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To meet future demands for cleaner water and comply with the revised Urban Wastewater Treatment Directive (UWWTD), many European wastewater treatment plants (WWTPs) will need quaternary treatment to reduce emissions of organic micropollutants (OMPs). Quaternary treatment based on granular activated carbon (GAC) is a promising solution, yet long-term, full-scale operational data remain scarce. This

Purpose To investigate patient-reported symptom relief day-by-day and the use of postoperative analgesics after open trigger finger release. The primary outcome of this study was the number of days to resolution of pain. Secondary outcomes were the use of analgesics and the number of days to complete resolution of stiffness and triggering. Methods In this prospective, multicenter cohort study, a t

Weight bias is a social justice issue that manifests in social and health inequities, affecting the lives of millions of individuals globally. Although weight bias research has increased over the last two decades, it remains pervasive, and more work is needed to establish effective strategies to reduce it. The 2024 International Weight Bias Summit aimed to collaboratively identify future research

Triple-negative breast cancer (TNBC) exhibits heterogeneous treatment responses, yet molecular subtypes based on predefined biological pathways show limited prognostic value. We introduce tumor-specific total mRNA expression (TmS), a pathway-agnostic deconvolution metric derived from matched RNA/DNA sequencing, as a robust stratification tool. Analyzing 575 TNBC patients across Western and East As

Artikeln analyserar hur svenska myndigheter anpassade sin samhällsinformation till den kommersiella tv-reklamens logik i början av 1990-talet. Med Försäkringskassans omdebatterade kampanj med Ronny och Ragge inför Socialförsäkringens dag 1993 som fallstudie undersöks hur gränserna mellan kunskap, information och underhållning förhandlades i ett avreglerat medielandskap. Studien visar hur en tidiga

Group A Streptococcus (GAS) forms highly deformable aggregates with broad variations in size and morphology, complicating controlled separation and biological analysis. Reliable methods to isolate fractions of GAS clusters with defined properties are essential for studying host–pathogen interactions that depend on cluster size. Here, we present a simple deterministic lateral displacement (DLD) mic

The purpose of this pilot study was to develop and characterize an in vivo porcine model of hyperoxaluria using intravenous infusion of sodium oxalate (NaOx). Two experimental regimens were developed to replicate acute and follow up chronic hyperoxaluria. In the acute model, 3 different doses of 1% NaOx were administered over 15 h, resulting in a dose-dependent increase in plasma oxalate concentra

Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). To improve treatment guidance, biomarkers are needed. We use whole-genomics (WGS; n = 155) with matching whole-transcriptomics (WTS; n = 113) from biopsies of ARSI-treated mCRPC patients for unbiased discovery of biomarkers and development of machine learning-based pr

PURPOSE: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using large cohorts. Thus, we sought to identify the intrinsic molecular subtypes of mCRPC and assess molecular and clinical correlates in the largest combined cohort

Background and purpose —The use of a tourniquet in knee replacement surgery is debated. Given the conflicting evidence, we aimed to compare the risk of revision after total knee replacements (TKR) with or without the use of tourniquet. Methods — In this register based observational study, we included the 5 most common cemented primary TKR models due to osteoarthritis reported to the Swedish Arthro

We report the inverse association between the expression of androgen receptor (AR) and interleukin-1beta (IL-1β) in a cohort of patients with metastatic castration resistant prostate cancer (mCRPC). We also discovered that AR represses the IL-1β gene by binding an androgen response element (ARE) half-site located within the promoter, which explains the IL-1β expression in AR-negative (ARNEG) cance

Meningsinterna skiljetecken – här kolon, tankstreck och parentes – används vanligtvis inte för att dela en sats i mindre delar, utan för att avgränsa satsexterna element från själva satsen. Den här studien utgår från dessa tre skiljetecken för att identifiera och kategorisera sådana element och de meningar de förekommer i, här kallade tilläggsstrukturer. Tilläggsstrukturer består av en initial ellSentence-internal punctuation marks – here the colon, dash and parenthesis – are not typically used to split a clause into smaller parts, but rather to delimit clause-external elements from the clause proper. This study uses these three punctuation marks as a starting point to identify and categorize such elements and the sentences containing them, here called supplement structures. Supplement str

We develop a Lyapunov-based analysis of Korpelevich’s extragradient method and show that it achieves an o(1/k) last-iterate convergence rate of the constructed Lyapunov function. This Lyapunov function simultaneously upper bounds several standard measures of optimality, which allows our analysis to sharpen existing last-iterate convergence guarantees for these measures. Moreover, the same analysis

Introduction: The importance of measuring vascular age has been emphasized in numerous studies, highlighting its critical role in precision medicine. This cross-sectional heterogeneity exploration study examined sex- and country-specific association of serum uric acid (SUA) and inflammation, measured as high sensitivity C-reactive protein (hs-CRP), and vascular aging across populations with divers

Background Aortic valve calcification (AVC) is a disease process driven by inflammation and lipid infiltration, serving as a precursor to aortic stenosis. While male sex has been implicated as a risk factor for AVC, sex-specific differences, particularly among younger individuals in the general population, are not well characterised. Methods The Swedish CArdioPulmonary BioImage Study was used, com

The downscaling of environmental responsibilities poses new challenges for regional governments, necessitating an evolution in their roles to manage environmental policy alongside traditional local development duties. This paper draws on the concept of the entrepreneurial state and on the idea of the ‘entrepreneurial region’ to explore how local and regional governments implement bioeconomy polici