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Ultraviolet radiation exposure and a fair pigmentation phenotype are well-established risk factors for primary cutaneous melanoma. However, the prognostic relevance of these risk factors is largely unexplored in metastatic disease. The aim of this study was to examine whether phenotypic characteristics and sun exposure patterns affect the prognosis of metastatic melanoma with immunotherapy availab
Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (EVs) containing the toxin. This study aimed to demonstrate the lethal effects of toxin-positive vesicles, and the importance of the Stx receptor, globotriaosylc
The songbird brain region called Cluster N has been implicated as important for low-light vision and/or the perception of Earth’s magnetic field for migratory orientation. This region of the visual Wulst is active in migratory songbirds under dim light conditions and an intact Cluster N is necessary for magnetic compass orientation in a nocturnally migrating songbird species. Given that magnetic f
This document has been developed as a comprehensive roadmap to the organization of paediatric and congenital echocardiography laboratories, as well as the governance of echocardiography services and training across Europe. The following key topics will be reviewed and discussed: (i) the setup and organization of paediatric and congenital echocardiography laboratories; (ii) staffing requirements fo
The article describes how a series of adaptions enabled us to carry out a controlled intervention study in 15 preschools, with 420 children and about 40 preschool teachers, during the Covid-19 pandemic restrictions. The original overarching aim of the study was to develop and evaluate an early math intervention supporting children from low-SES environments to develop basic mathematical skills. The
Rubidium triyttrium decafluoride (RbY3F10) is a relatively unexplored low-phonon-energy fluoride host for lanthanide luminescent centers that shares structural similarities with KY3F10. In this study, Eu3+-doped RbY3F10 nanocrystals were synthesized using a microwave-assisted solvothermal method, with phase selectivity systematically controlled by pH and complexing agents. Optimized conditions (de
Purpose: Soft tissue tumors (STT) are highly heterogeneous neoplasms with more than 100 recognized subtypes, many of which lack reliable diagnostic or prognostic markers. We aimed to evaluate the clinical utility of transcriptome sequencing [RNA sequencing (RNA-seq)] in classifying STTs and identifying prognostically relevant subgroups. Experimental Design: We performed RNA-seq on 704 tumors repre
Optimization of the photoemission blade type XBPM mostly performed to increase its resolution by increasing the readout signal current and by optimizing blades geometry. This requires tailoring of the XBPM for a particular undulator, making almost every XBPM unique at the Synchrotron Radiation facility. In many cases the calibration coefficient is gap dependent. To overcome those drawbacks an alte
Background and Aims: Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and cerebrovascular events (MACCEs). This study tested whether the cardiovascular benefit of CPAP occurs preferentially in high-risk OSA, characterized by greater OSA-
This work enhances conventional constitutive models for dynamic strain ageing (DSA) based on McCormick’s ageing-time evolution, which incorrectly predicts continuous hardening even within loading stages without plastic flow. An adapted evolution equation is proposed that ties ageing-time progression to the yield surface, ensuring that DSA develops only when dislocations are energetically inclined
This paper empirically investigates characteristics for three omnichannel delivery options to be environmentally sustainable in urban, suburban and rural areas. It is guided by two research questions: Which are the most CO2-efficient delivery options for different product types in urban, suburban and rural areas? Which carbon emission factors are most important to address in the different contexts
Purpose of review – Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem cell aging, growing evidence indicates that lymphoid failure reflects constraints operating across multiple levels of the hematopoietic system. This review frames age-associated
Drug use disorder (DUD) is distributed unevenly over geographical areas of Sweden. We explore, using geographically weighted regression, the proportion of this variation associated with community levels of genetic risk, social deprivation and urbanicity. In the 5983 Demographic Statistical areas (DeSOs) within Sweden, we predict DeSO prevalence from mean genetic risk for DUD, measured by the famil
Language-based assessments (LBAs), quantitative estimates of scientific constructs based on language, have advanced methods in the psychological and social sciences for more than a decade. LBAs based on individuals’ prompted descriptions analyzed with large language models to produce scores of their psychological states and traits have shown strong convergence with the corresponding rating scales
As competition has shifted from individual firms to entire networks, supply chain management has become central to operations research. The extensive body of related work has advanced both supply chain practice and management mathematics theory. Yet, sustainable supply chain management has not received the same depth of treatment. In this editorial, we argue that sustainability cannot simply be ad
This study aims to advance the understanding of class consciousness and its changeability during Swedish expeditions to Svalbard at the turn of the twentieth century. Drawing on diaries written by two participants who took part in expeditions to the High Arctic, the study explores the class consciousness of individuals occupying intermediate class positions within the class structure, but also why
Denna studie syftar att visa på kopplingar mellan konsumentåsikter mot generativ AI och undersöka fenomen såsom consumer resistance genom boycotting och andra konsumentdrivna initiativ mot företag som använder generativ AI. För att uppnå detta var tio individer intervjuade genom att använda elicitering i en semistrukturerad intervjumetod som vår huvudsakliga empiri. I intervjuerna var intervjupers
The SHREC detector, a cuboid array of silicon strip detectors, was developed by the Nuclear Structure Group at Lund University for use in superheavy element research at the focal plane of the Berkeley Gas-Filled Separator at the Lawrence Berkeley National Laboratory in Berkeley, USA. It consists of six detectors. The main implantation detector, the veto detector and the four surrounding ’box detec
