Search results

To define the mutation spectrum in non-Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples. Our analysis identified a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric

The most prevalent xylose-assimilating pathways in recombinant Saccharomyces cerevisiae, i.e. the xylose isomerase (XI) and the xylose reductase/xylitol dehydrogenase (XR/XDH) pathways, channel the carbon flux through the pentose phosphate pathway and further into glycolysis. In contrast, the oxidative and non-phosphorylative bacterial Weimberg pathway channels the xylose carbon through five steps

The gene encoding the Escherichia coli FimH adhesin of type 1 fimbriae has been subjected to linker insertion mutagenesis. Amino acid changes were introduced at a number of positions spanning the entire sequence in order to probe the structure-function relationship of the FimH protein. The effect of these mutations on the ability of bacteria to express a D-mannose binding phenotype was assessed in

Most Escherichia coli isolates can express type 1 fimbriae with mannose- specific adhesins. These adhesins bind to the oligosaccharide chains of secretory immunoglobulin A (IgA). Thus, in addition to specific antibody activity, secretory IgA possesses a broad reactivity with bacteria expressing type I fimbriae. The absence of secretory IgA in colonic secretions, as seen in IgA deficiency, might th

Human body pose and shape estimation is an important and challenging task in computer vision. This paper presents a novel method for estimating 3D human body pose and shape from several RGB images, using detected joint positions in the images and based on a parametric human body model. Firstly, the 2D joint points of the RGB images are estimated using a deep neural network, which provides a strong

With the advent of cheap sensors and computing capabilities as well as better algorithms it is now possible to do structure from motion using crowd sourced data. Individual estimates of a map can be obtained using structure from motion (SfM) or simultaneous localization and mapping (SLAM) using e.g. images, sound or radio. However the problem of map merging as used for collaborative SLAM needs fur

Prevention, prediction, control, and handling of bacterial foodborne diseases – an ongoing, serious, and costly concern worldwide – are continually facing a wide array of difficulties. Not the least due to that food matrices, highly variable and complex, can impact virulence expression in diverse and unpredictable ways. This review aims to present a comprehensive overview of challenges related to

Burkholderia pseudomallei is resistant to a wide range of antibiotics, leading to relapse and recrudescence of melioidosis after cessation of antibiotic therapy. More effective immunotherapies are needed for better management of melioidosis. We evaluated the prophylactic potential of the immunogenic outer membrane protein Omp85 as a vaccine against murine melioidosis. Immunization of BALB/c mice w

In this paper we introduce a fast and robust structure-less alternative to full bundle adjustment. The method is based on optimizing algebraic errors for trilinear constraints from triplets of views. It is shown that the error generated by a triplet of views can be described by a fixed triangular matrix regardless of the number of feature correspondences between the views. The method has been eval

Burkholderia pseudomallei is the etiological agent of melioidosis, a severe infectious disease of humans and animals. The role of the bacterium's proteins expressed in vivo during human melioidosis continues to remain an enigma. This study's aim was to identify B. pseudomallei target proteins that elicit the humoral immune response in infected humans. A small insert genomic expression library was

We provide theory for the computation of convex envelopes of non-convex functionals including an ℓ2-term and use these to suggest a method for regularizing a more general set of problems. The applications are particularly aimed at compressed sensing and low-rank recovery problems, but the theory relies on results which potentially could be useful also for other types of non-convex problems. For op

This note comprises a synthesis of certain results in the theory of exact interpolation between Hilbert spaces. In particular, we examine various characterizations of interpolation spaces and their relations to a number of results in operator theory and in function theory.

Background: Few tools evaluates quality of movements in individuals with knee osteoarthritis (OA). The Test for Substitution Patterns (TSP) is developed to measure the ability to perform five functional movements regarding postural control and altered movement patterns (1). TSP is validated and reliable in individuals with anterior cruciate ligament injury, but has not yet been evaluated in indivi

The scFv antibody towards the Burkholderia pseudomallei exotoxin was previously constructed by phage display and exhibited good specificity towards the exotoxin. We report here the optimization of the scFv expression in an E. coli expression system. Four different E. coli strains (ER2537, TG1, HB2151, and XL1-Blue) were examined for optimal expression of the scFv protein. Two types of carbon sourc