Design and Synthesis of C7-N-acetylneuraminic Acid Analogues as Potential Bacterial Sialic Acid Transport Inhibitors
Sialic acids or glyconic structures containing a sialic acid fragment are among the most abundant host surface molecules, typically found to be terminating branches of N-glycans, O-glycans, and glycosphingolipids (gangliosides). They play a crucial role in bacterial pathogenesis, due to the ability of bacteria to engage in molecular mimicry - the decoration of their surface with sialic acids - to
