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Light-frame timber buildings are often stabilized against lateral loads by using diaphragm action of roofs, floors and walls. The mechanical behavior of the sheathing-to-framing joints has a significant impact on the structural performance of shear walls. Most sheathing-to-framing joints show nonlinear load-displacement characteristics with plastic behavior. This paper is focused on the finite ele
N2O is currently the third most important anthropogenic greenhouse gas in terms of radiative forcing and its atmospheric mole fraction is rising steadily. To quantify the growth rate and its causes over the past decades, we performed a multi-site reconstruction of the atmospheric N2O mole fraction and isotopic composition using new and previously published firn air data collected from Greenland an
The geo-political transition in 1989-91 had long term consequences for the European integration process. The integration and regionalisation processes following the transition resulted in a transformation of territorial borders in and around the region; the functions of the borders changed. Mobility is vital for these processes. This paper is based on a longitudinal study of the development of air
Near-edge x-ray absorption fine structure (NEXAFS) and resonant inelastic x-ray scattering (RIXS) measurements at the oxygen K edge were combined with theoretical spectrum simulations, based on periodic density functional theory and nuclear quantum dynamics, to investigate the electronic structure and chemical bonding in kaolinite Al2Si2O5(OH)4. We simulated NEXAFS spectra of all crystallographica
In this article, I scrutinize three art, design, and architecture projects engaging with “cultured,” or “in vitro,” meat (primarily muscle cells cultured outside of bodies) to illuminate the entanglements of academic and extra-academic environments that have characterized cultured meat’s history to date, and the conversations that this technology has spurred. In envisioning new ways of eating, and
We explain the composition of gold alloy particle seeded InGaAs nanowires in the nucleation limited regime. We use binary nucleation modeling to account for the nucleation of InGaAs from a supersaturated quaternary liquid alloy particle containing Au, In, Ga, and As. In our modeling we use realistic chemical potential differences between the seed particle and the nanowire. The chemical potentials
Hypertrophic cardiomyopathy (HCM) remains the leading cause of sudden cardiac death in the young. Early markers for HCM are important to identify individuals at risk. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis, and vascular endotheliopathy in the early stages of familial HCM in young patients. Twenty-three HCM patients, 16 HCM-ri
Objectives: Clinical trials have demonstrated the efficacy of vedolizumab in inflammatory bowel disease (IBD). However, these findings may not reflect the clinical practice. Therefore, we aimed to describe a vedolizumab-treated patient population and assess long-term effectiveness. Materials and methods: Patients initiating vedolizumab between 1 June 2014 and 30 May 2015 were identified through th
Frequent visitors at the psychiatric emergency room (PER) constitute a small subgroup of patients, yet they are responsible for a disproportionate number of visits and thus claim considerable resources. Their needs are often left unmet and their repetitive visits reflect their dissatisfaction as well as that of PERs' staff. Motivated by these dilemmas, this study systematically reviews the literat
Evaluation of anti-proliferative effect of BSA-1 and 32/26/2B in Y79 retinoblastoma cancer cells.
Dissociative double photoionization of cyclopropane is studied in the inner-valence region using tunable synchrotron radiation. With the aid of ab initio quantum chemical calculations the energies of dication states and their favoured fragmentation pathways are determined. These are compared to the experimental appearance energies of two-body fragmentation processes and to the kinetic energy relea
Investigations of the mechanisms of touch perception and decoding has been hampered by difficulties in achieving invariant patterns of skin sensor activation. To obtain reproducible spatiotemporal patterns of activation of sensory afferents, we used an artificial fingertip equipped with an array of neuromorphic sensors. The artificial fingertip was used to transduce real-world haptic stimuli into
Stem cell-based therapy for type 1 diabetes would benefit from implementation of a cell purification step at the pancreatic endoderm stage. This would increase the safety of the final cell product, allow the establishment of an intermediate-stage stem cell bank, and provide a means for upscaling β cell manufacturing. Comparative gene expression analysis revealed glycoprotein 2 (GP2) as a specific
BACKGROUND: Aggregate and risk-stratified perioperative mortality rates (POMR) are well-documented in high-income countries where surgical databases are common. In many low-income and middle-income country (LMIC) settings, such data are unavailable, compromising efforts to understand and improve surgical outcomes. We undertook a systematic review to determine how POMR is used and defined in LMICs
