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The intrinsically disordered MYC proteins are master regulators of cellular growth and function, but when deregulated they become cancer drivers. MYC-protein interactions are key to oncogenesis, and while disrupting such interactions would be of significant therapeutic benefit, the intrinsically disordered properties of MYC have dramatically hampered their characterization. Here, we apply an integ
X-rays are commonly used in imaging experiments due to their penetration power, which enables non-destructive resolution of internal structures in samples that are opaque to visible light. Time-resolved X-ray tomography is the state-of-the-art method for obtaining volumetric 4D (3D + time) information by rotating the sample and acquiring projections from different angular viewpoints over time. Thi
Storm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and someStorm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and some
Short-range correlations between charged particles are studied via two-particle angular correlations in pp collisions at √s = 13 TeV. The correlation functions are measured as a function of the relative azimuthal angle ∆φ and the pseudorapidity separation ∆η for pairs of primary charged particles within the pseudorapidity interval |η| < 0.9 and the transverse-momentum range 1 < pT< 8 GeV/c. Near-s
The Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sigThe Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sig
Almost 200 years after their inception, news beats became a dominant factor that shapes newsrooms. This study explores the beat mix of leading quality dailies in 13 countries. Findings are based on executive interviews triangulated with other data sources. They indicate a shift from geographic to thematic division of labour and the rising trend of beat sub-specialisation. Newsroom size matters but
This Letter presents measurements of long-range transverse-momentum correlations using a new observable, v0(pT), serving as a probe of event-by-event radial-flow fluctuations, the underlying radial expansion, and the medium's properties in heavy-ion collisions. Results are reported for inclusive charged particles, pions, kaons, and protons across various centrality intervals in Pb-Pb collisions at
I Sverige lever idag 100 000 personer med Alzheimers sjukdom, en neurodegenerativ demenssjukdom som främst drabbar äldre personer. I takt med en åldrande befolkning kommer Alzheimers att påverka fler människor. Därför är det viktigt att utreda hur denna sjukdom utvecklas på ett molekylärt plan, för att kunna förebygga sjukdomsutvecklingen och utveckla bättre läkemedel. En bakomliggande orsak tillThe accumulation of amyloid-β42 fibrils is a hallmark in patients with Alzheimer's disease. The small heat-chock protein αB-crystallin is known to co-exist with amyloid-β42 fibrils and prevent amyloid fibril formation. Amyloid-β42 fibrils arise and expand through different mechanisms of nucleation, however the targeted mechanism by αB-crystallin is yet to be determined. The aim of this project
Denna studie undersöker om resursfördelningen till förskolan i Sverige följer ett kompensatoriskt mönster i relation till kommuners socioekonomiska nivå. Med utgångspunkt i humankapitalteori och skollagens mål om likvärdig utbildning analyseras sambandet mellan medianinkomsten i kommuner och kostnad per barn i förskolan. Analysen baseras på paneldata för Sveriges 290 kommuner under perioden 2015–
This study aims to investigate how social media trends affect international trade through a study on the relationship between the global matcha tea trend and Japanese green tea exports. The study is performed in two steps, due to limitations in social media data access. Firstly, a time-series regression is used to analyse the relationship between global TikTok views and Google search intensity for
This thesis examines whether implied volatility derived from Swedish equity options provides superior predictive information relative to historical volatility for future realized volatility and stock returns, and whether this information improves portfolio risk outcomes. Using monthly option and stock data for OMXS30 firms, the study applies predictive regressions and constructs minimum variance p
This study investigates whether municipal corruption has influenced the impact of the Brazilian conditional cash transfer program Bolsa Família by comparing the Human Development Index (HDI) in 2000 and 2010. The decentralized implementation of Bolsa Família is modeled as a principal-agent problem between the federal government and local municipalities, where the federal government has utilized va
Initial public offerings take place under varying market conditions, where periods of high listing activity often coincide with high initial returns and increased uncertainty. At the same time, prior research shows that firms going public tend to underperform the market in the long run. This study examines the extent to which firm-specific fundamentals can explain long-term performance following a
This thesis investigates whether volatility in the U.S. and the European equity markets influences each other and whether sush cross-market effects improve volatility forecasting. Using the S&P 500 and STOXX Europe 600 as representative indices, the study models volatility dynamis with Heterogeneous Autoregressive (HAR) framework and an extended specification that allowa for spillover effects
This thesis examines whether more generous unemployment insurance is associated with greater household portfolio risk-taking in Europe by reducing background income risk. Using a largely balanced panel of European countries, the analysis measures household risk-taking as the share of household financial assets held in equity and investment fund shares. Unemployment insurance generosity is proxied
The thesis investigates how changes in weekly working hours for full time employees influence the structure of employment - and more precisely the distribution between full-time and part-time positions. Although policy discussions on shorter workweeks often center around productivity and the total employment level, less attention has been paid to how such reforms reshape working time arrangements
This thesis examines exchange-rate pass-through (ERPT) to food inflation in Ghana with a focus on domestic transmission channels. Using monthly data, it estimates dynamic reduced-form equations for food inflation and for a set of producer,logistics, transport, and energy-related cost measures. The results show that exchange-rate depreciation passes through meaningfully to food inflation over sever
Background: Fragrance allergens are a leading cause of contact allergy (CA). Linalool, common in cosmetics and household products, forms sensitising hydroperoxides (Lin-OOH) upon air exposure. Lin-OOH is linked to a high prevalence (3.9%–11.7%) of positive patch test results, but often gives rise to doubtful or irritant reactions. Objectives: To reassess patch test concentrations of Lin-OOH, deter
Electrospinning is a versatile technique for manufacturing micro-nano diameter fibers and has been used extensively for tissue engineering in vivo and advanced cell culture in vitro. Standard means of seeding cells onto such substrates typically offer no control over cell distribution, yielding dispersed, heterogeneous and low concentrations of cells. In this article, we investigate the viability
