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PURPOSE: Despite the benefits of estrogen receptor (ER)-targeted endocrine therapies in breast cancer, many tumors develop resistance. MicroRNAs (miRNAs) have been suggested as promising biomarkers and we here evaluated whether a miRNA profile could be identified, sub-grouping ER+ breast cancer patients treated with adjuvant Tamoxifen with regards to probability of recurrence.EXPERIMENTAL DESIGN:

Background: Community-based day centres (CBDCs) for people with mental illness are a common service for both people with an immigrant background and native Swedes. Aim: The aim was to compare CBDC attendees with an immigrant background with attendees who were native Swedes in terms of well-being and perceptions of everyday activities and investigate whether ethnic background could predict these fa

Metastases are the major cause of cancer-related deaths, but the mechanisms of the metastatic process remain poorly understood. In recent years, the involvement of microRNAs (miRNAs) in cancer has become apparent, and the objective of this study was to identify miRNAs associated with breast cancer progression. Global miRNA expression profiling was performed on 47 tumor samples from 14 patients wit

Multidrug resistance (MDR) poses a major obstacle to successful chemotherapeutic treatment of cancer, and often involves multiple genes, which may be regulated post-transcriptionally by microRNAs (miRNAs). The purpose of the present study was therefore to identify any resistance-associated changes in miRNA expression in a sensitive and five increasingly drug-resistant Ehrlich ascites tumor (EAT) c

Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic resemblance to benign inflammatory skin diseases. To address whether microRNA (miRNA) profiling can discriminate CTCL from benign inflammation, we studied miRNA expression levels in 198 patients with CTCL, peripheral T-c

Recently it has become clear that interferon (IFN)-α, a type I interferon produced rapidly in response to infection, not only plays a key role in innate immunity, but also promotes adaptive immune responses by influencing the production or function of other cytokines. During infections IFN-α fosters the production of IL-15, which plays a pivotal role in the development, survival and function of NK

BACKGROUND: MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most microRNA expression profiling studies have been performed in human or rodents and relatively limited k

MicroRNAs (miRNA) are a group of short noncoding RNAs that regulate gene expression at the posttranscriptional level. They are involved in many biological processes, including development, differentiation, apoptosis, and carcinogenesis. Because miRNAs may play a role in the initiation and progression of cancer, they comprise a novel class of promising diagnostic and prognostic molecular markers an

Carcinomas of unknown primary origin constitute 3% to 5% of all newly diagnosed metastatic cancers, with the primary source difficult to classify with current histological methods. Effective cancer treatment depends on early and accurate identification of the tumor; patients with metastases of unknown origin have poor prognosis and short survival. Because miRNA expression is highly tissue specific

Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 (miR-21) is upregulated in several cancer types and has been associated with survival in colon cancer. In the present study we developed a robust in situ hybridization assay using high-affinity Locked Nucleic Acid (LNA) probes that specifically detect

Recently, next-generation sequencing has been introduced as a promising, new platform for assessing the copy number of transcripts, while the existing microarray technology is considered less reliable for absolute, quantitative expression measurements. Nonetheless, so far, results from the two technologies have only been compared based on biological data, leading to the conclusion that, although t

Purpose: Catquest-9SF is a 9-item visual disability questionnaire developed for evaluating patient-reported outcome measures after cataract surgery. The aim of this study was to use Rasch analysis to determine the responsiveness of Catquest-9SF for corneal transplant patients. Methods: Patients who underwent corneal transplantation primarily to improve vision were included. One group (n = 199) com

Gasoline Partially Premixed Combustion (PPC) is a promising alternative combustion concept that can offer both high indicated efficiency and low exhaust emissions in terms of NOx and soot, compared to conventional diesel combustion (CDC). Previous research has shown that PPC can operate with gasoline-like fuels of varying RON numbers. Some of the most promising results come with the use of gasolin

Hanöbukten in SE Sweden (including Blekinge archi-pelago) is an important wintering and staging area for a number of waterbird species. The inshore parts have been covered by counts from the shore during the International Waterbird Counts (IWC) since 1969. In the present study we analyze these counts for the period 1969–2014. When the counts started the total number of wintering waterbirds varied

During 1984–2009, Greylag Geese Anser anser were neck-banded at two lakes six kilometres apart in southwest Scania, southernmost Sweden: 2308 at lake Yddingen and 633 at Klosterviken (part of lake Bör-ringe). Through 2013 we recorded 51 132 and 29 937 re-sightings, respectively. We analyse the distribution patterns within Scania during the post-breeding months July–March. In spite of the short dis

This paper deals with a two-echelon spare parts inventory system with one central warehouse and a number of local warehouses facing Poisson demand. Normally, the local warehouses replenish stock from the central warehouse. However, if a demand cannot be satisfied within a pre-determined time window, an emergency shipment is requested from an outside supplier. Moreover, as in practice, this outside

Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes. Heparan sulfate penetrates the membrane and is transported to the nucleus. This process is dependent on copper and on expression and processing of the amyloid precursor protein. It remains unclear how exogenously supplied ascorbate can generate HS-anMan in endosomes an

The likelihood that females will breed or how much they invest in reproduction can depend on the characters of their male partners. Such differential allocation may enhance or limit gene flow between hybridizing lineages, in particular when the lineages have diverged in sexually selected characters. Populations of the common wall lizard (Podarcis muralis) in some regions of Italy exhibit striking