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A new indole alkaloid, picranitine, has been-isolated from the seeds of Picralima nitida, along with five known, indole alkaloids picratidine, akuammine, pseudoakuammine, akuammicine and akuammidine previously identified from the same source. Structures were elucidated through exhaustive spectral studies including 1D. (H-1 and C-13 NMR) and 2D-NMR (HMQC, HMBC and NOESY).
Titanium oxide and zirconium oxide thin films deposited on silicon substrates were characterised using electron probe microanalysis (EPMA), Rutherford backscattering spectroscopy (RBS), time-of-flight elastic recoil detection analysis (TOF-ERDA) and scanning photoelectron microscopy (SPEM). The composition and mass thickness of the films were determined and the results of different methods compare
Background: The diagnostic criteria of the metabolic syndrome ( MS) have been applied in studies of obese adults to estimate the metabolic risk-associated with obesity, even though no general consensus exists concerning its definition and clinical value. We reviewed the current literature on the MS, focusing on those studies that used the MS diagnostic criteria to analyze children, and we observed
The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and one case of polycythemia vera. Recently, the t(11;20) was shown to result in a fusion of the NUP98 and TOP1 genes, with expression of the NUP98/TOP1 chimera encoded by the der(11)t(11;20), but not of th
Proteoglycans contribute to extracellular matrix remodeling in asthmatic airways. We investigated the effects of budesonide, a glucocorticoid, and formoterol, a long-acting beta(2)-adrenergic agonist, on serum-induced proteoglycan production by human lung fibroblasts. In 10% serum, total proteoglycan production was increased 1.5-fold (P < 0.01) compared with basal production in 0.4% serum. Budeson
Saarinen recently proposed a chosen IV statistical attack, called the $d$-monomial test, and used it to find eaknesses in several proposed stream ciphers. In this paper we generalize this idea and propose a framework for chosen IV statistical attacks using a polynomial description. We propose a few new statistical attacks, apply them on some existing stream cipher proposals, and give some conclusi
Proteoglycan aggregates were extracted from Swarm rat chondrosarcoma tissue in the native state and compared with proteoglycan aggregates isolated dissociatively with 4 M guanidine HCl. Purified aggregates were examined with a variety of electron microscopic techniques. In some cases they showed a structure of the central filament identical to that of the link-stabilized central filament observed
The origin dependence of the expression of two-photon circular dichroism in the length formulation employed by the authors in a recent computational study [B. Jansik , Chem. Phys. Lett. 414, 461 (2005)] is discussed in detail, and some inherently origin invariant alternative formulations are introduced. Extensive computational tests on a small reference chiral system, namely, a chiral form of H2O2
During δ-aminolevulinic acid (ALA) based Interstitial Photodynamic Therapy (IPDT) a high light fluence rate is present close to the source fibers. This might induce an unintentional tissue temperature increase of importance for the treatment outcome. In a previous study, we have observed, that the absorption in the tissue increases during the treatment. A system to measure the local tissue tempera
Sediment successions from the Kanin Peninsula and Chyoshskaya Bay in northwestern Russia contain information on the marginal behaviour of all major ice sheets centred in Scandinavia, the Barents Sea and the Kara Sea during the Eemian - Weichselian. Extensive luminescence dating of regional lithostratigraphical units, supported by biostratigraphical evidence, identifies four major ice advances at 1
Human tissue kallikreins (hKs) are a family of fifteen serine proteases. Several lines of evidence suggest that hKs participate in proteolytic cascade pathways. Human kallikrein 5 (hK5) has trypsin-like activity, is able to self-activate, and is co-expressed in various tissues with other hKs. In this study, we examined the ability of hK5 to activate other hKs. By using synthetic heptapeptides that
Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthm
It is likely that everyone will, at some time, suffer from a problem related to the musculoskeletal system, ranging from a very common problem such as osteoarthritis or back pain to severely disabling limb trauma or rheumatoid arthritis. Many musculoskeletal problems are chronic conditions. The most common symptoms are pain and disability, with an impact not only on individuals’ quality of life bu
An updated version of the spectral ( bin) microphysics cloud model developed at the Hebrew University of Jerusalem [ the Hebrew University Cloud Model (HUCM)] is described. The model microphysics is based on the solution of the equation system for size distribution functions of cloud hydrometeors of seven types ( water drops, plate-, columnar-, and branch-like ice crystals, aggregates, graupel, an
The value of primary chemical compounds correlated with known secondary chemistry and morphological variation within the Ramalina siliquosa group has been investigated. A hundred specimens were collected on two different occasions from 13 different populations on the Swedish west coast during April 1984. Protein extracts were prepared from 27 on secondary constituents identified and morphologicall
The activity of ADAMTS 13, the von Willebrand factor cleaving protease, is deficient in patients with thrombotic thrombocytopenic purpura (TTP). In the present study, the phenotype of ADAMTS13 in TTP and in normal plasma was demonstrated by immunoblotting. Normal plasma (n=20) revealed a single band at 190 kD under reducing conditions using a polyclonal antibody, and a single band at 150 kD under
Incubator covers are increasingly being used in neonatal care as part of minimal disturbance strategies. The aim of this study was to examine possible effects of incubator covers on sleep patterns in stable premature infants. Quiet sleep (QS) can be investigated by amplitude-integrated electroencephalography (aEEG) at 32–34 weeks gestational age. In nine premature infants (gestational ages 26–32 w
The presence and diversity of IncP-1 plasmids in the influent of a Danish wastewater treatment plant was studied by PCR amplification of the trfA gene in community DNA followed by sequencing. Three sets of PCR primers were designed to amplify a 281 bp fragment of trfA from all currently sequenced IncP-1 plasmids. A neighbor-joining tree, based on a multiple alignment of 72 obtained sequences toget
