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Objectives: Total body irradiation (TBI) is commonly used prior to hematopoietic stem cell transplantation (HSCT) in myeloablative conditioning regimens. However, TBI may be replaced by total marrow irradiation (TMI) at centres with access to Helical TomoTherapy, a modality that has the advantage of delivering intensity-modulated radiotherapy to long targets such as the entire bone marrow compartm
Objective: The aim of this integrative review was to identify facilitators and barriers to patients’ well-being when being cared for in an ICU setting, from the perspective of the patients. Background: To become critically ill and hospitalised in an ICU is a stressful, chaotic event due to the life-threatening condition itself, as well as therapeutic treatments and the environment. A growing body
Background: Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range of cardiovascular conditions, such as atrial fibrillation, stroke, and diastolic dysfunction. LA segmentations are currently being performed manually, which is time-consuming and observer-dependent. Methods: This study presents an automated imag
The cloud control systems (CCs) are inseparable parts of industry 4.0. The cloud, by providing storage and computing resources, allows the controllers to evaluate complex problems that are too computationally demanding to perform locally. However, connecting physical systems to the cloud through the network can provide an entry point for attackers to infiltrate the system and cause damage with pot
Nature-based solutions (NBS), understood as actions that use ecosystem processes to address societal needs, can play important roles to future-proof river landscape development for people and nature. However, knowledge gaps exist how NBS can be planned and implemented at landscape scales. This Special Issue brings together insights and experiences from studies of assessing, planning, and implement
Recurrent self-fertilization is thought to lead to reduced adaptive potential by decreasing the genetic diversity of populations, thus leading selfing lineages down an evolutionary “blind alley.” Although well supported theoretically, empirical support for reduced adaptability in selfing species is limited. One limitation of classical theoretical models is that they assume pure additivity of the f
The assassination of Iranian top nuclear scientist Mohsen Fakhrizadeh is one of numerous assassinations in Iran conducted by foreign powers ever since 2007. In the past six months, assassins have in addition to Fakhrizadeh also been able to kill Al-Qaida’s no. 2 on Iranian soil. The three most important organizations in the Iranian intelligence community are the Ministry of Intelligence, as well a
Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently, diphosphatase NUDT15 was linked to thiopurine metabolism with NUDT15 polymorphism associated with drug toxicity in patients. Profiling NNA drugs, we identify acyclovir (ACV) and ganciclovir (GCV) as two new NNAs metabo
In this concluding commentary, the overall theme of the special issue as well as the collective contribution of the individual articles are addressed and elaborated upon. In particular, it focuses on the manifold commonalities that exist between South Asian states—both in terms of shared traits or dynamics and the recurrent attribution of negative connotations to neighboring states—and how these i
Transfusion of ABO major incompatible platelets (where the recipient has antibodies against the ABO group of the transfused platelets) has been shown to be associated with lower platelet count increments following transfusion [1], although this does not appear to translate to a difference in bleeding outcomes [2]. Transfusion of minor ABO incompatible platelets (where the suspending plasma of the
Detta är slutrapportering av rektorsuppdraget Samordning av universitetets hantering av forskningsdata, Dnr STYR 2019/295. Rapporten beskriver forskningsdataområdets disruptiva natur och dess relation till e-infrastrukturområdet, hur ett samordningsuppdrag formaliserades och med tiden formerades, vilka underprojekt som initierats och delområden som bevakats, föreslår en färdplan inför nästa steg i
Projektet har gjort en kartläggning över Lunds universitets förmågor att stötta god forskningsdatahantering med hjälp av verksamhetsarkitekturella metoder. Kartläggningen grundar sig på intervjuermed forskare, workshops med forskare, intervjuer med expertroller och stödorganisationspersonal,samt enkät till stödorganisationer. Analyser av insamlat material har resulterat i grafiska representationer
In this paper, I analyse developments in the relationship between popular musicians and their audiences that have intensified during the COVID-19 pandemic of 2020–21. The first, guilty geographies, concerns musicians and music venues becoming increasingly reliant on charitable audience support, appealing to fans’ ethical consciences through the crowdfunding (or fan-funding) model. The second, comp
Purpose: Off-target binding in the skull and meninges is observed in some subjects undergoing tau positron emission tomography (PET) and could potentially differ between men and women. In this study we elucidate sex differences in tau off-target binding using three different tau PET tracers. Methods: 541 cognitively unimpaired amyloid-β negative participants underwent tau PET using [18F]flortaucip
Petroleum, contains proportions of contaminants such as sulfur, nitrogen, oxygen, and metals, such as nickel, iron, copper, sodium, and vanadium. Particularly, contaminants containing sulfur cause problems during handling, transportation, and the use of the their derivatives. This work had the goal of cracking the heavy crude oil molecules by reacting these molecules with tetralin and simultaneous
In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yi
