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Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 c
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving
Introduction Despite an increasing amount of research related to gender-affirming treatment (GAT) outcomes among transgender and gender-diverse (TGD) people (ie, people who experience discomfort or distress in the misalignment between their gender and sex assigned at birth) in recent years, the evidence base for current recommendations is suboptimal. One contributing factor is the heterogeneity in
Background: The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. Methods: We explored the distribution of PRS313 across European populations using genotype data from 94,072 females without breast cancer
Road traffic pollution is one of the most important factors among other environmental factors that influence the roadside vegetation. The present research examines the impact of motorway flyovers and at-grade roads on air pollution (PM10, SOx, NOx, and air quality index (AQI)) and roadside vegetation in Dehradun by considering the important biochemical parameters such as chlorophyll, ascorbic acid
PURPOSE: To examine sex differences in health-related quality of life (HRQoL) among patients surgically treated for renal cell carcinoma (RCC) in Sweden, utilizing data from the National Swedish Kidney Cancer Register (NSKCR).METHODS: In this study of 4658 surgically treated RCC patients, data on HRQoL, clinical, demographic, and socioeconomic characteristics were retrieved from the NSKCR for pati
Atmospheric inverse modelling and ecosystem data assimilation are two complementary approaches to estimate CH4 emissions. The inverse approach infers emission estimates from observed atmospheric CH4 mixing ratio, which provide robust large scale constraints on total methane emissions, but with poor spatial and process resolution. On the other hand, in the ecosystem data assimilation approach, the
Mild traumatic brain injury (mTBI) is a frequent but underreported consequence of professional cycling crashes, yet current helmet testing standards primarily simulate head-first impacts, and their representation of real-world head impact scenarios is unclear. This study explores crash typology of professional cycling crashes involving head-ground contact through systematic video analysis of 128 h
This thesis analyses the structural limitations of the prevailing entitlement-based framework of international human rights law (IHRL), particularly in pluralistic and multicultural societies, and evaluates whether integrating duties alongside existing rights, a duty-infused reconceptualization, can address those limitations or not? The study draws its primary motivation from a structural crisis i
Industrial pasteurisation is a heat-intensive process with significant potential for decarbonisation. This study investigates how open-source Modelica libraries can be adapted for industry, especially for food industry, and integrated to replace fossil-based thermal systems. Investigations are done to evaluate models of heat pumps, thermal energy storage, specifically the stratified tank, and sol
This thesis examines whether the transfer of a company containing accumulated retained earnings to a shareholder benefiting from a more favourable dividend tax regime can constitute a form of structural dividend stripping under EU law. Unlike traditional dividend stripping arrangements, such as cum-ex and cum-cum transactions, these structures rely on intra-group corporate restructurings through w
Abstract Title: Responsibility Laundering: FIFA and the Discursive Maintenance of Legitimacy Course: Managing People, Knowledge and Change Authors: Aimar Soto and Jesper Laan Supervisor: John Murray Purpose: The purpose of this thesis is to investigate how global organisations maintain legitimacy when operating across multiple and conflicting normative environments. The study’s goal is to understa
This thesis examines whether the institutional monetary policy regime influences corporate risk-taking by comparing publicly listed firms operating under the European Central Bank (ECB) with firms in European countries that retain monetary sovereignty. While previous literature has established that monetary policy affects corporate investment and risk-taking through changes in financing conditions
BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock
BACKGROUND:Detection of ischemia and intracranial hemorrhage (ICH) directly after endovascular thrombectomy (EVT) could enable earlier diagnosis and treatment. We evaluated whether post-EVT Sine Spin cone-beam computed tomography (CBCT) on the Siemens ARTIS Icono biplane system at the end of the procedure can predict ischemia and ICH on subsequent follow-up computed tomography (FUCT) within 48 hou
Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line
