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Importance Longitudinal data are crucial for understanding rapid population aging in East and Southeast Asia, yet challenges in establishing and managing infrastructures remain undocumented.Objective To investigate challenges and adaptations across longitudinal aging datasets in East and Southeast Asia and synthesize stakeholder-informed processes and recommendations to guide future study design
Background and ObjectivesThe number of older adults living alone is increasing globally, often with varied risks and resilience capacities. Digital technologies may help mitigate these risks, but their potential remains poorly understood. This review maps evidence on digital technologies in social and health care interventions for older adults living alone, focusing on technology types, functions,
BACKGROUND: Type 2 diabetes mellitus (T2DM) is common among people with HIV (PWH), although studies comparing T2DM-related complications in people with and without HIV (PWoH) remain limited. This was assessed using data from the Cohort Study on Morbidity and HIV in Sweden (COSMOHS).METHOD: Nationwide study including Swedish residents born 1930-2006, diagnosed with T2DM between 2010 and 2019, follo
Den här broschyren riktar sig till dig som vill veta mer om vad palliativ vård är och vad den kan göra för personer med allvarlig sjukdom eller vid tillstånd då livet är hotat.Palliativ vård fokuserar på livskvalitet och kan starta tidigt i sjukdomsförloppet och pågå parallellt med annan vård. Här får du veta mer om vad palliativ vård är och fördelarna med att påbörja den tidigt, oavsett om det är
The endothelin receptor antagonist atrasentan improved kidney outcomes in the SONAR trial for type 2 diabetes and chronic kidney disease (NCT01858532), though individual responses varied. To identify molecular biomarkers of atrasentan response and outcome, we conducted a nested case-control proteomics study (N = 180) within the SONAR trial population and identified urinary clusterin (uCLU) as the
Introduction: Strengthening Primary Health Care (PHC) is essential for building resilient and equitable health systems, but PHC faces barriers in implementation, resource allocation, and political prioritisation. This study aimed to develop a strategic roadmap to enhance PHC by identifying core values, priorities, and actionable strategies through expert consensus. Methods: A two-round Delphi stud
Globally, a substantial number of children experience various forms of parental maltreatment. Child protection agencies work to support these children and prevent further abuse or neglect, often through targeted interventions directed at the parents. Previous research has indicated that social workers may approach male and female perpetrators of maltreatment differently once a case is reported. To
This article examines the life and work of the Danish Catholic priest Peter Schindler through a biographical and microhistorical perspective. Particular attention is given to Schindler’s memoirs, written during his years at the German priestly college at Campo Santo Teutonico in Rome, where he lived from 1947 to the early 1960s. In these writings, Schindler portrays his residence in Rome as the fu
BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN,
A new breed of prophets-intermediaries and pastoral bros of an AI industry with metaphysical aspirations-has surfaced on the global stage during troubled times. They make great promises, offer predictions and warnings, and stake out directions for humanity. This article argues that they do so by invoking the implicit collective memory of the apocalyptic imaginary known from ancient Jewish apocalyp
The resilience performance of networked microgrids (NMGs) in disaster-prone areas, using a real-world testbed located in Lombok, Indonesia is explored in this paper. Given the increasing environmental pressures and energy security concerns in Indonesia, it is vital to improve the robustness and sustainability of decentralized energy infrastructures. We propose an optimization-based energy manageme
This thesis investigates core excited electronic states of molecules in gas phase. In particular, the resonanttransitions of ionised molecules, the site-selectivity surrounding Auger-Meitner decay, and the nuclear dynamicsthat may follow core excitation and ionisation.Background: Fundamental understanding of molecules and ions lay the groundwork for all future applicativescience and production. Fo
Breast cancer is the most common cancer in women. Lymphoedema in the arm is a well-known side effect of breast cancer treatment and ranks high among the serious concerns of survivors. Thus, it is important to diagnose arm lymphoedema at an early stage and start conservative treatment when lymphoedema is still minimal or mild, thereby preventing development or deterioration of arm lymphoedema. Scre
Questions: How did α-, β- and γ- plant diversity of coastal dune slack plant communities change over 37 years during a period of significant changes in conservation management practices?. Location: Ainsdale Sand Dunes National Nature Reserve, England. Methods: We surveyed plant communities in dune slacks at Ainsdale Sand Dunes National Nature Reserve at two time points: in 1985 and in 2022. This p
Digital technology has become an integral aspect of contemporary cities, especially with the rise of smart city initiatives. Over the past two decades, researchers and practitioners have studied the potential of large public screens, also known as urban screens, in transforming public spaces and shaping the urban experience. This article contributes to the debate by discussing urban screens in the
We introduce a two-phase quadratic integrate-and-fire (QIF) neuron whose membrane potential evolves according to two alternating Riccati equations within finite bounds. This simple extension removes the unphysical voltage divergence of the standard QIF model while producing realistic spike waveforms. Despite this modification, the system retains an exact low-dimensional description in the thermody
