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The atrio-ventricular (AV) node is the primary regulator of ventricular rhythm during atrial fibrillation (AF). Hence, ECG based characterization of AV node properties can be an important tool for monitoring and predicting the effect of rate control drugs. In this work we present a network model of the AV node, and an associated workflow for robust estimation of the model parameters from ECG. The
The atrioventricular node (AVN) plays an important role in rate control during atrial fibrillation (AF). To further our understanding of the AVN function in AF, we present a model-based study, relating AVN electrophysiological characteristics to changes in RR series characteristics observed during treatment with rate control drugs. The dual-pathway physiology of the AVN was modelled using a networ
In a multicentre phase III study of disseminated malignant melanoma performed in Sweden and Norway, 326 patients were randomised to receive treatment with the combination dacarbazine [DTIC] (D) and vindesine (V) with or without the addition of cisplatin (P). D was given intravenously (i.v.) at a dose of 250 mg/m2 days 1-5 every 4 weeks and V was given i.v. at a dose of 3.0 mg/m2 day 1 weekly. P wa
Osteoarthritis (OA) is a very common disease, especially in the knee. It is characterized by the breakdown of articular cartilage but involves all parts of the joint. OA is usually diagnosed at a late stage when the articular cartilage has begun to disappear. What happens before these macroscopic alterations is to alarge extent unknown. In this thesis the focus is on articular cartilage and menisc
We have used grazing incidence X-ray absorption fine structure spectroscopy at the cobalt K-edge to characterize monolayer CoO films on Pt(111) under ambient pressure exposure to CO and O2, with the aim of identifying the Co phases present and their transformations under oxidizing and reducing conditions. X-ray absorption near edge structure (XANES) spectra show clear changes in the chemical state
This article examines early Boy Scout camps as events of national display and localized internationalism. By detailing how the camp culture of the Swedish Boy Scout movement facilitated transnational integration, the article shows that internationalism as localized practice can be observed in summer camp environments from the early days of the twentieth century. Reports from these early camps high
This empirical study adopts an institutional theory framework to analyze the interactions and complex dynamics of entrepreneurial ecosystems. While previous research investigated interactions between the different actors of the entrepreneurship ecosystem, little attention has been dedicated to understanding the impact of the interactions upon the ecosystem dynamics. Adopting a case study approach
Introduction: Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. Material and methods: This study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between 1 March and 30 June 2020 an
Aim: Bumetanide, a diuretic agent, that reduces intracellular chloride—thereby reinforcing GABAergic inhibition—has been reported to improve core symptoms of autism in children. Given the positive results reported from French trials of bumetanide in children with autism, we decided to evaluate its effects in a small-scale pilot study, in advance of a larger randomised controlled study (RCT). Metho
Aim: To study whether a specific cognitive profile can be identified for children born extremely preterm (EPT) by investigating: 1) strengths and weaknesses not revealed by Full-Scale IQ, 2) overlap between different cognitive deficits and 3) proportion of EPT children with multiple deficits. Methods: We analysed data from the 4th version of Wechsler Intelligence Scales for Children in EPT childre
Aim: To investigate the ability of the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III), scores to predict later Wechsler Intelligence Scale for Children—Fourth Edition (WISC-IV), performances in a cohort of children born extremely preterm. Methods: 323 children, born <27 gestational weeks, were tested with the Bayley-III at corrected age 2.5 years and with the WISC-IV at
Aim: To compare risk algorithms (HCMRisk-Kids, ECG Risk-score) in hypertrophic cardiomyopathy (HCM) without syndrome association (ns-HCM) and with Noonan-like syndromes (RAS-HCM). Methods: A national paediatric HCM cohort (n = 151), presenting <19 years of age, mean follow-up 13.3 years, from all Swedish centres of Paediatric Cardiology (presenting 1972–2015), with 41 RAS-HCM patients (61% males),
