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Biallelic CEBPA mutations and FLT3 length mutations are frequently identified in human acute myeloid leukemia (AML) with normal cytogenetics. However, the molecular and cellular mechanisms of oncogene cooperation remain unclear due to a lack of disease models. We have generated an AML mouse model using knockin mouse strains to study cooperation of internal tandem duplication (ITD) mutation in the
Utilities, such as steam and cooling water, are often shared between production areas at large-scale sites. A disturbance in the supply of a utility is therefore likely to affect a large part of a site, and cause great loss of revenue. This study focuses on identifying disturbances in utilities and estimating the economical effects of such disturbances. A general method for reducing the loss of re
A well-developed spatial memory is important for many animals, but appears especially important for scatter-hoarding species. Consequently, the scatter-hoarding system provides an excellent paradigm in which to study the integrative aspects of memory use within an ecological and evolutionary framework. One of the main tenets of this paradigm is that selection for enhanced spatial memory for cache
Utvecklingen inom det brandskyddstekniska området går snabbt vilket, tillsammans med nya byggföreskrifter, motiverar att denna handbok tas fram. Brandskyddslaget, Bengt Dahlgren Brand & Risk och Brandteknik LTH publicerar sedan några år Brandskyddshandboken som förklarar och förtydligar BBR:s brandskyddsavsnitt. Nu när BBR 21 med stora ändringar tillämpas, har vi tagit fram en ny uppdaterad o
(1) I explore the hypothesis that the water regime is one of the major determinants of the difference between bog and fen in Sphagnum mires because of its effects on the decay loss and the mass accretion rate. This article deals with the recent mass balance and water regime and the variation in mass accretion rate during the last millennium, studied at two mires in southern Sweden. (2) At one bog
Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the hepatic low-density lipoprotein receptor (LDL-R) and is therefore a prominent therapeutic target for reducing LDL-cholesterol. The C-terminal domain of PCSK9 is unlikely to be involved in a direct extracellular interaction with the LDL-R. We probed the importance of the C-terminus for the degradation of the LDL-R
An artificial key to the 122 Caloplaca species presently known for the Australian continent is provided.
Landscape patchiness creates aerodynamic transition zones that affect the exchange of nutrients and pollutants between the atmosphere and vegetation. Using an artificially-generated NaCl aerosol (mass-versus-particle-size distribution with aerodynamic mean particle diameter 1.6 mu m; geometric standard deviation 1.9), we investigated the forest-edge effect on aerosol deposition within a model oak
The exchange of carbohydrates and mineral nutrients in the arbuscular mycorrhizal symbiosis must be controlled by both partners in order to sustain an evolutionarily stable mutualism. Plants down-regulate their carbon flow to the fungus when nutrient levels are sufficient, while the mechanism controlling fungal nutrient transfer is unknown. Here we show that the fungus accumulates nutrients when c
The Swedish Family-Cancer Database has been the major source of population-based prospective data on familial risks on most cancers, including prostate cancer. In the present review, I focus on three lines of family studies with novel results. The covered studies originate from the same database with publication dates spanning a period of somewhat over 3 years. Age-specific hazard ratios (HRs) of
Duchenne muscular dystrophy (DMD) is the most common childhood myopathy, characterized by muscle loss and cardiorespiratory failure. While the genetic basis of DMD is well established, secondary mechanisms associated with dystrophic pathophysiology are not fully clarified yet. In order to obtain new insights into the molecular mechanisms of muscle dystrophy during earlier stages of the disease, we
Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants' profile. We intended to geo-map the target population and non-participation in an attempt to understand factors related to screening uptake and, thereby
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
