Filetype
Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the origin of leukemia and a potential reservoir for relapse. Using primary human samples and gene editing to model isocitrate dehydrogenase 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, and metabolic differences bet
This study explores how listeners use verb constructions to describe everyday sounds. It considers (i) how the verb constructions provide Gestalt to events in the form of activities, processes and states, and (ii) how the constructions correspond to different aspects of a soundscape (sound sources, acoustic properties, and listener reactions). We found that verb constructions primarily describe so
OBJECTIVES: Penicillin V (PcV) is considered the first-line treatment for community-acquired pneumonia in Scandinavian countries, although data supporting this recommendation are scarce. Thus, this study aimed to compare PcV and amoxicillin regarding the risk of treatment failures in children aged >5 years and adults treated for pneumonia in primary care.METHODS: In this retrospective study of hea
Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unknown to what extent the organisation of general practice and national digital infrastructures have impacted the uptake and use of video consultations. O
Water resource recovery facilities face challenges with increasingly stringent effluent demands, complexity and demand for capacity increasing investments. Emerging technologies such as digital twins could alleviate these problems but require high frequency influent data. This work presents a method for utilising measurements in the primary clarifier effluent with a model of the processes between
Background: The ability of modern ultrasound machines to detect signs of enthesitis has increased, yet there is a lack of studies on patients with long-standing radiographic axial spondyloarthritis (r-axSpA). Hence, we aimed to investigate the prevalence and clinical significance of Doppler signals indicative of inflammation in peripheral entheses of patients with long-standing disease. Methods: P
Conventional diagnostic methods often involve long incubation times due to limited fluid mixing in confined spaces, despite offering high sensitivity. Therefore, acoustic streaming was employed to enhance microscale advection, thereby improving biomolecular interactions and reducing assay duration. The micromixing capability was demonstrated by dispersing methylene blue (MB) in deionized water and
Recent years has seen increasing interest in the concept of affordances in music performance research. Hereby, the agency of musical instruments is understood as defined by the perceived opportunities for action emerging through the sensorimotor relationship (i.e. the continuous interaction between musician and instrument). As such, it is an analytical perspective that highlights material and embo
Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit
Objective: Primary care is the base in many health care systems, and to identify the most registered diagnoses in primary care is a way to identify the overall health care use and needs in society. We estimated the rates of the 30 most common diagnoses in primary health care and their male to female ratio. Research design and methods: This was a study including inhabitants 18 years and older out o
Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. Those with PRKN mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of tau. Yet all three mutation types are i
This study aimed to investigate the potential impact of neighborhood deprivation on the incidence of type 2 diabetes mellitus (T2DM) among individuals with asthma. This nationwide, open cohort study conducted in Sweden from 1997 to 2018 included asthma patients of all ages (n = 1,051,240) to assess their subsequent risk of developing T2DM. The study compared asthma patients residing in highly depr
This work presents an alternative cetane rating method using a production compression ignition (CI) engine, offering an accessible approach for preliminary fuel evaluation without the need for specialized equipment. As part of this work, an empirical correlation was developed linking ignition delay (ID) to both the cetane number (CN) and intake oxygen concentration. The test method follows the pri
The Eocene period experienced several hyperthermal events with the Paleocene-Eocene Thermal Maximum being the most significant. During this event, global mean surface temperatures were 5–6 °C higher and latitudinal temperature gradients were reduced compared to the late Paleocene. Unlike marine temperature records, terrestrial archives are limited, posing challenges for testing climate model compe
Dietary fibers are recognized for their health benefits, yet cancer patients undergoing pelvic radiotherapy are often advised to reduce fiber intake. This may negatively impact their bowel health. To evaluate the effects of dietary fibers on bowel health post-irradiation, male C57BL/6 mice were fed diets containing either 0 or 15% fiber with varying proportions of readily fermentable bioprocessed
Introduction: Generalised anxiety disorder (GAD) in older adults involves excessive worry and cognitive challenges. Verbal memory impairments is associated to hippocampal dysfunction, with cortisol and brain-derived neurotrophic factor (BDNF) being important in hippocampal integrity. Research on hippocampal volume and verbal memory in older adults with GAD is limited, with mixed findings. This stu
Background: Countries around the world have committed to universal health coverage (UHC), a global vision that affirms the right for all people to access essential healthcare, when and where they need it and regardless of their ability to pay. UHC, as a political commitment, developed as part of the Sustainable Development Agenda in 2015 and, more recently, at the United Nations High-Level meeting
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns inde
