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Aims: Fluorescence in situ hybridization (FISH) can be used to reveal several genomic imbalances relevant to proper cancer diagnosis and to the correct treatment regime. However, FISH requires expensive and advanced fluorescence microscopes in addition to expertise in fluorescence microscopy. To determine whether a newly developed dual-colour chromogenic in situ hybridization (CISH) method is a su
To fully exploit the ultimate source properties of the next-generation light sources, such as free-electron lasers (FELs) and diffraction-limited storage rings (DLSRs), the quality requirements for gratings and reflective synchrotron optics, especially mirrors, have significantly increased. These coherence-preserving optical components for high-brightness sources will feature nanoscopic shape accu
The diversity and prevalence of malaria parasites of the genera Plasmodium and Haemoproteus were determined in the globally-threatened Aquatic Warbler Acrocephalus paludicola. Birds were sampled during migration in Portugal and at the wintering quarters in Senegal and parasites were detected using molecular methods. Only three generalist parasite lineages (Plasmodium) were found. There were no sig
Aim The northern limits of temperate broadleaved species in Fennoscanndia are controlled by their requirements for summer warmth for successful regeneration and growth as well as by the detrimental effects of winter cold on plant tissue. However, occurrences of meteorological conditions with detrimental effects on individual species are rare events rather than a reflection of average conditions. W
Reliable estimates of past land cover are critical for assessing potential effects of anthropogenic land-cover changes on past earth surface-climate feedbacks and landscape complexity. Fossil pollen records from lakes and bogs have provided important information on past natural and human-induced vegetation cover. However, those records provide only point estimates of past land cover, and not the s
Water availability is one of the most important factors for economic development in the Middle East. The Water Evaluation And Planning (WEAP) model was used to assess present and future water demand and supply in Syria till 2050. Nonconventional water resources, climate change, development, industrial growth, regional cooperation, and implementation of new water saving techniques/devices were cons
Abstract in Undetermined Authoritarian consolidation is conceptualised as a deliberate state project to improve a regime's capabilities for governing society. It is hypothesised that the durability of an authoritarian regime increases to the extent that regime elites manage to substitute coercion for governing by organisation, regulation and the management of discourses. This provides them with a
The surface and electronic structure of single crystal thin films of PtLuSb (001) grown by molecular beam epitaxy were studied. Scanning tunneling spectroscopy (STS), photoemission spectroscopy, and temperature dependent Hall measurements of PtLuSb thin films are consistent with a zero-gap semiconductor or semi-metal. STS and photoemission measurements show a decrease in density of states approach
Background. Psychotic-like experiences (PLEs) and juvenile mania in adolescence index risk for severe psychopathology in adulthood. The importance of childhood problems with communication, reading, speech and mathematics for the development of PLEs and juvenile mania is not well understood. Method. Through the Child and Adolescent Twin Study in Sweden, we identified 5812 children. The parents were
Simultaneous measurements of the t (t) over bar, W+W-, and Z/gamma* -> tau tau production cross-sections using an integrated luminosity of 4.6 fb(-1) of pp collisions at root s = 7 TeV collected by the ATLAS detector at the LHC are presented. Events are selected with two high transverse momentum leptons consisting of an oppositely charged electron and muon pair. The three processes are separated u
The accurate analysis of the seismic response of isolated structures requires incorporation of the flexibility of supporting soil. However, it is often customary to idealize the soil as rigid during the analysis of such structures. In this paper, seismic response time history analyses of base-isolated buildings modelled as linear single degree-of-freedom (SDOF) and multi degree-of-freedom (MDOF) s
The importance of lake ecosystems for waterfowl remains a topic of debate. In order to assess how temporal variations in lake features, specifically shifts between alternative stable states, may interact with the waterfowl fauna, we performed a long-term (22 years) study of the shallow Lake Krankesjon, southern Sweden. Lower total numbers of waterfowl occurred during periods with low macrophyte co
Activated Sludge Models are widely used for simulation-based evaluation of wastewater treatment plant (WWTP) performance. However, due to the high workload and cost of a measuring campaign on a full-scale WWTP, many simulation studies suffer from lack of sufficiently long influent flow rate and concentration time series representing realistic wastewater influent dynamics. In this paper, a simple p
We developed and validated a high-throughput human papillomavirus (HPV) serology method based on Luminex technology, using pseudovirions (PsVs) of eight mucosal HPV types (HPV 6, 11, 16, 18, 31, 45, 52 and 58) and two cutaneous HPV types (HPV 5 and 38) bound to heparin coated beads. Analysis with neutralising type-specific monoclonal antibodies against included HPV types indicated type-specificity
In this study, a new model framework that couples the atmospheric chemistry transport model system Weather Research and Forecasting-European Monitoring and Evaluation Programme (WRF-EMEP) and the multimedia fugacity level III model was used to assess the environmental impact of in-air amine emissions from post-combustion carbon dioxide capture. The modelling framework was applied to a typical carb
Congenital haemophilia A and B are genetic disorders affecting factor VIII and factor IX production, respectively. Factor replacement is the only effective treatment for these deficiencies, but a patient's immune system can develop inhibitory antibodies which bind and interfere with the function of the replaced factor in a variety of ways. The main treatment goal for patients with inhibitors is to
Lennartsson J, Ronnstrand L. Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications. Physiol Rev 92: 1619-1649, 2012; doi: 10.1152/physrev.00046.2011.-Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal tr
