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The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors like sex and APOE -ε4 carriership, remains unclear. In this study, we examined these associations in a population of older adults without dementia and evaluated the potential of Aβ-PET for risk stratification. We included 1329 participants (56 % female)

Aerosol–cloud interactions (ACIs) are critical in modulating the Earth’s energy balance and water cycle at both regional and global scales. This study examines ACIs over the Indian subcontinent during 2003–2020 using the third edition of the satellite application facility on climate monitoring (CM SAF) cloud, albedo, and surface radiation dataset derived from advanced very high-resolution radiomet

Background Non-aneurysmal subarachnoid haemorrhage (NASAH) accounts for less than 20% of spontaneous subarachnoid haemorrhage (SAH). However, its epidemiological characteristics, risk factors and aetiology remain poorly defined. Methods All patients with spontaneous SAH admitted to a neurosurgical centre in Sweden over a 3.5-year period were prospectively enrolled in a database. Epidemiological da

Psykedelika har använts i tusental år i delar av världen i helande och ceremoniella syften. Idag görs det studier runt om i världen för att undersöka dess potentiella effekter på flertalet psykiatriska diagnoser. Psykadelika i samband med terapi också kallat psykedelika-assisterad terapi har visat sig vara en effektiv behandling mot bland annat depressioner och ångesttillstånd. Psykologen kan kommPsychedelics have been consumed in some parts of the world for thousands of years for healing and ceremonial purposes. Today, studies across the world are investigating their potential effects on a range of different psychiatric disorders. Psychedelics in conjunction with therapy, also called psychedelic-assisted therapy, have been shown to be an effective treatment for conditions such as depressi

De industriella restenergier som står för 90 \% av fjärrvärmen i Luleå kommer upphöra inom en snar framtid vilket ställer ökande krav på en kostnadseffektiv produktion för att bibehålla låga fjärrvärmepriser. Syftet med examensarbetet, som genomförts i samarbete med Luleå Energi, är att undersöka kostnadseffektiviteten av fjärrvärmeproduktionen i Luleå, att ta reda på vad standard i fjärrvärmebranThe industrial residual energy that covers 90 \% of the district heating demand in Luleå will be discontinued in the near future. This places additional demand on the cost efficiency of the production in order to maintain low district heating prices. The purpose of this master thesis, in collaboration with Luleå Energi, is to examine the cost efficiency of the district heating production in Luleå,

Denna studie analyserar behandlingspersonalens upplevelser av arbetsmiljö och yrkesroll inom Statens institutionsstyrelse (SiS). Genom en kvalitativ metod genomfördes semistrukturerade intervjuer med nio deltagare från olika roller och erfarenhetsnivåer. Syftet var att undersöka hur organisatoriska strukturer och psykosociala faktorer påverkar arbetet och välbefinnandet. Resultatet visar på en mån

Universities offer a variety of services to students, staff, and affiliates, traditionally managed through physical campus cards. However, increasing mobility requirements and the need for secure, interoperable digital identity solutions call for a modernized approach to service access. This paper introduces eduTAP, an open-source concept and software framework that builds on top of digital wallet

Obesity may exacerbate colorectal cancer (CRC) prognosis, yet previous studies have shown inconsistent findings due to methodological limitations. In this nationwide cohort study, we investigated the association between body mass index (BMI) on CRC recurrence and mortality, while examining the influence of demographic, clinical, and socioeconomic characteristics. From the Danish Colorectal Cancer

In the active exploration of novel biobased semicrystalline polyesters to replace petrochemical plastics, AB-type aromatic condensation polymerizations are relatively rarely investigated but gain growing attention due to the straightforward synthesis of AB-type monomers from diverse asymmetric biobased feedstocks. However, achieving high molecular weights through AB-type melt polycondensations is

The primary regulator of testicular function is the gonadotropin-releasing hormone (GnRH). This hormone is secreted in a pulsatile manner by hypothalamic neurons. GnRH stimulates the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. LH stimulates the synthesis of testosterone (T) after binding to specific receptors on Leyd

Ulvan is a polysaccharide most abundant in green macroalgae biomass. Investigation of ulvan confirmed the potential of the polysaccharide for food, pharmaceutical and chemistry applications, emphasising the beneficial properties of ulvan oligosaccharides. Efficient production of oligosaccharides requires action of ulvan lyases capable of ensuring polysaccharide enzymatic depolymerisation. The a

In renal cell carcinoma (RCC), a majority of the patients are today diagnosed incidentally due to the frequent use of cross-sectional imaging. This has resulted in the diagnosis of smaller tumours and less advanced tumour stages. Imaging for renal tumour diagnostics and staging aim to differentiate between benign and malignant disease and precise determination of primary tumour extent before decis

The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription. The execution of growth-suppressive AR transcriptional programs in prostate cancer (PCa) and the potential for reactivation remain unclear. Here, we use a ge

In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with

Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease that resists therapy targeting androgen signaling, the primary driver of prostate cancer. mCRPC resists androgen receptor (AR) inhibitors by amplifying AR signaling or by evolving into therapy-resistant subtypes that do not depend on AR. Elucidation of the epigenetic underpinnings of these subtypes could provide important

This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu

Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.