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Popular Abstract in English Thirty years after the discovery of HIV, the AIDS epidemic is still with us. While the incidence is declining globally and access to anti-retroviral therapy for low- and middle-income countries is improving, the number of new HIV infections is still high. Despite stubborn efforts to design viral immunogens, an effective formulation for the induction of broad and potent Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimu

A determination of the single W spin density matrix (SDM) elements in the reaction e(+)e(-) -> W+W--> l nu q (q) over bar (l=e/mu) is reported at centre-of-mass energies between 189 and 209GeV. The data sample used corresponds to an integrated luminosity of 520pb(-1) taken by DELPHI between 1998 and 2000. The single W SDM elements, rho(W +/-)(tau tau') (tau,tau'=+/- 1 or 0), are determined as a fu

Background: Recently, heterozygous mutations in PRRT2 (Chr 16p11.2) have been identified in Han Chinese, Japanese and Caucasians with paroxysmal kinesigenic dyskinesia. In previous work, a paroxysmal kinesigenic dyskinesia locus was mapped to Chr 16p11.2 - q11.2 in a multiplex African-American family. Methods: Sanger sequencing was used to analyze all four PRRT2 exons for sequence variants in 13 p

Background: Several reproductive and hormonal factors are known to be associated with ovarian cancer risk in the general population, including parity and oral contraceptive (00 use. However, their effect on ovarian cancer risk for BRCA1 and BRCA2 mutation carriers has only been investigated in a small number of studies. Methods: We used data on 2,281. BRCA1. carriers and 1,038 BRCA2 carriers from

Background: Statin medications, used to prevent heart disease by reducing cholesterol, also reduce inflammation and protect against oxidative damage. As inflammation and oxidative stress occur in depression, there is interest in their potential to reduce depression risk. We investigated whether use of statin medications was associated with a change in the risk of developing depression in a very la

We present a new guide-split concept for transporting cold and thermal neutrons to multiple instruments from a single beam port at a neutron facility without compromising the useful neutron brilliance notably for any of the instruments. Elliptical guides are capable of transporting an almost completely filled phase space within a large divergence (+/- 2 degrees for cold neutrons). It is therefore

Columnar metaplasia, where columnar epithelium replaces the normal squamous epithelium in esophagus, is considered to be a precancerous condition in which the development of adenocarcinoma can be followed through various grades of dysplasia. The interpretation of these histological changes is subjective and suffers from considerable inter-observer variation among pathologists. In study I, we devis

We propose a theory-neutral, computational and data-driven method for assessing changes in semantic content of object representations following long-term psychodynamic psychotherapy. Young adults in psychotherapy are compared with an age-matched, non- clinical sample at three time points. Verbatim transcripts of descriptions of the self and parents were quantified in a semantic space constructed b

Abstract—Resource management in IT–enterprises gain more and more attention due to high operation costs. For instance, web sites are subject to very changing traffic–loads over the year, over the day, or even over the minute. Online adaption to the changing environment is one way to reduce losses in the operation. Control systems based on feedback provide methods for such adaption, but is in natur

The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. We have investigated the haematopoietic phenotype of an HSC in a mouse model where hypoxia-regulated Vegfa expression is abrogated.

This study investigates the genetic structure of an eukaryotic microorganism, the toxic dinoflagellate Alexandrium ostenfeldii, from the Baltic Sea, a geologically young and ecologically marginal brackish water estuary which is predicted to support evolution of distinct, genetically impoverished lineages of marine macroorganisms. Analyses of the internal transcribed spacer (ITS) sequences and Ampl

We have studied the effect of different light gradient regimes on host-plant selection of the carrot psyllid, Trioza apicalis Forster. In both a strong and a weak light gradient, carrot psyllids preferred a carrot leaf placed in higher light intensity. When the choice was between the host (carrot Daucus carota L.) and a non-host (barley Hordeum vulgare L.) virgin adults settled significantly more

Background: Physical benefits are suggested for women and their babies when women adopt an upright position of their choice at birth. Available care options during labour influence women's impressions of what intrapartum care is. This indicates that choice of birth positions may be determined more by midwives than by women's preferences. Question: The aims of this study were to investigate factors