Filetype
Background: The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real-life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity. Methods: We tested for monogenic obesity (genes: LEPR, POMC, ADCY3, PCSK1, CARTPT, SIM1, MRAP2, LEP, NTRK2, BDNF, KSR2, MAGEL2, SH2B1, MC
Prostate Cancer Diagnosis and Treatment Enhancement through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer. PIONEER brings together 34 private and public stakeholders from 9 countries in one multidisciplinary research consortium with the aim of positively transforming the field of prostate cancer clinical care by answering pressing que
Charged-particle jet yields have been measured in semicentral Pb–Pb collisions at center-of-mass energy per nucleon–nucleon collision sNN=5.02 TeV with the ALICE detector at the LHC. These yields are reported as a function of the jet transverse momentum, and further classified by their angle with respect to the event plane and the event shape, characterized by ellipticity, in an effort to study th
In the last decades, the development of high-throughput molecular assays has revolutionised cancer diagnostics, paving the way for the concept of personalised cancer medicine. This progress has been driven by the introduction of such technologies through biomarker-driven oncology trials. In this review, strengths and limitations of various state-of-the-art sequencing technologies, including gene p
The PHENIX experiment has performed a systematic study of identified charged-hadron (π±, K±, p, p¯) production at midrapidity in p+Al, He3+Au, and Cu+Au collisions at sNN=200GeV and U+U collisions at sNN=193GeV. Identified charged-hadron invariant transverse-momentum (pT) and transverse-mass (mT) spectra are presented and interpreted in terms of radially expanding thermalized systems. The particle
Measurements of the pT-dependent flow vector fluctuations in Pb-Pb collisions at sNN=5.02TeV using azimuthal correlations with the ALICE experiment at the Large Hadron Collider are presented. A four-particle correlation approach [ALICE Collaboration, Phys. Rev. C 107, L051901 (2023)2469-998510.1103/PhysRevC.107.L051901] is used to quantify the effects of flow angle and magnitude fluctuations separ
We report the spectroscopic confirmation and fundamental properties of TOI−757 b, a mini−Neptune on a 17.5−d orbit transiting a bright star (V = 9.7 mag) discovered by the TESS mission. We acquired high−precision radial velocity measurements with the HARPS, ESPRESSO, and PFS spectrographs to confirm the planet detection and determine its mass. We also acquired space−borne transit photometry with t
Fishes from the genus Carasobarbus, widely distributed throughout the river systems of North Africa and West Asia, are commonly referred to as Himris. In the Persian Gulf basin, they are widespread and are also found in fast-flowing rivers or the deeper regions of lakes. In this region, representation of these fishes in scientific collections is scarce, and except for C. luteus, the other species
Introduction: Anxiety disorders are common and debilitating in children and adolescents. Cognitive behavioral therapy (CBT), delivered both in-person and by the internet (ICBT), is efficacious, but access for young individuals is limited and it remains unclear how to structure the care pathway to maximize benefit.Methods: To inform a fully powered randomized controlled trial (RCT), a pilot RCT wil
The efficient allocation of flexible resources, such as grid batteries and wind parks, across multiple energy market auctions, is pivotal for maximizing socio-economic welfare, interpreted here as profits. This study explores various optimization methods, including Linear Programming, Integer Linear Programming, Robust Optimization with Linear Programming, and Robust Optimization with Integer Line
In the last ten years, Sweden has seen a noticeable increase in shootings involving young people, which has led to growing media attention and public concern. This thesis explores how Swedish newspapers frame these shootings and how those frames align with public discourse in an online forum in Sweden. The study examines the connection between media framing of youth-involved shootings and public d
Bangladesh faces recurrent and severe flooding due to its low-lying topography and intense monsoon climate, making it one of the most flood-prone countries in the world. These floods pose significant threats to human life, infrastructure, and economic stability which is projected to intensify under future climate change scenarios. This thesis presents a flood susceptibility assessment using the An
Due to rapid urbanization and industrialization, cities have been seen as one of the main contributors to climate change and its negative impacts in recent decades. Many of the Nordic countries have experienced an increased number of torrential rains and floods in recent years, resulting in both property and environmental damage as well as possible negative effects on the well-being of citizens. E
The current legislative framework regarding criminal record checks in Swedish municipalities can be perceived as lacking and may lead to violations of privacy and exclusions of formerly incarcerated individuals. Criminal record checks can, however, help employers make hiring decisions to ensure safety for elders and children. In light of this dilemma, the aim of this research was to examine the le
Shootings have become the central focus in both the political debate as well as in media coverage. Even though shootings are statistically rare, the symbolic impact they have on public perception is significant. The aim of this thesis is to examine how Swedish media symbolically constructs the public- and parochial realm when shootings occur in them, and what symbolic meanings are attributed to th
This thesis examines the compatibility of the European Union’s countervailing duties on imports of Chinese battery electric vehicles with World Trade Organization law. Particular focus is given to the causation and non-attribution requirements under Article 15.5 of the Agreement on Subsidies and Countervailing Measures, in conjunction with the threat of material injury standard under Article 15.7.
