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Aims: Individuals with type 1 diabetes (T1D) are typically diagnosed at a young age and exposed to lifelong hyperglycaemia. Despite improved metabolic control, the risk of vascular complications remains challenging. However, some individuals remain free from developing major diabetic complications even after long duration, so-called “escapers”. This study investigated transcriptomic biomarkers lin
High nutritional value Andean seeds—tarwi (Lupinus mutabilis), cañihua (Chenopodium pallidicaule), and quinoa (Chenopodium quinoa)—were subjected to solid-state fermentation with Levilactobacillus brevis DSM 1269. This strain can convert L-glutamic acid into the neurotransmitter GABA. Fermented tarwi exhibited the highest GABA production, at 4 mg/g sample, which correlates with its higher protein
Starch microspheres are employed in medicinal products as embolization agents and drug delivery vehicles. For the encapsulation of sensitive ingredients, mild cross-linking techniques are needed, prompting interest in physical cross-linking via starch crystallization. This study investigates starch microsphere formation and crystallization kinetics in aqueous two-phase systems (ATPS) with various
Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor-initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This study aimed to identify SqCC-specific key regulators that could eventually be used as new anticancer targets. Transcriptional and metabolomic data were gathered
Population-specific thresholds have not been defined for the levels of adiposity and systemic biomarkers that predict chronic health risks in people with restricted growth conditions. Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41 ± 14 years, height 1.30 ± 0.10 m, body mass 60.5 ± 18.3 kg,
Background: Many traumatic brain injury (TBI) treatment protocols, including the Lund concept, advocate the highest point of the subarachnoid space (typically the vertex) as the zero-reference point for intracranial pressure (ICP) and the level of the right atrium as the zero-reference point for mean arterial blood pressure (MAP). In 2017, at the Department of Neurosurgery in Lund, Sweden, the zer
Parasitoid wasps are major causes of mortality of many species, making host immune defences a common target of adaptive evolution, though such targets outside model species are poorly understood. In this study, we used two tests of positive selection to compare across three closely related Galerucella leaf beetles that show substantial differences in their phenotypic response to the shared parasit
Objective: To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO-2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE-GDM). Design: A cost-analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised controlled trial. Setting: Sweden, with risk-factor based sc
Denna artikel utvecklar ett metodologiskt ramverk för fältbaserad politisk filosofi som integrerar etnografisk undersökning med normativt teoribygge kring socioekonomisk orättvisa. Empiriskt baseras artikeln på kvalitativa intervjuer med individer som är beroende av kontanter i en allt mer digitaliserad ekonomi, en kontext där infrastrukturella reformer missgynnar socialt marginaliserade grupper.TThis article advances a methodological framework for field-based political philosophy that integrates ethnographic inquiry with normative theorising on socioeconomic injustice. Empirically, it draws on qualitative research with individuals reliant on cash in an increasingly digitalised economy, a context in which infrastructural reforms disproportionately disadvantage socially marginalised groups.
Background: In healthy hearts, left ventricular atrioventricular plane displacement (LVAVPD) measured by cardiac magnetic resonance (CMR) contributes to ∼60% of stroke volume. LVAVPD has been shown to correlate with maximal cardiac output and exercise capacity and is an independent predictor of outcomes in patients with heart failure. We aimed to assess if longitudinal pumping is altered, if LVAVP
Continuous-flow fixed-bed reactors effectively bridge laboratory research and industrial production. As the key component, the catalyst module must demonstrate high catalytic activity and rapid reactant distribution to maximize the catalytic turnover. Herein, a facile strategy is proposed to fabricate a microfibrous catalyst by decorating Cu single atoms (Cu1) on composite microfiber (CMF) made fr
In recent decades the average paternal age at childbirth has risen sharply. Many researchers from various disciplines are alarmed, as the offspring of older fathers have a higher risk of many diseases; however, previous studies lack a historical perspective. A new analysis shows that in many countries the current levels of average paternal age at childbirth were just as high in the past as today.
Introduction: Occupational balance is an important concept in occupational therapy. However, no validated Occupational balance assessments currently exist in Lithuania. This study aimed to examine the psychometric properties of the Lithuanian version of the Occupational Balance Questionnaire 11 (OBQ11-LT). Method: A total of 127 healthy adults completed the OBQ11-LT to evaluate construct validity.
Aim: To summarise key epidemiological and therapeutic research on osteoarthritis (OA) published between April 2024 and March 2025. Methods: A narrative review was conducted using the MEDLINE database, focusing on English-language studies involving human participants published between April 1, 2024 and March 31, 2025. Eligible studies included observational longitudinal studies, systematic reviews,
Integrated pest management (IPM) is an important tool for sustainable crop production. IPM includes a diversity of methods, e.g., the use of biological control agents (BCAs) for disease control or growth promotion. While there is an increasing interest in the use of BCAs, less is known about their environmental costs and benefits on wild species, such as wild crop relatives. For example, a BCA may
Femoral neck fractures (FNFs) are associated with loss of function in all ages and excess mortality. The societal costs are high. Treatment needs to be tailored based on fracture type, functional demand, and physiological age of the patient. Internal fixation is often preferred for undisplaced FNFs and for displaced FNFs in young patients. Anatomical reduction is essential, but slight valgus is ac
When developing a research roadmap for human behaviour in fires, it is necessary to identify areas that require additional research. A general overview – from a multidisciplinary perspective – of gaps in human behaviour in fires research across multiple contexts is missing. The goal of this paper was to perform a scoping review to identify research gaps and themes in all aspects of human behaviour
This study investigates how the seven core resilience principles are integrated into assessments of forest system resilience to natural or human-induced disturbances across engineering, ecological, and social-ecological resilience concepts. Following PRISMA guidelines, a literature search in the Web of Science database using the keywords “resilience”, “forest” and “ecosystem services” yielded 1828
Endophytic fungi, which reside within plants without causing disease, are recognized for their ability to produce bioactive metabolites with antibacterial, antifungal, and antioxidant properties, as well as their role in enhancing plant defense mechanisms. Due to these valuable traits, endophytic fungi have attracted significant attention in biotechnology and microbiology. The four endophytic
Background: Perioperative stress or discomfort in shoulder arthroplasty (SA) patients can be reduced using more individually tailored patient education and expectation management. Most published studies assess pain and function for the first time at 6 weeks or 3 months. Consequently, there is no thorough understanding of day-to-day recovery trajectories within the first postoperative weeks, hinder
