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Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with increasing disability and limitations in performance of activities of daily living (ADL) despite availability of effective symptomatic therapy. Following an overview of classical test theory (CTT) and Rasch measurement theory (RMT), the case of a clinical PD trial aiming to demonstrate ADL improvements by using th
An Inverse Heat Conduction Problem (IHCP) is considered in order to estimate the transient heat flux extracted from a hot solid surface by an impinging droplet. The resolution of the IHCP is made with the so-called quadrupole method, which provides an analytical expression of the temperature and the heat flux at the front surface of the solid wall, where the drop impact takes place. In the experim
This paper appraises the efficacy of using an analytical radial approximation for different thermal pile heat exchanger geometries. Unsteady radial heat-flow from fluid in a pipe set within a grouted borehole into the external ground is well-documented and can be solved analytically very rapidly using Laplace Transforms (Javed and Claesson 2011). By comparing the radial model with finite-element s
Although originally developed for fat globule disruption in dairy applications, high-pressure homogenizers are extensively used in other food processing applications. Two newer applications are in forming nanoemulsion for delivering supplemented nutrients and as a preservation technique, both using higher pressures than traditional applications. This has raised concern that friction heat created i
A big database (23 cases characterized by Damköhler number less than unity) created recently in 3D Direct Numerical Simulation (DNS) of propagation of a statistically one-dimensional and planar, dynamically passive reaction wave in statistically stationary, homogeneous, isotropic turbulence is analyzed. On the one hand, the DNS data well support the classical Damköhler expression, i.e., square-roo
Rainfall interception and other hydrologic processes affected by the forest litter layer are usually related to litter characteristics and rainfall conditions, with limited studies that consider the influence of slope. To simulate the hydrological functions of the litter layer at different slope gradients, artificial rainfall experiments were conducted at four rainfall intensities (from 30 to 120
This paper describes a method to synthesise wind turbine sounds to be used in sleep studies using a parameter-based synthesis. The parameter values were determined using recordings of several types of operating wind turbines, thorough investigations of the recorded sounds, previous reports on wind turbine sound characteristics, and acoustic knowledge on how sound properties change from source to a
Coagulation, complement, and innate immunity are tightly interwoven and form an alliance that can be traced back to early eukaryotic evolution. Here we employed an ecoimmunological approach using Tissue Factor Pathway Inhibitor (TFPI)-1-derived peptides from the different classes of vertebrates (i.e. fish, reptile, bird, and mammals) and tested whether they can boost killing of various human bacte
An approach to reduce CO2 emissions while simultaneously keeping the soot emissions down from compression ignition (CI) engines is to blend in short chained oxygenates into the fuel. In this work, two oxygenated fuel blends consisting of diesel, biodiesel and EtOH in the ratio of 68:17:15 and 58:14:30 has been utilized and studied in a single cylinder light duty (LD) CI engine in terms of efficien
For better understanding of the transient behavior of the flow/flame interaction in highly turbulent premixed flames, measurement techniques with sufficient temporal resolution are required. Using a burst-mode laser pumped optical parametric oscillator system, the present work demonstrated an ultra-high-speed diagnostic, for the first time, capable of visualizing hydroxyl radicals (OH) and formald
In this paper, NaCl pellets are produced in-house from ordinary household salt using simple and accessible methods, for the purpose of suggesting a cost-effective and available tool for various optically stimulated luminescence dosimetry applications. First, the pellets are investigated in terms of optimal configuration by varying combinations of grain sizes and compression forces. Then, the pelle
Register-based studies have indicated that men with impaired fertility are at higher risk for developing various adult-onset diseases than fertile men. The majority of men undergoing ICSI treatment are sub-fertile and since they are in contact with the health care system, these men are well suited as target for preventive measures. Our study included all men (N = 459 766) who had fathered children
Inflammation has been implicated in the pathogenesis of Parkinson’s disease (PD). We here investigate levels of inflammatory biomarkers in cerebrospinal fluid (CSF) in PD and atypical parkinsonian disorders (APD) compared with neurologically healthy controls. We included 131 patients with PD and 27 PD with dementia (PDD), 24 with multiple system atrophy (MSA), 14 with progressive supranuclear pals
Alpha 2-macroglobulin (A2M) is a protease inhibitor that has been reported to neutralize thrombin, which may decrease the risk of thrombosis. A 5-base pairs (bp) insertion/deletion polymorphism (rs3832852) at the splice acceptor site of exon 18 has been shown to affect the binding of A2M with proteases. However, the role of this important variant in A2M in recurrent VTE is unknown. We investigated
A flamelet tabulation method for partially premixed flames is proposed, in which partially premixed flamelets are incorporated as the archetypal flamelet elements. This method considers triple flame structures with both the partial premixing of fuel in the oxidizer side and the partial premixing of oxidizer in the fuel side, by replacing the pure-air and pure-fuel in the counterflow diffusion flam
Programming robots for tasks involving force interaction is difficult, since both the knowledge of the task and the dynamics of the robots are necessary. An immersive haptic interface for task demonstration is proposed, where theoperator can sense and act through the robot. This is achieved by coupling two robotic systems with virtual constraints such that they have the same coordinates in the ope
To compare clonal evolution in tumors arising through different mechanisms, we selected three types of sarcoma—amplicon-driven well-differentiated liposarcoma (WDLS), gene fusion-driven myxoid liposarcoma (MLS), and sarcomas with complex genomes (CXS)—and assessed the dynamics of chromosome and nucleotide level mutations by cytogenetics, SNP array analysis and whole-exome sequencing. Here we show
The Chinese government has launched a guideline to lead power plants to more suitable technological pathways for meeting the strict “ultra-low emission” (“ULE”) standards to reduce air pollution emissions of the coal-fired power industry. Considering the complex interrelations between water, energy and emission, a quantifiable method of choosing the feasible technology sets for 6 multi-objective o
