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Centrifugal sedimentation of an ideal suspension in a rotating tube or basket can be modelled by an initial-boundary-value problem for a scalar conservation law with a nonconvex flux function. The sought unknown is the volume fraction of solids as function of radial distance and time for constant initial data. The method of characteristics is used to construct entropy solutions. The qualitatively
BACKGROUND: It is still not clear whether anastomotic leakage after anterior resection for rectal cancer affects long-term functional outcome. OBJECTIVE: This study aimed to evaluate how anastomotic leakage following anterior resection for rectal cancer influences defecatory, urinary, and sexual function. DESIGN: In this retrospective population-based cohort study, patients were identified through
AbstractThis thesis investigates the use of digital resources in education with a 1-1 computer to student ratio. Studies were performed with a sociocultural perspective and in the light of the theory of affordances. The two studies differ methodologically but the shared topic is teachers’ usage of digital resources. Previous studies have shown that using digital resources to promote collaboration,
Tidal inlets are narrow channels connecting coastal lagoons to the sea and in this way controlling the exchange of water while serving as navigational pathways. These important components of the coast are also very dynamic environments, having their morphology determined by multiple sediment transport processes, making tidal inlets difficult to model. Expected future se
This thesis contributes to econometric methodology in terms of estimation and inference in static panel data models with unobserved multidimensional heterogeneity. When not properly accounted for, unobserved heterogeneity may introduce bias into the parameter estimates associated with covariates of interest, such as treatment indicators or determinants of macroeconomic indicators. A common way of
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine–adenine–guanine triplet repeat in the huntingtin gene. The current diagnosis is based on the presence of typical motor signs in combination with a positive gene test. The motor onset of the disease is usually between 30 and 50 years of age, and the disease then progresses over around 20 more years. No
The antibody drug conjugate trastuzumab-emtansine (T-DM1) offers an additional treatment option for patients with HER2-amplified tumors. However, primary and acquired resistance is a limiting factor in a significant subset of patients. Hypoxia, a hallmark of cancer, regulates the trafficking of several receptor proteins with potential implications for tumor targeting. Here, we have investigated ho
Two methods for reconstructing intragranular strain fields are developed for scanning three-dimensional X-ray diffraction (3DXRD). The methods are compared with a third approach where voxels are reconstructed independently of their neighbours [Hayashi, Setoyama & Seno (2017). Mater. Sci. Forum, 905, 157-164]. The 3D strain field of a tin grain, located within a sample of approximately 70 grain
Genetic factors are often overlooked in conservation planning, despite their importance in small isolated populations. We used mitochondrial and microsatellite markers to investigate population genetics of the adder (Vipera berus) in southern Britain, where numbers are declining. We found no evidence for loss of heterozygosity in any of the populations studied. Genetic diversity was comparable acr
En analys av Agnieszka Hollands film Mörkret som handlar om förintelsen i Lviv/Lwow.
Background: CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer's disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use as clinical diagnostic tools. CSF tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker for Alzheimer's disease pathology. We aimed to assess whether blood p-t
The relaxation systems are an important subclass of the passive systems that arise naturally in applications. We exploit the fact that they have highly structured state-space realisations to derive analytical solutions to some simple H-infinity type optimal control problems. The resulting controllers are also relaxation systems, and often sparse. This makes them ideal candidates for applications i
This paper proposes a convex approach to the Frisch-Kalman problem that identifies the linear relations among variables from noisy observations. The problem was proposed by Ragnar Frisch in 1930s, and was promoted and further developed by Rudolf Kalman later in 1980s. It is essentially a rank minimization problem with convex constraints. Regarding this problem, analytical results and heuristic met
We study the problem of distance-based formation shape control for autonomous agents with double-integrator dynamics. Our considerations are focused on exponential stability properties. For second-order formation systems under the standard gradient-based control law, we prove local exponential stability with respect to the total energy by applying Chetaev's trick to the Lyapunov candidate function
Machine and reinforcement learning (RL) are increasingly being applied to plan and control the behavior of autonomous systems interacting with the physical world. Examples include self-driving vehicles, distributed sensor networks, and agile robots. However, when machine learning is to be applied in these new settings, the algorithms had better come with the same type of reliability, robustness, a
