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The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves into the structural intricacies of FLT3, the roles of activation loop mutants, and their interaction with tyrosine kinase inhibitors. Coupled with this,
BACKGROUND: Perinatal stroke refers to a diverse but specific group of cerebrovascular diseases that occur between 20 weeks of fetal life and 28 days of postnatal life. Acute treatment options for perinatal stroke are limited supportive care, such as controlling hypoglycemia and seizures. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured bra
Background: Inflammation is a driver of atherosclerosis and susceptibility to cardiovascular events. Objectives: The authors sought to evaluate whether high-sensitivity C-reactive protein (hsCRP) levels are associated with the prevalence of high-risk coronary plaques in patients with non–ST-segment elevation myocardial infarction (NSTEMI). Methods: PROSPECT (Providing Regional Observations to Stud
Phosphodiesterase-5 (PDE5) inhibitors have shown promise as anti-cancer agents in malignancies. However, their specific effects on gastric cancer (GC) and the underlying mechanisms remain elusive. Our aim was to investigate this by combining evidence from population-based studies with data obtained from in vivo and in vitro experiments. By combing a couple of nationwide Swedish registers, GC patie
Background: Emerging evidence indicates that gut inflammatory and immune response play a key role in the pathophysiology of stroke and may become a promising therapeutic target. However, the specific role of the microbiota-gut-brain axis in poststroke aphasia (PSA) patients remains unclear. Objectives: The aim of this study was to investigate the relationships among the gut microbiota, neuroendocr
This study systematically evaluates and meta-analyzes Mendelian randomization studies on the bidirectional causal relationship between Alzheimer’s disease (AD) and systemic diseases. We searched five databases, assessed study quality, and extracted data. Diseases were classified using ICD-11, and the meta-analysis was performed with RevMan 5.4. A total of 56 studies identified genetic links betwee
Background: The potential role of immune cells and the precise contributions of genes from various immune cells in the development of colorectal cancer (CRC) remains unclear. We aimed to investigate the potential causal relationships between specific immune cell genes and the development of CRC by performing Mendelian randomization (MR) analysis. Methods: The cis-expression quantitative trait loci
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide level. Our aim is to enhance understanding of familial risks in childhood nervous system cancers. Methods: We used the Swedish population and cancer data from years 1958–2021 to a
Background Opportunistic bilateral salpingo-oophorectomy (BSO) is recommended in women who have undergone a hysterectomy due to gynecological carcinomas and/or in women with genetic indications, especially for women who do not intend to conceive. However, there is ongoing debate about whether BSO should be recommended in premenopausal women, due to the early cessation of estradiol because of BSO w
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
The introduction of electric heavy trucks will lead to new charging power requirements on the power grid. This study examines how much charging power is required for the public fast charging of a fully electrified long-haul truck fleet. Probabilistic truck charging profiles are created using agent-based simulations, based on fully representative long-haul goods transport data from the study area.
The increasing global concern for greenhouse gas emissions has led to a fast pace in the transition away from fossil fuels in the transport sector. The share of electric passenger cars is increasing quickly, introducing new loads on the power grid. These loads primarily appear at the distribution grid level, where most of the charging occurs in the form of overnight charging at home. Although the
Aim: The aim of this study was to explore primary health care professionals' (PHCP) experiences of frailty assessment with the Tilburg Frailty Indicator (TFI) with focus on feasibility aspects. Background: Primary health care (PHC) is often the first point of contact for older people and assessment of frailty is therefore often recommended in this setting. There is however a lack of awareness of f
Background: Regular monitoring of healthcare quality and equity is crucial for informing decision-makers and clinicians. This study explores the application of generative AI, more specifically large language models (LLMs), to facilitate standardized monitoring of healthcare quality using the established framework Analysis of Individual Heterogeneity and Discriminatory Accuracy (AIHDA). The study i
