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Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar K d values as determined by a competitive fluorescence polarization assay. A detailed thermodynamic analysis of the binding of D-galactosides to galectin-8N by isothermal titration calor
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The influence of environmental policy has been known to move beyond the country or regional contexts in which they have been implemented. Examples in literature include the “California effect” and the “Brussels effect”, showing how the policies adopted in the EU and California influence other jurisdictions. In this paper we study the following: To what extent are companies operating in the United
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Hippocampal atrophy on magnetic resonance imaging is an important biomarker in Alzheimer's disease (AD). While hippocampal atrophy was thought to result from tau tangles in AD, different neuropathologies can lead to hippocampal atrophy, especially TAR DNA-binding protein 43 (TDP-43) pathology. In this narrative review, we evaluate existing studies on the relative contribution of tau and TDP-43 pat
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Studio recordings of new music for serpent from the composers Orlando Bass, Henrik Denerin, Athena Corcoran-Tadd, and Jesse Ronneau, recorded at the Inter Arts Center (Malmö) on 8-10 February 2025.
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BACKGROUND: Sexual harassment (SH) is a persistent problem at workplaces around the world, including academia.OBJECTIVE: This study examines the association between SH and mental well-being among employees at Lund University (LU) in Sweden.METHODS: Data was obtained from a cross-sectional survey targeting all LU employees in 2019. SH exposure was measured using a ten-item scale capturing SH experi