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To predict the vibroacoustic performance of complex thin-walled structures, an analysis using a finite element model considering structure–acoustic interaction is often required. The acoustic response of such models can be time-consuming to compute and sensitive to minor design changes. These models can be too computationally intense since fast design optimizations must be performed. Moreover, kno

Background Recently, a group of betainized compounds have been suggested to play a role in health effects in relation to a whole-grain-rich diet. Objectives The aims of this study were to develop a quantitative mass spectrometric method for selected betainized compounds in human plasma, and to investigate their association with nutrient intake and measures of metabolic health in participants of

A Circular Economy (CE) can help to achieve the sustainable development goal of responsible consumption and production. Product policies, in turn, can support CE objectives by promoting reuse of products, recycling of materials, and providing ecodesign incentives for more durable products. This thesis examined the role of product policies in meeting CE objectives in the EU, with specific focus on

Economic globalization and the modularization of value chains increasingly challenge long-held conceptual models explaining the spatial evolution of industries. This paper seeks to re-interpret early industry life cycle dynamics by disintegrating an industry's value chain into upstream, core and downstream parts and characterizing each part according to its underlying global innovation system (GIS

BackgroundThe incidence of human papilloma virus (HPV)-related oral cancer has recently increased worldwide. The role of dentists is of prime importance in the early detection of oral cancer which would result in a favourable outcome for the patients. The aim of the current study was to assess the knowledge, awareness and attitudes of dental students, interns and postgraduate maxillofacial residen

This article draws attention to storytelling in public diplomacy. Based on interviews with officials in the European External Action Service (EEAS) and a campaign on social media, it explores storytelling in EU public diplomacy. It treats storytell-ing as narrative strategies that tap into the power of dramaturgy and visual elements to mediate emotions and identity in international politics. This

Large-scale land acquisitions are a critical driver of global socio-environmental change, in particular in the Global South. This study aims to investigate drivers, impacts and feedbacks of environmental change in Kilombero Valley, Tanzania, a region in rapid societal and environmental transformation. We use land cover classifications to map and quantify land cover changes from 1990 to 2016, and c

Background: Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstruction leading to higher image contrast compared to conventional reconstruction algorithms, while also limiting noise. The noise penalization factor β controls the trade-off between n

Background: The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and

This pilot study uses a Landau-Lifshitz phase field model to study the growth of a precipitate originating from a crack tip. A boundary layer giving a remote square root singular elastic stress field is applied. The materials are assumed to be elastic-plastic with linear strain hardening. The precipitate is assumed to expand in a simplified anisotropic manner, meaning that the hydride is assumed t

CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking. In this study we investigated the effect of CD47-deficiency on atherosclerosis using a model of adeno-associated virus (AAV)-induced hypercholesterolemia. We observed increased plaque formation in CD47 null mice compar

Purpose: After resuscitation from out-of-hospital cardiac arrest (OHCA), renal injury and hemodynamic instability are common. We aimed to assess the association between low cardiac output during targeted temperature management (TTM) and acute kidney injury (AKI) after OHCA. Materials and methods: Single-center substudy of 171 patients included in the prospective, randomized TTM-trial. Hemodynamic

DNA methylation contributes to the maintenance of genomic integrity in somatic cells, in part through the silencing of transposable elements. In this study, we use CRISPR-Cas9 technology to delete DNMT1, the DNA methyltransferase key for DNA methylation maintenance, in human neural progenitor cells (hNPCs). We observe that inactivation of DNMT1 in hNPCs results in viable, proliferating cells despi

Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To better understand the genomic landscape of mucosal melanoma, here we describe whole genome sequencing analysis of 67 tumors and validation of driver gene mutations by exome sequencing of 45 tumors. Tumors have a low point mutation burden and

Neuroanatomy suggests that adjacent neocortical neurons share a similar set of afferent synaptic inputs, as opposed to neurons localized to different areas of the neocortex. In the present study, we made simultaneous single-electrode patch clamp recordings from two or three adjacent neurons in the primary somatosensory cortex (S1) of the ketamine-xylazine anesthetized rat in vivo to study the corr

Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trai