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The continuous quest for materials capable of providing sustained release of antimicrobial drugs is particularly important for indwelling medical applications. In this study, we utilized amoxicillin as a model active pharmaceutical ingredient (API) to investigate the feasibility of using porous media – specifically, functionalized calcium carbonate (FCC) microparticles – as a primary drug carrier
Background: Cohort studies often use simple models, for example, completers-only or aggregated scores, to assess changes in imaging outcomes. With more data available, this introduces selection bias. Integrated analyses allow scores from multiple reading rounds; therefore, we assessed their effect on the change estimates’ precision compared with the completers-only analysis. Second, we compared ch
Contemporary Nordic building design prioritizes energy-efficient HVAC systems to mitigate carbon emissions. However, this approach underestimates intensifying climate risks, creating critical vulnerabilities as extreme weather and energy/resource scarcity escalate. To address this gap, a free-running building concept, eliminating heating, cooling, and mechanical ventilation, was examined for Nordi
Advances in biomarker technology, digital cognitive assessments, and amyloid-targeting therapies have redefined the opportunities for accurate and early diagnosis and care of Alzheimer's disease (AD). These advances also create new possibilities for intervention before the onset of cognitive impairment. This paradigm shift has increased the focus on Stages 1 and 2 of AD, in which individuals are c
The context of armed conflict situations presents unique challenges that can compromise the safety and well-being of both affected populations and responders in radiological and nuclear emergencies. The focus of the EU project RRADEW ‘Resilience to RADiological Events in Wartime’ (2024–2027) is to enhance nuclear Emergency Preparedness, Response and Recovery (EPR&R) systems by strengthening re
The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention, from long-established immunisation programs to emerging
Background: With this study, we aim to explore pre-operative probabilistic expectations (what does the patient realistically expect) and value-based expectations (what does a patient consider important), post-operative expectation fulfillment, and the relationship with post-operative satisfaction in shoulder arthroplasty (SA) patients. We hypothesized that higher expectation fulfillment is related
INTRODUCTION: Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons. METHODS: We included 223 participants from the PREVENT-AD cohort with self-reported measures of sleep, objective actigraphy measures of sleep, and positron emission tomography (PET) scans for AD pathology quant
I syfte att förstå queer världsskapande praktiker – skapandet av en värld som står i motsats till hegemonisk heteronormativitet – sammanställer denna avhandling ett rörigt och rörligt arkiv av autoetnografi, intervju och film och utvecklar en kulturell analys. Ett fokus på berättande praktiker tillåter mig att spåra hur berättelser formas och förmedlas inom bredare kulturella kontexter genom situeAiming to understand practices of queer worldmaking – a world counter to hegemonic heteronormativity – my thesis brings together living and moving archives of autoethnography, interviews, and films to develop a cultural analysis. A focus on storytelling allows me to trace how stories are shaped and communicated within broader cultural contexts through situated and everyday acts of telling stories.
Atopic dermatitis (AD) is a chronic skin disease associated with impaired quality of life. Evidence from Sweden on out-of-pocket expenses and productivity losses remains limited. This study assessed the burden of AD among adults in relation to health-related quality of life (HRQoL), work productivity, activity impairment, willingness to pay for symptom relief, economic outcomes, considering comorb
The article presents Fady Joudah’s Textu as an innovative combination of poetry (haiku) and communication technology (text messaging). The paper questions the traditional distinction between literature and other media, exploring how digital formats affect the understanding of “text” and the experience of reading. The authors of the article invoke intermedial theory (Lars Elleström, Beate Schirrmac
Background: First-line managers in healthcare operate in increasingly complex environments marked by high demands, rapid change, and limited resources. These conditions impact their health, leadership capacity, and the sustainability of their roles. While previous research has addressed various aspects of leadership in healthcare, there is a lack of studies focusing specifically on how first-line
Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) enables sensitive detection and staging of prostate cancer, yet its relationship with long-term survival remains unclear. This study aimed to assess whether total lesion volume (TLV) measured on [18F]PSMA-1007 PET/CT predicts overall survival (OS) in prostate cancer patients. Methods: A co
Amelogenin self-assembly is a critical step in enamel matrix organization, supporting the spatial confinement of transient ACP and orchestrating hydroxyapatite nucleation and ordered growth. Studies have demonstrated that amelogenin self-assembles into nanoribbons by forming an amyloid-like structure that matches the cross-β pattern observed in the developing enamel matrix. However, molecular dete
Air pollution is the world’s deadliest environmental risk factor. Yetthere is little effort to educate the public about personal exposureto pollutants such as particulate matter (PM). This paper presentsthe design and implementation of a portable sensor box (PSB) tocollect local, spatially highly resolved particulate matter data. Tocounteract common inaccuracies in mobile particulate matter mea-su
The European Commission defines the Green Transition as the transformation set out in the European Green Deal. Ensuring that this transition is just is both an ethical requirement and a practical condition for maintaining public support and policy effectiveness. This Perspective proposes a multidimensional framework for assessing justice in Green Transition policies, encompassing distributional, p
The evacuation of hospitals in the event of fires and similar emergencies can be a difficult endeavor. Patients usually require assistance, with a considerable number of them being unable to evacuate by themselves due to medical conditions or due to the treatment they are receiving. Assistance is to be provided by the healthcare staff in the affected ward, which means that their level of preparedn
Vad kännetecknar egentligen kapitalismen, hur fungerar den och varför är den så seglivad? Harvardhistorikern Sven Beckert reder ut begreppen på mer än 1 300 sidor.
The mountain front recharge (MFR) process significantly influences the movement of water and dissolved organic carbon (DOC) in alpine catchments. However, no existing watershed models can adequately simulate this process, hindering accurate quantification of streamflow and DOC dynamics. To address this gap, this study explicitly incorporated the MFR process into a watershed-scale integrated water–
The climate change in northern Europe is not only leading to more extreme weather events but also causing long dry summers. This affects the moisture content of the ground and the vegetation. Causing an increased number of wildfires within Germany posing a risk to the environment, society, and firefighters. Surface fire spread in wildfires can be influenced by several environmental conditions and
