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Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on

□ The Nordic Arthroplasty Register Association (NARA) was established in 2007 by arthroplasty register representatives from Sweden, Norway and Denmark with the overall aim to improve the quality of research and thereby enhance the possibility for quality improvement with arthroplasty surgery. Finland joined the NARA collaboration in 2010. □ NARA minimal hip, knee and shoulder datasets were created

A tiny larva of ʻOrstenʼ-type of three-dimensional preservation has been recovered from the Upper Cambrian Bitiao Formation of Wangcun section, western Hunan, South China, herein in- terpreted as an orthonauplius stage of a crown-group crustacean. The specimen comprises an ovoid body with a prominent labrum and three pairs of appendages. In all it exhibits comparable morpho- logical similarities w

Ammonia (NH3) is regarded as one of the most viable alternatives to produce carbon-free energy. However, its low flammability and high NOx emissions associated with its combustion inhibit the implementation of pure NH3 as a fuel. Dual-fuel approaches with NH3 and more reactive fuels have been proposed; however, information on pollutant emissions is still scarce. The present work focuses on quantif

The housing sector is important for achieving ambitious environmental targets. In the European Union, buildings account for 40% of energy consumption and 36% of CO2 emissions. Considering the scale of the housing sector's environmental impact, interventions in how new housing is built and existing housing is renovated have great potential for sustainable transformation. However, the sector has not

Fire evacuations at wildland-urban interfaces (WUI) pose a serious challenge to the emergency services, and are a global issue affecting thousands of communities around the world. This paper presents a multi-physics framework for the simulation of evacuation in WUI wildfire incidents, including three main modelling layers: wildfire, pedestrians, and traffic. Currently, these layers have been mostl

Treated bamboo can be made into large, durable structural elements which have the potential to become a transformative large-scale building material, but the fracture behaviour which determines their ultimate strength in various loading scenarios has not been studied. Laminated bamboo is a promising structural engineered bamboo material, and is generally made from bamboo treated to improve its dur

In order to characterize the radium distribution and submarine groundwater discharge (SGD) in the Bohai Sea area, the three isotopes 223Ra, 224Ra and 228Ra in different water bodies were measured in a 4-year period with the radium-delayed coincidence counting (RaDeCC) system. The results indicated that radium activities take an order of groundwater > coastal seawater > river water > central seawat

Denna femte studie behandlar Supply chain information sharing (SCIS), d.v.s. hur företag delar information i försörjningskedjan. Vi försöker också förstå hur företag delar information i försörjningskedjan - både mellan företagets interna avdelningar/funktioner och med viktiga partners. Analysen bygger på svar från 34 panelmedlemmar.

The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision-makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an

Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulate

Den sjätte studien är fokuserad på Supply chain risk management (SCRM), d.v.s. vi försöker förstå hur företag identifierar, analyserar och hanterar risker i sin försörjningskedja. Det gäller både i Risk Management i interna logistikflöden (egna lager, egna fabriker, transporter mellan egna anläggningar etc) men framför allt Supply Chain Risk Management i externa försörjningskedjor (leverantörer, u

Air cavities and gaps between material layers are common in construction systems, e.g. ventilated façades. Air cavity may provide a pathway for smoke and flame spread in case of fire. Performing physical testing to investigate different systems and fire scenarios is resource demanding. Fire Dynamics Simulator (FDS version 6.7.0) was used to simulate fire driven flow between two parallel vertical w

There is increasing evidence that environmental manganese (Mn) exposure early in life can have negative effects on children's neurodevelopment and increase the risk of behavioral problems, including attention deficit hyperactivity disorder (ADHD). Factors that may contribute to differences in sensitivity to Mn exposure are sex and genetic variation of proteins involved in the regulation of Mn conc

Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and

Per- and polyfluoroalkyl substances (PFAS) are extremely persistent manmade substances. Apart from exposure through food and indoor air and dust, humans can be exposed through drinking water if the surface or groundwater is contaminated. In 2013 very high levels of PFOS and PFHxS were found in the drinking water from one of the two waterworks supplying the municipality of Ronneby, Sweden. A cohort

The discovery of collectivity in proton–proton collisions, is one of the most puzzling outcomes from the first two runs at LHC, as it points to the possibility of creation of a Quark–Gluon Plasma, earlier believed to only be created in heavy ion collisions. One key observation from heavy ion collisions is still not observed in proton–proton, namely jet-quenching. In this letter it is shown how a m

Typhoon Haiyan hit the Philippines on 8th November 2013 destroying more than 1 million houses and affecting mostly the poor. This paper discusses user involvement in housing recovery from a capability perspective. The paper also analyses possibilities for extension of the housing solutions. Based on the Sphere handbook and the theoretical framework, a Model for user involvement in evolutionary hou

Purpose: Hardly anything is known about the aetiology of thymoma. This paper presents data regarding tobacco smoking and alcohol consumption in relation to thymoma from the first case-control study performed on this rare tumour. Methods: A European multi-centre case-control study including incident cases aged 35–69 years with thymoma between 1995 and 1997, was conducted in seven countries. A set o

Rapporten är en slutrapport för projektet ”Mätsystem för förändringsarbete”.Projektet syftar till att ta fram ett ramverk för mätning av förändringsarbete. Det innebär att ett mätsystem har utformats, implementerats, används och utvärderats i relation till Trafikverkets processer och avsikten med förändringsarbetet. Detta har skett genom en aktionsforskningsansats därforskarna samarbetat med två o