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Many plant invasions establish from only a few individuals and exhibit clonal spread, providing an opportunity to examine the genomic mechanisms that underlie the success of particularly aggressive individuals. One of the world’s most invasive species, the Japanese knotweed complex, is well suited for such investigations. Simultaneously developing ecological and genomics work in the native and int
Play is a quintessential human behaviour, underpinned by motor organisation and fundamental for learning and development. However, the motor patterns underlying play have not been computationally characterised in children with autism, despite known play pattern differences, including reduced social and pretend play. Recent evidence of fundamental neuromotor disruption in autism suggests neuromotorPlay is a quintessential human behaviour, underpinned by motor organisation and fundamental for learning and development. However, the motor patterns underlying play have not been computationally characterised in children with autism, despite known play pattern differences, including reduced social and pretend play. Recent evidence of fundamental neuromotor disruption in autism suggests neuromotor
Implementing the Internet of Things (IoT) into business models has become an influential catalyst, supporting novel revenue generation, improved operational efficiencies, and competitive dominance. Still, its implementation has been challenged by barriers to technological, organizational, and societal dimensions. The current study utilizes the Fuzzy Decision-Making Trial and Evaluation Laboratory
The in vivo fate of mesenchymal stromal cells (MSCs), including their clearance, interaction with host tissues, and persistence, remains incompletely understood following systemic or local clinical administration to patients. Although immune-mediated clearance mechanisms, such as triggering of the instant blood-mediated inflammatory reaction, activation of coagulation and complement pathways, apop
Background and purpose — Patient-specific instrumentation (PSI) in total knee arthroplasty (TKA) aims to improve implant alignment and clinical outcomes, but its effectiveness remains uncertain. We aimed to compare whether PSI was superior to conventional instrumentation (CVI) in TKA. The primary outcome was the Oxford Knee Score (OKS) at 2 years with assessments of additional clinical outcomes up
Aggressive tumours are defined by microenvironmental stress adaptation and metabolic reprogramming. Within this niche, lipid droplet accumulation has emerged as a key strategy to buffer toxic lipids and suppress ferroptosis. Lipid droplet formation can occur via de novo lipogenesis or extracellular lipid-scavenging. However, how tumour cells coordinate these processes remains poorly understood. He
In the face of climate change, today’s young people need to balance the challenges of being active and maintaining mental health. This study investigated climate resilience, meaning patterns of climate engagement and mental health among adolescents. Using latent profile analysis, we identified three profiles in a sample of N=603 Swedish adolescents: climate-resilient (17%, active and not impaired)
Protein deletions are frequent among both disease-causing and tolerated variants. Several mechanisms at the DNA, RNA and protein levels can lead to deletions. Many deletions are misclassified in the literature and databases, especially when the mRNA is degraded by the cellular quality-control mechanism. We developed a novel predictor for sequence retaining protein deletions, i.e., variants that do
Understanding variation in survival and reproduction is key for conservation and management of bird populations. By compiling and analysing data on hatching success (i.e. proportion of nests with at least one hatched egg) from Common Eider Somateria m. mollissima, Velvet Scoter Melanitta fusca and Red-breasted Merganser Mergus serrator, all breeding on a single island in the Baltic Sea, we demonst
Background: Colorectal cancer (CRC) is a major health concern. In Sweden, a CRC screening program was implemented nationwide between 2019 and 2022. This study evaluated participation, colonoscopy adherence, and diagnostic outcomes for the program's first five years. Methods: The target group of screening was all residents 60–74 years old. Data were retrieved from SveReKKS, the Swedish national qua
The rise in milk adulteration and contamination, fraud incidents and improper handling necessitates effective traceability systems in the Indian dairy industry. Thus, this review investigates current trends, associated challenges, traceability and its fundamental applications to address food safety and quality issues. The paper covers the evolution of milk adulteration and contamination detection
Purpose – This article’s purpose is to examine how the balance between autonomy (stewardship) and control (principal-agent) has evolved over 2 decades through a comparative longitudinal study of university governance reforms in Denmark and Sweden. Design/methodology/approach – Employing a longitudinal comparative case study design, the study draws on extensive document analysis and applies a theor
Forest Canopy Height (FCH) is one of the key variables for understanding forest structure distribution and growth. Remotely sensed data such as the NASA Ice, Cloud and Land Elevation Satellite-2 (ICESat-2) ATL08 provides accurate FCH measurements; however, its point-based nature limits spatial continuity. This study addresses the challenge by generating a continuous FCH map over the West Usambara
Natural selection has produced diverse vision systems, from simple patches of photoreceptors to complex camera eyes, representing just one set of evolutionary outcomes. Computational evolution offers a way to systematically test hypotheses, isolate individual factors, and ask the “why” questions behind vision. We recreate vision evolution by coevolving eyes and behaviors in embodied agents and use
BACKGROUND: The EAT-Lancet planetary health diet emphasises plant-based foods while including moderate amounts of animal-sourced foods. Simulation-based modelling studies suggest that the diet can provide adequate micronutrients, but concerns remain about potential deficiencies as studies have used different methodologies and few have assessed nutrient intakes using both dietary and biomarker data
The function of the brain is defined by the interactions between its neurons. But these neurons exist in tremendous numbers, are continuously active, and densely interconnected. Thereby, they form one of the most complex dynamical systems known and there is a lack of approaches to characterize the functional properties of such biological neuronal networks without resorting to dimensionality reduct
Takotsubo syndrome (TTS) is an acute, reversible form of left ventricular dysfunction, typically triggered by emotional or physical stress. The hallmark feature is reversible regional wall motion abnormality extending beyond a single coronary distribution, most commonly presenting with an apical ballooning pattern. The pathophysiology is multifactorial, encompassing neurohormonal dysregulation, ca
Groundwater in most parts of the world is an important source of agricultural water supply for food production. Soil salinization, however, threatens groundwater quality and may cause irreparable damage to agricultural land. A key to tackling this threat is to analyze the link between agricultural crop water requirements and groundwater quality. This study aimed to investigate salinity effects on
