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Immune tolerance induction (ITI) to eradicate an immune response against factor VIII (FVIII) has been used in hemophilia A (HA) with various success rates, costs, and treatment burden. The present study aimed to identify markers predictive of ITI success. Data were accrued from 237 patients with severe HA (FVIII level < 1%), history of persistent FVIII inhibitors ≥ 1 BU/mL and having performed ITI
Factors limiting fat cell expandability remain scarcely explored, and comprehensive functional comparisons of adipose depots in humans are limited. In the present study, we collected visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) paired-samples from 22 patients with obesity undergoing elective Roux-en-Y gastric bypass surgery. Whole tissue samples were used to determine adipoc
BACKGROUND: Recent advancements in single-cell transcriptomic analyses have greatly expanded our understanding of cellular diversity in adipose tissue, indicating transcriptionally distinct subpopulations of adipocytes. Here we sought to rigorously test such heterogeneity at the protein level.METHODS: A data-driven imaging platform was tailored to assess cellular protein levels based on immunofluo
People spend much of their adult lives within organizations, where they experience varying degrees of voice, participation, and autonomy in their everyday work. The political consequences of how this everyday authority is organized, however, have remained largely unexamined. This thesis asks whether the way work is structured shapes employees' understanding of democracy and their participation
This thesis studies the analytic structure of steady two-dimensional water waves using methods from complex analysis. For incompressible, inviscid, irrotational flows, the velocity field can be described by a complex potential that is analytic in the fluid domain. This analytic structure allows the use of conformal mapping and analytic continuation techniques to study the geometry of the free surf
This thesis explores the use of birding citizen science data and statistical modelling methods to support the construction of indicators for human-nature relationships. Motivated by the broader aspirational framework of the Nature Relationship Index, the study investigates how voluntary bird observation records can be processed into spatial and temporal measures suitable for statistical analysis,
Tillämpningar är en del av alla matematikkurser i gymnasieskolan. Matematik kan tillämpas på många olika ämnen, däribland fysik. Frågorna som undersöktes i denna studie var hur tillämpningarna av matematik på fysik används i matematikundervisning i gymnasieskolan och lärarnas inställning till användandet av fysik i matematikundervisning. Detta gjordes via semistrukturerade intervjuer. Fem verksamm
This study explores how female managers in Icelandic technology companies describe their career journeys and the turning points that shaped their progression into senior management. Eight semi-structured interviews were conducted and analysed using the Gioia methodology. The findings show that none of these women planned their way into leadership. Instead their careers were shaped by unexpected op
Forensic pathology is a branch of medicine that aims to determine the manner and cause of unnatural, suspicious or unexpected deaths that require a legal investigation. An important part of determining the cause of death is the examination of the body through an autopsy. The purpose of this project is to evaluate whether machine learning algorithms can predict cause of death based on autopsy data.
Accurate estimations of regional CO2 fluxes are essential for understanding the global carbon cycle and further mitigating climate change. Satellite-based retrievals of column-averaged carbon dioxide (CO2) from the Orbiting Carbon Observatory 2 (OCO-2) offer a promising avenue for estimating carbon fluxes with atmospheric inversion systems, as they provide higher spatial resolution and observation
Toxic workplaces have received increased attention in line with an increased focus on employee well-being and the psychosocial work environment. The complexity of the phenomenon, in combination with its negative impact on both individuals and organizations, makes it an important subject to investigate. Recent research shows that a toxic work environment is the strongest predictor of employee turno
Since the digital art commission market is a new business model in the art industry, the discovery of potential mechanisms for setting digital art commission prices is considered limited. This research explores the mechanism between an artist’s reputation level by the number of followers and artwork prices in the online digital art commission market for an exploratory study of developing the prici
Drawing on Upper Echelons Theory and Institutional Theory, this study explores the relationship between CEO narcissism, expressed through public facing digital communications, and firm- level Environmental, Social and Governance (ESG) performance across distinct institutional contexts. While emerging literature connects executive use of social media to Corporate Social Responsibility, it remains u
The global fashion industry generates approximately 2.1 billion tonnes of greenhouse gas emissions annually, yet the circular business models and sustainability initiatives promoted as its primary environmental remedy have not translated into reductions in absolute production volumes or total consumption. This study investigates why through the lens of what we term the Circular Growth Paradox: the
This study explores how organizational culture, organizational learning, and leadership enable neuroinclusive practices in large Swedish high-technical multinational organizations. Despite growing interest in neurodiversity in recent years, limited research has examined how neuroinclusive practices develop and become integrated within organizations. The study draws on theories of organizational cu
The loss of regulatory control over radioactive material and sources poses great risks to public safety. Such a situation necessitates the development of protocols and methods for effective and accurate localisation, characterisation and securement of the materials. Mobile gamma spectrometry, particularly using vehicle-borne detectors, has emerged as a viable method for in-situ characterisation of
