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The phosphatidylinositol 3-kinase/AKT pathway is an integral component of signaling involved in the development of many cancers, including myeloid leukemias such as chronic myeloid leukemia and acute myeloid leukemia (AML). Increased AKT1 activity is frequently seen in AML patients, providing leukemic cells with growth and survival promoting signals. An important aspect of AKT1 function is its inv

Present work aims at evaluation of contemporary comprehensive detailed kinetic mechanisms for ethylene combustion, including the Konnov mechanism, LLNL nButane mechanism, San Diego (UCSD) mechanism and USC mechanism. These models have been validated by extensive comparison with available experimental data on ethylene ignition and flame propagation. The experimental data from the literature have be

To analyse the hypothesis that a gradual deregulation of traveller allowances, starting in 2001 and ending in 2004, on alcoholic beverages changed consumer behaviours that ultimately led to an increase in alcohol consumption in southern Sweden between in 2005 compared with 1999.

OBJECTIVES: To evaluate the outcome of treatment for deep sternal wound infection (DSWI) in a nationwide patient cohort, before and after the introduction of negative-pressure wound therapy (NPWT). METHODS: This was a population-based cohort of all patients treated for DSWI in Iceland out of 2446 open heart operations performed between 2000 and 2010. Length of hospital stay, survival and reoperati

Background: The focus on Alzheimer's disease (AD) is shifting from dementia to the prodromal stage of the disorder, to a large extent due to increasing efforts in trying to develop disease modifying treatment for the disorder. For development of disease-modifying drugs, a reliable and accurate test for identification of mild cognitive impairment (MCI) due to AD is essential. Objective: In the pres

Few previous studies of metabolic aberrations and prostate cancer risk have taken into account the fact that men with metabolic aberrations have an increased risk of death from causes other than prostate cancer. The aim of this study was to calculate, in a real-life scenario, the risk of prostate cancer diagnosis, prostate cancer death, and death from other causes.

Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into C

AimsImmunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic power of antibodies used frequently for clinical differential diagnostics. Method

We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 nonsmokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contribut

Avian ecosystem services such as the suppression of pests are considered to be of high ecological and economic importance in a range of ecosystems, especially in tropical agroforestry. However, how bird predation success is related to the diversity and composition of the bird community, as well as local and landscape factors, is poorly understood. We quantified arthropod predation in relation to t

Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and d

This paper describes experiments to extract discourse relations holding between two text spans in Swedish. We considered three relation types: cause-explanation-evidence (CEV), contrast, and elaboration and we extracted word pairs eliciting these relations. We determined a list of Swedish cue phrases marking explicitly the relations and we learned the word pairs automatically from a corpus of 60 m

The existence and effect of different rare earth (R2+/3+/IV) ions in SrAl2O4:Eu2+, R3+ and M2MgSi2O7:Eu2+, R3+ (M: Sr, Ba) persistent luminescence materials was studied with XANES (x-ray absorption near edge structure) measurements at HASYLAB/DESY (Hamburg, Germany) and MAX-lab (Lund, Sweden). The experiments were carried out at 298K for selected rare earth (co-) dopants (Eu2+; Ce3+, Nd3+, Sm3+, D

The emission of W and Z gauge bosons off quarks is included in a traditional QCD + QED shower. The unitarity of the shower algorithm links the real radiation of the weak gauge bosons to the negative weak virtual corrections. The shower evolution process leads to a competition between QCD, QED and weak radiation, and allows for W and Z boson production inside jets. Various effects on LHC physics ar

This paper describes the changing everyday life mobility of an older couple living in a suburb in Sweden. The methods used are longitudinal interviews and time-geographical diaries. The results show a pronounced dependence on car use. Representations of suburbia - as places of freedom, independence and mobility enabled by private cars - devolve into a harsh reality, i.e. disabling lock-in effects

Recent studies have highlighted the involvement of rare (<1% frequency) copy-number variations and point mutations in the genetic etiology of autism spectrum disorder (ASD); these variants particularly affect genes involved in the neuronal synaptic complex. The SHANK gene family consists of three members (SHANK1, SHANK2, and SHANK3), which encode scaffolding proteins required for the proper format

We have measured helium and neon concentrations, elemental and isotopic ratios of 91 individual presolar graphite grains from the KFC1 density separate of the Murchison meteorite. Eleven grains contain measurable amounts of either (4)He, (20)Ne, (21)Ne or (22)Ne, or a combination thereof. We report the first detection of (21)Ne from an individual presolar graphite grain and the first detection of

Group G streptococcus (GGS) is a human bacterial pathogen expressing surface proteins FOG and protein G (PG) which interact with several host defense systems, including the complement and contact systems. Selected reaction monitoring mass spectrometry, electron microscopy, and protein binding assays were used to follow the amounts of FOG and PG intracellularly and on the bacterial surface during d