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Positional cloning of susceptibility genes in complex diseases like rheumatoid arthritis in humans is hampered by aspects like genetic heterogeneity and environmental variations, while genetic studies in animal models contain several advantages. With animal models, the environment can be controlled, the genetic complexity of the disease is minimized and the disease onset can be predicted, which si

The purpose of this study was to determine why apparently homogeneous IgG antibodies were, in some cases, fractionated into at least two components by liquid-liquid partition chromatography (LLPC) in an aqueous two-phase system. Four mouse monoclonal IgG antibodies, two against albumin, one against IgG and one against thyroxine, were shown to adopt different conformational isomeric forms. The four

The high fat-fed mouse is an experimental model for studies of islet dysfunction as a mechanism for glucose intolerance and for evaluation of therapeutic targets. This model is, however, dynamic with a temporal and dietary fat content-dependent impact on islet function and glucose tolerance, the details of which are unknown. This study therefore examined the time course of changes in the insulin r

Renässansens Florens, sekelskiftets Wien, industrialismens Manchester och mellankrigstidens Paris. Enstaka företag och vissa universitetsmiljöer vid Cambridge och Stanford. Förnyelsen inom konst, arkitektur, musik, litteratur, teknik och vetenskap har sina geografiska och institutionella fästen. Med stor kunskap visar författaren vad som är utmärkande för dessa och andra kreativitetens miljöer. De

Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and

Popular Abstract in Swedish Chefskap och ledarskap hos sjuksköterskor i högre chefsbefattningar inom hälso- och sjukvården. I dagens hälso- och sjukvård har sjuksköterskor i chefsposition en förändrad och utökad roll, bland annat till följd av decentraliserade organisationer och utökade ansvarsområden. Utvecklingen av omvårdnaden kommer till en del att vara beroende av chefernas förmåga och skickThe aim of this thesis was to illuminate the management and leadership of nurse managers within Swedish health care organizations and to recognize influencing factors of importance for the nurse managers in exercising and developing their management. The interviewees were all active in their positions at the time of the interviews. The nurse managers served at top management levels in either execu

A portable nerve conduction testing device was compared with a conventional method of measuring median nerve distal latencies. In a population-based study, a health questionnaire was mailed to a random sample of 3000 participants (aged 25 to 74 years). Two hundred and sixty-two responders with numbness and/or tingling in the median nerve distribution, and 125 asymptomatic responders underwent clin

1. Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca2+-induced exocytosis in single insulin-secreting mouse pancreatic B-cells. 2. ACh (250 microM) increased exocytotic responses elicited by voltage-clamp depolarizations 2.3-fold. This effect was mediated by activation of muscarinic receptors and dependent on elevation of the cytopl

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The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6-/- mice did not, however, suffer spontaneous bleeding and had normal blee

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Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. We show that overexpression of PKCd or PKCq renders SK-N-BE(2) neuroblastoma cells sen

The objective of this thesis is to numerically simulate a fluid jet injected into a crossflow of the same or another fluid, respectively. Such flows are encountered in many engineering applications in which cooling or mixing plays an important role, e.g. gas turbine combustors. The jet in crossflow (JICF) is used both for cooling and for injecting liquid fuel into the air stream prior to combustio

Discussions about values are common in many contexts. Often, what is debated is the choice of means to realize or protect various values, but sometimes the discussion concerns the very values that ought to be realized or protected. Philosophical debate in this area has mainly been focused on two kinds of issues. Philosophers have tried to identify the set of fundamental values, i.e., to provide wh

Quality of movement assessment using the Body Awareness Scale–Health (BAS-H) was validated against the following self-rating tests: Nottingham Health Profile (NHP); Arthritis Self-Efficacy Scale (ASES); Psychological General Well-Being (PGWB); Sense of Coherence (SoC); Sivic Psychosomatism test (SPS); Symptom Check List 90-R (SCL 90-R); and Visual Analogue Scale for pain intensity (VAS-pain). In t

An important signal involved in glucose-stimulated insulin secretion is transduced through the action of a lysosomal acid, glucan 1,4-alpha-glucosidase. We investigated the Ca2+ dependency of this enzyme activity in relation to insulin release. In isolated islets, increased levels of extracellular Ca2+ induced a large increase in acid glucan 1,4-alpha-glucosidase activity accompanied by a similar