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Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18
The formation mechanism and the evolution of optoelectronic properties during annealing of chlorine-derived methylammonium lead iodide (MAPbI3-xClx) are investigated in detail combining in situ and ex situ optical and structural characterization. Using in situ optical reflectometry we are able to monitor the evolution of the MAPbI3-xClx phase as a function of time and processing temperature. The f
Among the fundamental biological processes affected by microRNAs, small regulators of gene expression, a potential role in host-parasite communication is intriguing. We compared the miRNA complement of extracellular vesicles released by the free-living nematode Caenorhabditis elegans in culture to that of other adult parasitic nematodes. Expecting convergent functional roles for secreted miRNAs du
We performed a national population-based study of all patients diagnosed with diffuse large B-cell lymphoma (DLBCL) in Sweden in 2007–2014 to assess treatment intent and risk of relapsed/refractory disease, including central nervous system (CNS) relapse, in the presence of competing risks. Overall, 84% of patients started treatment with curative intent (anthracycline-based) (n = 3550, median age 6
In the present review, we highlight the possible “extra-immunological” effects of maternal immunoglobulins (Ig) transferred to the blood circulation of offspring, either via the placenta before birth or via the colostrum/milk across the gut after birth in different mammalian species. Using the newborn pig as a model, since they are naturally born agammaglobulinemic, intravenously (i.v.) infused pu
In the mixed-valence manganites, a near-infrared laser typically melts the orbital and spin order simultaneously, corresponding to the photoinduced d1d0→d0d1 excitations in the Mott-Hubbard bands of manganese. Here, we use ultrafast methods-both femtosecond resonant X-ray diffraction and optical reflectivity-to demonstrate that the orbital response in the layered manganite Nd1-xSr1+xMnO4(x=2/3) do
In the present study, strategies are developed to enable time-efficient models for structures subjected to blast loading, appropriate for use in a structural design process. Dynamic sub structuring is employed to obtain reduced models with localized nonlinearities, such as predefined plastic hinges in a beam column structure. The parts of the substructures that remains linear elastic are modeled b
Ground vibration associated with pile driving causes annoyance to inhabitants of the neighbouring environment and may possibly lead to damage on existing structures in the proximity of a construction site. Vibration mitigation near the source can reduce the problem. The paper investigates the effect of circular arrays of blocks, placed on the ground surface around the position at which the pile is
The SHE departments devoted to the research of superheavy elements, operate the recoil separators SHIP and TASCA and their ancillary installations including SHIPTRAP and a laser spectroscopy setup at SHIP as well as chemistry and nuclear spectroscopy setups at TASCA. In 2019, the activities at GSI focused on the UNILAC beamtime within the FAIR Phase-0 program and on the analysis of data obtained i
Measurements of the atmospheric concentration of polluting atomic mercury were performed using the differential absorption lidar (DIAL) technique in the Lintong district, about 35 km northeast of Xi’an, the capital of the Shaanxi province, China. Concentrations ranging from 2 to 13 ng/m3 were observed. As uniquely enabled by the lidar technique, representative average concentrations, integrated ov
In this paper, the Gospel According to Mark is investigated in search for its ghosts and phantoms. In particular, Mk. 6 and the scene of Jesus walking on water, as well as the story about the empty tomb of Jesus in Mk. 16, are considered as haunted sites. However, rather than finding straight forward ghost stories, following Greco-Roman standards of late antiquity, we are confronted by a different
Objective: The aim of this study was to prospectively determine the incidence of medication-related osteonecrosis of the jaw (MRONJ) and define risk factors in patients with metastatic breast cancer treated with zoledronic acid and/or denosumab. Study Design: In a prospective cohort study performed in Region Skåne, Sweden, from January 1, 2012, until December 31, 2015, all patients with breast can
Introduction: While the relationship between hypertension and incident intracerebral haemorrhage is well established, other risk factors are less clear. This study examined risk factors for primary intracerebral haemorrhage, separately for lobar and non-lobar intracerebral haemorrhage. Patients and methods: Incidence of intracerebral haemorrhage was studied among 28,416 individuals from the popula
