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Hedgehog (Hh) signaling is essential for embryonic development and tissue homeostasis in organisms. However, Caenorhabditis elegans lacks canonical Hh signaling due to the absence of key components, such as smoothened (SMO) and obvious Hh ligands. Despite this, C. elegans retains Patched homologs, ptc-1 and ptc-3, which have specialized independent functions. Although ptc-1 is predominant
Background: Percutaneous coronary intervention (PCI) is frequently used in the treatment of chronic coronary syndrome (CCS), although its impact on long-term prognosis and symptom relief remains debated. Among patients undergoing revascularisation with PCI, data on clinical outcomes following drug-coated balloon (DCB) based PCI in unselected patient populations is limited, and the comparative effe
AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after
CVD (chemical vapor deposition) coated cutting tools typically exhibit thermal cracks caused by the mismatch in coefficients of thermal expansion (CTEs) between coating and cemented carbide. These cracks act as weak points during stainless steel machining, contributing to premature tool wear. As a strategy to suppress thermal cracks formation, we investigate replacing the conventional cemented car
ackground: Exclusive breastfeeding during the first six months of life is a global public health recommendation and offers well-established and significant benefits for infant health and development, as well as health benefits for women. Most breastfeeding research focuses on the early postpartum period, despite the WHO recommendations to continue breastfeeding for up to two years or longer. Inves
Objective To explore the effects of immediate parent–infant skin-to-skin contact (iSSC) at very preterm birth on maternal–infant behavioural responses and hypothalamic–pituitary–adrenal (HPA) axis reactivity to age-appropriate socio-emotional stress at 4months corrected age. Design Two secondary outcomes from a multicentre randomised controlled trial with two non-blinded parallel groups. Setting T
HVAC systems have the purpose of improving indoor air quality in buildings to enhance appropriate occupants- comfort, health and good productivity. Window airing may be one measure to consider in the absence of occupant control of the ventilation and by that, we mean occupants opening windows and doors. Approximating the volume of air exchanged during window airing is important in understanding th
Background: Intracerebral hemorrhage (ICH) survivors are at increased risk of major adverse cardiovascular and cerebrovascular events (MACE) compared with population controls; however, little is known about the annual rates and risk factors for MACE. Methods: We searched Medline, Embase, and trial registries systematically in April 2024 for studies of adults with ICH, reporting either a MACE compo
Animals align their body in relation to different environmental cues, including spontaneous directional responses relative to the geomagnetic field known as magnetic body alignment. The biological significance of this behavior, however, remains undetermined for most taxa. In previous studies, migratory songbirds aligned their body with the cardinal directions of the geomagnetic field and their mig
The construction industry is a major contributor to resource consumption and waste generation in the EU, making the transition to circular construction essential. Reuse of building products is an important circular strategy, but large-scale implementation is hindered by limited market maturity and uncertainty regarding product availability. This study aims to investigate the gap between reported a
The energy system is undergoing significant changes and is expected to continue to evolve. Energy demand is anticipated to increase, as is renewable energy capacity, and technical solutions are advancing. For electrical power, traditionally centralized production is increasingly complemented by distributed production, transforming fundamental system functionality. These developing factors will aff
Recent decades have seen rapid development of energy-efficient technologies and designs.However, despite significant effort to ensure that new technologies meet energy-efficiency criteria, thereare discrepancies between predicted and actual energy use. To bridge this gap, it is important that suchtechnologies and designs align with users’ experiences and behaviours. This Ph.D. thesis aims to castl
The aim of this dissertation is to map out and illustrate particularly troublesome and central areas in grammar learning. The point of departure is Josefsson and Lundin’s three suggested threshold concepts within grammar: to be able to distinguish between meaning, form and function, to be able to distinguish between a linear and a hierarchical dimension and to be able to identify and segment claus
The pathogenic mechanisms leading to neurodegeneration in Huntington disease (HD) are not fully understood but involve accumulation of toxic mRNA and protein products in the brain. Recent studies described an unconventional autophagic pathway involving DNA and RNA degradation through DNautophagy and RNautophagy that is regulated by the lysosomal protein SID1 transmembrane family member 2 (SIDT2).
Context. While the influence of the LMC on Milky Way (MW) stellar streams has been extensively studied, streams associated with the Clouds have received far less attention. Beyond the Magellanic Stream, only four stream candidates (S1–S4) have been reported. Aims. We focus on the S3 stream, a long (~30°) and narrow (~1.2°) structure at 60–80 kpc that is nearly aligned with the LMC. Our goals are:
Group A Streptococcus (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interventions represent a promising but underexplored strategy. Historically, the streptococca
Ordered assemblies of colloidal semiconductor nanocrystals have traditionally been studied for energy transfer and electronic transport arising from wavefunction overlap between neighboring nanocrystals. In this perspective, we instead focus on light-coupled nanocrystal solids engineered primarily for light emission. These materials include ordered superlattices and compositionally doped assemblie
