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Aim: Predicting the time-activity curve (TAC) of [177Lu]Lu-DOTA-TATE for organs at risk and neuroendocrine tumours (NETs) is an essential element in the calculation of the absorbed dose (AD) and a critical step for individualising peptide receptor radionuclide therapy (PRRT) treatment planning. This study aims to predict the TAC of [177Lu]Lu-DOTA-TATE using a single quantitative image of [68Ga]Ga-
Background: Co-occurring substance use disorders, and mental disorders are associated with significant suffering, high risks of violent reoffending and relapse in both substance use and psychotic episodes. Treatment for co-occurring substance use disorders in forensic mental health settings would benefit from incorporating patients’ understanding of their disorders. Method: Using an interpretative
Living through war is more than surviving each day – it's rebuilding life, identity, and society in the shadow of constant threat.This volume offers a multidimensional portrait of Ukraine during the Russian invasion, bringing together real life stories, empirical research, and institutional analyses from scholars and practitioners at Zhytomyr Polytechnic State University and Lund University. It hi
Background: Our aim was to investigate change over time of passive range of motion (pROM) in the upper limbs of children with cerebral palsy (CP), treated or not treated with botulinum neurotoxin-A (BoNT-A). Methods: Data from 2000 to 2017 were collected from the Cerebral Palsy follow-up program and registry in Sweden (CPUP) for children with spastic or dyskinetic CP. Mixed models were used to ana
The lichen genus Lecanora is one of the largest genera of lichenized fungi. The core part of the genus is the L. subfusca group and within this group, Lecanora hybocarpa (Tuck.) Brodo, initially described from North America and thought to be endemic, has been reported from several European countries. However, the identity of these European specimens has been increasingly questioned. This study aim
Background Preserved ratio impaired spirometry (PRISm) and restrictive spirometry pattern (RSP) are associated with increased morbidity and mortality, but the underlying mechanisms are unclear. Impulse oscillometry (IOS) measures small airway function more sensitively than spirometry. We aim to study the prevalence of abnormal IOS findings in relation to three spirometry patterns (obstructive, PRI
Background: To evaluate whether integrating proteomics, metabolomics, and a cardiovascular disease specific polygenic risk score (CVD-PRS) in the SCORE2-Diabetes model improves sex-specific 10-year prediction of major adverse cardiovascular events (MACE) in individuals with type 2 diabetes (T2D). Methods: Genome-wide association study (GWAS), plasma proteomics (with the Olink Explore 3072 platform
Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life
Aim: Assess healthcare utilization and direct costs for heart failure (HF) during the first two years post-diagnosis across HF subgroups. Methods: This retrospective population-based study included patients with HF aged 40–90 years in Region Halland. HF subgroups were defined based on echocardiographic ejection fraction, including HF with reduced ejection fraction (HFrEF), mildly reduced ejection
Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)
Background: Myocardium at risk (MaR) can be evaluated by cardiovascular magnetic resonance (CMR) imaging using contrast-enhanced steady state free precession (CE-SSFP) in patients after ST-elevation myocardial infarction (STEMI). However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which
Purpose: To avoid over-treatment of prostate cancer patients following screening for elevated prostate-specific antigen levels, keeping patients on active surveillance has been suggested as an alternative to radical treatment. This means recurring visits for patients with low-grade cancer to monitor progression. Our aim was to develop an artificial intelligence-based model that can identify high-r
Respect and integrity are fundamental to effective psychiatric care, yet patient experiences of poor treatment remain a significant concern. This study explores patient perspectives on mistreatment within Swedish adult psychiatry through focus group interviews with representatives of patient and family organizations. Participants described systemic and interpersonal challenges that contribute to i
Research in computational mechanics is increasingly in search of methods that directly incorporate the information governed by data. Within these data-based methods, the data-driven mechanics approach seeks to replace conventional material models with discrete data sets. Offering immense potential in computational mechanics, where the simulation of complex mechanical systems is often challenging,
Background: Despite robust evidence that genetic factors substantially influence both osteoporosis development and fracture risk, current screening guidelines fail to incorporate genetic factors into risk-assessment protocols. This study aims to determine personalized screening ages for osteoporosis based on polygenic risk score (PRS). Methods: This prospective cohort study utilized data from 223,
