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INTRODUCTION: Unraveling how Alzheimer's disease (AD) genetic risk is related to neuropathological heterogeneity, and whether this occurs through specific biological pathways, is a key step toward precision medicine. METHODS: We computed pathway-specific genetic risk scores (GRSs) in non-demented individuals and investigated how AD risk variants predict cerebrospinal fluid (CSF) and imaging biomar

A novel flamelet-generated manifold (FGM) model is introduced, encompassing ignition and flame propagation in ammonia/n-heptane dual-fuel combustion under reactivity-controlled compression ignition (RCCI) engine conditions. To generate the FGM mapping function (FGM tabulation) accounting for multiple combustion modes in RCCI combustion, a novel one-dimensional RCCI configuration (1D-RC) is propose

Introduction: Digital options for osteoarthritis (OA) treatment are increasingly available with high patient satisfaction and acceptability. Little is, however, known about physical therapists’ (PT) perception of this treatment modality. Objective: To investigate PT’s experience of delivering digital treatment for hip and knee OA using a smart-phone application. Method: Nine PTs (mean age 36 years

B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell acute lymphoblastic leukemia. Despite its essential role in immunity, the mechanisms regulating Pax5 function remain largely unknown. Here, we found that the NAD+-dependent enzyme SIRT7 coordinates B cell development through d

This article responds to the general neglect of legal culture in the study of climate mobilities. It presents a case study of climate mobilities in an unplanned settlement in Maputo, Mozambique, exploring how legal culture influenced residents’ decision-making processes as they navigated climate-related risks in their daily lives. We demonstrate that legal culture can facilitate climate mobilities

The Swedish Campaign for Nuclear Disarmament (SCND) fought the military’s plans to acquire Swedish nuclear weapons and protested the nuclear arms race, 1961–1967. This article presents SCND’s ideological orientation by focusing on temporalities. SCND saw the Second World War as a decisive event and tried to avert a crisis and a dystopia by manifesting remembrance of past nuclear detonations, and b

Background: Insects often show adaptive phenotypic plasticity where environmental cues during early stages are used to produce a phenotype that matches the environment experienced by adults. Many tropical satyrine butterflies (Nymphalidae: Satyrinae) are seasonally polyphenic and produce distinct wet- and dry-season form adults, providing tight environment-phenotype matching in seasonal environmen

The year 2015 marked a rupture in the post-war development of refugee reception and integration policies in Sweden. This rupture involved both a radical change in refugee policy and practice, and a rupture in the long-held collective self-image of Sweden as a country with generous reception and integration policies (Scarpa & Schierup 2018). This article responds to the question of how social wThe year 2015 marked a rupture in the post-war development of refugee reception and integration policies in Sweden. This rupture involved both a radical change in refugee policy and practice, and a rupture in the long-held collective self-image of Sweden as a country with generous reception and integration policies (Scarpa & Schierup 2018). This article responds to the question of how social w

Article in the booklet for the 7 CD box set:Lars-Gunnar Bodin: Retrospective Episodes 1960-1987Introduction to the electroacoustic pieces CYBO I and CYBO II.

Scholarship in peace and conflict studies is paying increasing attention to the role of the environment for conflict transformation and peacebuilding. However, a closer analysis on how different understandings of “nature” implicate policy proposals and approaches to peacebuilding is lacking. In this study, we provide a critical reflection on the diverse understandings and valuations of nature at t

The Cretaceous–Palaeogene (K–Pg) mass extinction about 66 Ma ago was one of Earth’s largest mass extinction events. The demise of calcifiers, among others, influenced biogeochemical cycles and changed the conditions for carbonate depo sition in the global ocean. This study addresses the sedimentology and carbonate microfacies of the Cerithium Limestone Member of the Rødvig Formation within the ren

In everyday activities where continuous visual awareness is critical such as driving, several cognitive processes pertaining to visual attention are of the essence, for instance, change detection, anticipation, monitoring, etc. Research suggests that environmental load and task difficulty contribute to failures in visual perception that can be essential for detecting and reacting to safety-critica

Background: Incorporating knowledge about human behaviour and the effect of the environment is a major goal for the design and engineering of human-centred autonomous vehicles. Systems that aim to establish a common interaction ground with humans require systematic modelling of empirically established behavioural norms customised to specific contexts. Aims: Focusing on aspects pertaining to visual

What identity does the post-2000s Inland Tibet Class (ITC) generation mean? How do Sinophone-Tibetan films articulate the expression of such identity? How does affective visuality mediate the cultural, political, and gender identity formation of female artists of the post-2000s ITC generation?Jinyan Zeng, a researcher at the Centre for East and South-East Asian Studies, Lund University, Sweden, in