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The radiative properties of clouds depend partially on the cloud droplet number concentration, which is determined by the concentration of cloud condensation nuclei (CCN) when the clouds are formed. In turn, CCN concentrations are determined by the atmospheric particle size distribution and their chemical composition. We use a novel Lagrangian modelling framework to examine the origins and history
Purpose – This study explores how a public client as a focal firm enables value co-creation through orchestration that includes navigating and bridging knowledge, business and innovation ecosystems. Design/methodology/approach – The research is based on qualitative methods, with 25 semi-structured interviews being conducted with client representatives and project partners from four completed const
This paper presents a lifetime assessment of a marine leisure vessel propulsion and charging architecture comprising Dual Active Bridge (DAB) converters and a threelevel Neutral Point Clamped (NPC) inverter with Boat-To-Grid (B2G) capability. Analytical lifetime models, combined with thermal-electrical simulations and realistic operating profiles, are used to estimate the durability of semiconduct
Forests and forestry are relevant for multiple uses and benefits. The increasing urgency of climate change warrants consideration of how to balance use of forests as a carbon sink and use of wood for products. Carbon sink benefits are recognized in climate science, international climate policy, and also integrated into, e.g. the EU’s climate mitigation pathways. Climate benefits of forest products
Background: Chronic limb-threatening ischaemia (CLTI) causes high rates of amputation and mortality. Objectives: To compare incidence, management and prognosis in hospitalised patients with CLTI with and without diabetes mellitus (DM) in 2001 and 2023. A secondary objective was to compare adherence to global vascular guidelines on risk factors between patients with and without DM in 2023. Design:
Preliminary results from the first archaeological excavations of Early Modern mercury-production sites at Idrija, Slovenia, confirm the use of ceramic vessels for mercury roasting following the techniques described in Agricola’s De re metallica, which was published in 1556.
Soil erosion poses a significant environmental challenge in Dehradun due to its complex, steep terrain, heavy rainfall, and rapid urbanization. This study employed a Google Earth Engine-based approach to assess the average soil loss annually using the Revised Universal Soil Loss Equation (RUSLE). The analysis used various factors, including rainfall-runoff erosivity (R), soil erodibility (K), slop
Plastic’s unique properties are vital for a sustainable future, but its excessive global use signifies consumer society’s wastefulness, often found in short-lived products. Plastic development has overlooked recycling needs, resulting in low material recycling due to a wide array of plastic types with varying additives, leading to recycling challenges. Research focused on thermoplastics aims to re
One of the structuring logics behind the creation of news beats is the geographical one: that is, national, foreign and local news desks. Foreign and local beats, in particular, have a lot in common: the coverage of different geographical contexts increases the diversity and plurality of views; reporting from geographical peripheries is always the costliest in terms of production; the audience is
Aims: Using a longitudinal approach, the aim of this study was to examine whether baseline engagement in arts and culture was associated with a decline from ‘Good’ to ‘Poor’ health at follow-up. Methods: Self-rated health (SRH) and engagement in six cultural activities among randomly selected Danish adults (⩾15 years) were assessed using data from the Danish Health and Wellbeing Survey in 2019. On
The criteria for Brief Resolved Unexplained Events (BRUE) are used to stratify the risk in infants presenting with apneic episodes. However, these criteria often classify a high proportion of infants as higher risk. This study aimed to investigate the etiology of apneic episodes, particularly those compatible with BRUE, and to assess whether age ≤60 days is associated with serious underlying condi
Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r
The case presents the Itajuru, a complementary municipal currency in the City of Cabo Frío used in the State of Rio de Janeiro, Brazil.The reader gains insight into the political and economic context in which the Brazilian municipal currencies are introduced, as well as the trade-offs of the various options for designing and governing a municipal currency. The case concludes by presenting students
This editorial introduces the special issue on the geography of innovation and sustainability transitions in the bioeconomy, situating the bioeconomy as a policy-driven transformation project with strong regional and multi-scalar implications. The special issue contains six papers that focus on different parts of the bioeconomy and employ a wide range of empirical approaches; jointly, they provide
UNLABELLED: In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting enzalutamide monotherapy from patients with high
Natural products originating from microorganisms have been an important source of many successful lead molecules in the drug discovery and development process. The technological advances in analytical instrumentation and the development of various omics methodologies have provided new opportunities to accelerate the discoveries of new lead structures of microbial origin. Metabolomics is a rapidly
Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer (BC) subtypes, as well as after enfortumab vedotin (EV) exposure, remains unknown. Using gene expression data from four clinical cohorts with >1400 pa
Objective: To assess the risk of suicide after a diagnosis of urinary bladder cancer (UBC) compared with the standard population and to identify potential risk factors and time dependence associated with suicide in patients with UBC. Method: We used data from the Bladder Cancer Data Base Sweden 2.0 (BladderBaSe), including all individuals aged 18 years or older, diagnosed with UBC between 1997 and
