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Amelogenin self-assembly is a critical step in enamel matrix organization, supporting the spatial confinement of transient ACP and orchestrating hydroxyapatite nucleation and ordered growth. Studies have demonstrated that amelogenin self-assembles into nanoribbons by forming an amyloid-like structure that matches the cross-β pattern observed in the developing enamel matrix. However, molecular dete

PURPOSE: RAD51, a central player in the response to DNA damage, has been suspected to contribute to tumour resistance to therapy. A single-nucleotide polymorphism, RAD51 135G>C, in the untranslated region of the RAD51 gene elevates breast cancer risk among BRCA2 carriers. In this study, it was investigated whether this polymorphism is related to prognosis of breast cancer and RAD51 protein express

Microplastics and nanoplastics (MNPs) are ubiquitous environmental pollutants with increasing implications for human health. While their presence in human tissues is established, the molecular mechanisms driving their potential neurotoxicity remain unclear. This study investigates the impact of polystyrene (PS) on amyloid protein misfolding and cellular metabolism using optical photothermal infrar

X-ray absorption spectroscopy (XAS) measurements were performed at the oxygen K-edge using aqueous solutions of succinic and maleic acids. Molecular dynamics simulations were employed to perform structural sampling and calculate the theoretical spectra using the framework of the density functional theory. When the pH was varied, the first peak in the XAS profiles exhibited different behaviors for

3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential or

Context. A growing number of white dwarfs (WDs) exhibit one or more signs of remnant planetary systems, including transits, infrared excesses, and atmospheric metal pollution. WD 1054-226 stands out for its unique, highly structured, and persistent photometric variability.Aims. We investigate the long-term stability and nature of the periodic signals observed in WD 1054-226 to better understand th

Craft is re-emerging in debates on improving contemporary work. A recurring theme in research on craft is its potential to thwart alienation, which is considered one of the central pathologies of modern work. Through a case study of the Swedish craft beer community, we examine craft’s potential for de-alienating work. Drawing on Jaeggi’s conception of alienation as a relation of relationlessness,

Lignins are aromatic polymers found in fibrous plants, and a major side-product of paper pulping. They are under exploited due to a combination of economic and technical challenges. Valorisation efforts aim to resolve this, but these rely on informative and reliable analytical feedback. The diverse and complex structures of compounds found in lignins makes analysis difficult. This thesis outlines

Rotating Detonation Combustors (RDCs) offer a promising alternative to conventional gas turbines by utilising continuous supersonic detonation waves for theoretical pressure-gain combustion, boosting thermal efficiencies significantly. However, developing reliable designs is exceptionally challenging because the extreme combustor environments restrict experimental sensors from capturing sub-micros

Systematisk genomgång av Åke Ohlmarks uppgifter om betygsättningen av hand doktorsavhandling i memoarvolymen "Doktor i Lund" (1980) visavi Filosofiska fakultetens humanistiska sektions protokoll 1937.

Drawing on fine-grained ethnographies from Bissau, Chile, China, Egypt, Ecuador and Nepal, this volume explores how politically, religiously and (sub-)culturally inspired Utopias motivate youth in the Global South to imagine, enact and embody what was missing in the past and present. As a fluid age cohort and a social category between childhood and adulthood – and hence with tenuous links to the s

Climate warming profoundly alters cryospheric hydrological cycles, exacerbating the challenge of simulating the poorly understood processes, particularly in complex, glacier- and permafrost-dominated headwater basins. This difficulty centers on accurately representing the compound runoff regimes generated by the complex, overlapping interactions between rainfall and multiple cryospheric melt proce

Nära relationer är avgörande för människors välbefinnande. Anknytningsteori utgår från att tidiga erfarenheter med omsorgsfigurer (oftast föräldrar) under uppväxten formar hur individer lär sig förstå sig själva, andra och omvärlden. Genom upprepade interaktioner med omsorgsfigurer i situationer präglade av distress utvecklar barn mentala bilder som liknar ett manuskript, som innehåller implicit kClose relationships are fundamental to human wellbeing. Attachment theory posits that early caregiving experiences shape how individuals come to understand themselves, others, and the world. Through repeated caregiving interactions in situations of distress, children develop script-like mental structures (i.e., attachment schemas). Attachment schemas, thus, hold implicit knowledge about availabili