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The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of the envelope glycoprotein (Env) subunit gp41 and is among the broadest known neutralizing antibodies against HIV-1. Accordingly, this antibody and its mechanism of action valuably inform the design of effective vaccines and immunotherapies. 10E8 exhibits unusual adaptations

Amyloid protein deposits are the hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, or diabetes type II. Although their connection to the diseases is not fully understood, many studies point at intermediate species called oligomers as being the main responsible for the toxicity of these proteins. This makes them strong candidates as therapeutic targets. However, due to their

first_pageDownload PDFsettingsOrder Article ReprintsOpen AccessArticleDiagnostic Performance of Clinical and Routine Laboratory Data in Acute Mesenteric Arterial Occlusion—An International Multicenter Studyby Yasmin Soltanzadeh-Naderi 1ORCID,Annika Reintam Blaser 2,3ORCID,Martin Björck 2,4,Alexandre Nuzzo 5ORCID,Joel Starkopf 2,6,Alastair Forbes 2,Marko Murruste 2,6ORCID,Kadri Tamme 2,6ORCID,Peep

Background:Acute mesenteric venous thrombosis (MVT) is rarely suspected as primary diagnosis in emergency departments and still carries an in-hospital mortality rate of above 20%.Objectives:The aim of this study was to find differences in clinical and laboratory markers between patients with acute MVT and a control group of suspected but confirmed as not having any type of acute mesenteric ischaem

This chapter discusses how the official religious policies stipulated in the so-called Document 19 issued by the Central Committee of the Chinese Communist Party in 1982 have transformed into the current religious laws and policies under Xi Jinping. Therefore, it analyses the most recent amendment (2017) of the Religious Affairs Regulations (RAR), Administrative Measures for Religious Groups (2020

As late as in the 1970s, the evidence supporting that brain function might be restored by replacing dead cells by transplantation of new healthy cells was scarce in experimental animals and lacking in humans. Repairing the human brain was regarded as completely unrealistic by clinicians. Fifty years later, the situation is very different, and cellular grafting has reached patient application in se

This paper examines the history of entrepreneurship education (EE) in the United Kingdom (UK), exploring different forms and types as they have emerged over time. The study uses a wide range of sources, including both secondary (e.g. published papers, historical records of specific programmes, and enterprise policy documents) and primary accounts that document the lived experience of educators. It

This article addresses the problem of multi-target localization from acoustic time delay measurements in a 3-D underwater environment, taking into account the depth-dependent sound speed of the underwater wave propagation. Specifically, we formulate the problem as an optimal mass transport (OMT) optimization over a grid of potential candidate positions. By exploiting an iterative refinement approa

Repair and replacement strategies using cell replacement or viral gene transfer for neurologic diseases are becoming increasingly efficacious with clinically meaningful benefits in several conditions. An increased understanding of disease processes opens up opportunities for genetic therapies and precision medicine methods aiming at disease modification or repair of lesioned neurologic structures.

A person’s life chances and quality of life depend on social class distinctions, but more so on the region one grew up in. Perspectives of the ‘urban’ or ‘metropolitan’ are a starting point when discussing geographical inequalities vis-à-vis rural, peripheral regions. How disrupting these problems and challenges are on the one (urban) and the other (rural) end of the geographical scope depends on

BACKGROUND: Anastomotic leakage after rectal cancer surgery is linked to reduced survival and higher recurrence rates. While an aggravated inflammatory response may worsen outcomes, few studies have explored the combined effects of leakage and inflammation.METHODS: This is a retrospective multicenter cohort study including patients operated with anterior resection for rectal cancer in Sweden durin

The labor market integration of migrants, focusing on employment and job quality, differs notably across Southern and Continental-Northern European nations, often involving trade-offs. Nonetheless, little is known about whether these diverse migrant inclusion models in European labor markets extend to the combination of employment and overeducation. Additionally, the role of gender in this context

The term “charisma” is recognized as sociology's most successful export to common speech. While sociologists habitually dismiss popular uses of the word, we address its vernacularity head on as a worthy object of study and as a potential resource for conceptual development. Using machine learning, we locate “charisma” within the wider discursive field out of which it arises (and continues to arise

Tryckt version av föredrag från 2014 vilket utgör en kåserande översikt över skildringar av kungliga och adliga näsor inom skön- och facklitteratur.

BACKGROUND Reusing anaesthesia infusion-set components may reduce the climate impact from plastic waste and discarded medications. Infusion-set contents can be shielded from patient contact by single use of an infusion line fitted with dual antireflux valves, preventing retrograde entry of microorganisms, and eliminating the risk for patient-to-patient cross-contamination. However, infusion-set co

This paper investigates the use of decentralised control architectures with heterogeneous dynamics for improving performance in large-scale systems. Our focus is on two well-known decentralised approaches; the 'predecessor following' and 'bidirectional' architectures for vehicle platooning. The former, utilising homogeneous control dynamics, is known to face exponential growth in disturbance ampli

It is often argued that anisogamy causes alternative reproductive tactics (ARTs) to be more common in males than females. We challenge this view by pointing out logical flaws in the argument. We then review recent work on the diversity of female ARTs, listing several understudied types such as solitary versus communal breeding and facultative parthenogenesis. We highlight an important difference b

Background and purpose: Traumatic brain injury (TBI) is a major source of health loss and disability worldwide. Accurate and timely diagnosis of TBI is critical for appropriate treatment and management of the condition. Neuroimaging plays a crucial role in the diagnosis and characterization of TBI. Computed tomography (CT) is the first-line diagnostic imaging modality typically utilized in patient