful sequences of events, each with a clear beginning and end. This includes experiences from audiovisual media. However, while movies do not explicitly signal when one event ends and another begins, viewers still consistently and automatically percei
Importance: The 2023 American College of Rheumatology and American Association of Hip and Knee Surgeons Clinical Practice Guideline concluded that obesity alone should not delay joint replacement. Therefore, a substantially increased utilization of joint replacement among patients with obesity could be expected. However, patients with obesity are at increased risk of revision, posing unique challe
