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This article analyses the ethical and philosophical dimensions of preimplantation genetic diagnosis for creating saviour siblings. It evaluates the moral concerns of autonomy and instrumentalisation, while situating the debate within broader legal and philosophical frameworks of reproductive decision-making.
BACKGROUND: A history of hypertensive disorders of pregnancy is associated with at least twice the risk of incident ischemic heart disease. Whether the long-term outcome following treatment with coronary artery stenting is associated to the history of hypertensive disorders of pregnancy is unknown. METHODS AND RESULTS: We included 8364 women (age ≤65 years) undergoing first coronary artery stentin
Logs are prevalent in modern cloud systems and serve as a valuable source of information for system maintenance. Over the years, many supervised, semi-supervised, and unsupervised log analysis methods have been proposed to detect system anomalies. In particular, semi-supervised methods have garnered increasing attention as they balance reduced labeled data requirements and optimal detection perfor
Principal component analysis (PCA) and k-nearest neighbor (kNN) can be applied to extract and compare activity distributions from electrocorticogram (ECoG) signals across recorded neural activity. Here, we present a protocol for recording ECoG activity from the neocortex of rats and applying PCA and kNN on the recorded data. This protocol allows for comparison between different types of cortical a
Studies on cortical function have been a cornerstone in research trying to understand our brains for a long time. For many years now a basic feature of cortical processing has been the idea of a functional localization, with different areas or even neurons in the cortex having clear, individual, functions. This idea has been challenged from the outset, and with new methods to study the cortex the
BACKGROUND: Oesophagectomy, a corner stone in curative treatment of oesophageal cancer, is a complex procedure with high complication rates. Postoperative gastric tube decompression is debated and some centres are abandoning routine nasogastric (NG) tube use. We hypothesised that postoperative NG tube removal is non-inferior to five days of NG tube decompression, with regard to the risk of anastom
Antibody–enzyme complexes (AECs) are ideal molecular recognition elements for im-munosensing applications. One molecule possesses both a binding ability to specific targets and catalytic activity to gain signals, particularly oxidoreductases, which can be integrated into rapid and sensitive electrochemical measurements. The development of AECs using fragment antibodies rather than intact antibodie
BACKGROUND: Omentectomy has traditionally been performed in gastric cancer surgery, but omental preservation has become increasingly common. It is unclear whether omentectomy leads to additional survival benefit compared with omental preservation. This nationwide population-based cohort study aimed to assess survival and surgical outcomes comparing omental preservation to omentectomy in curative-i
Antibody–enzyme complexes (AECs) are ideal for immunosensing. Although AECs using antibody fragments can be produced by bacterial hosts, their low affinity limits their sensing applications. We have improved the affinity of AECs by combining two antibodies using Catcher/Tag systems; however, it requires multiple antibodies and an enzyme production process. In this study, to realize the production
One challenge in the continuous monitoring of insulin lies with the unavailability of a high-affinity biological recognition element (BRE) with kinetic parameters sufficient to track fluctuating concentrations of insulin in vivo. An approach to overcome this limitation is to engineer a high-affinity BRE to selectively modulate its binding kinetics in response to an external signal. Herein, we desi
This article presents an innovative participatory approach to the ethical aspects of conducting body mapping research. Drawing from experiences from an earlier project with digital sex workers, we examine how body mapping, when integrated with what we term “embodied oscillative ethics,” creates opportunities for meaningful collaboration and knowledge co-creation while addressing complex ethical ch
PurposeTo investigate long-term effects of intravitreal injections on visual outcome, retinal function and structure in eyes with central retinal vein occlusion (CRVO eyes) and macular oedema and compare with untreated CRVO eyes to determine the long-term effects of anti-vascular endothelial growth factor on photoreceptor cell function.MethodsA retrospective study of 38 eyes from 38 CRVO patients.
This study examines shifts in Swedish media representations of refugees over three decades by analyzing coverage of refugees from Yugoslavia (1992), Syria (2015), and Ukraine (2022) in the newspaper Dagens Nyheter. Through frame analysis, the research reveals how media narratives reconcile Sweden’s humanitarian self-image with increasingly restrictive refugee policies. While institutional responsi
This paper deals with numerical investigations of cross laminated timber (CLT) beams. Previous investigations have revealed discrepancies between experimental test results and suggested design methods regarding shear force capacity of such beams. To gain further understanding of the failure behaviour and the shear force capacity, nonlinear finite element analyses have been performed, using a cohes
Between 2014 and 2022, Sweden introduced a feminist foreign policy (FFP), which entailed a “systematic gender equality perspective throughout foreign policy”. This chapter focuses on how FFP was practiced and implemented by officials at Swedish Embassies around the world. Using a framework of practice theory, implementation theory and feminist institutionalism, the overarching questions guiding th
Corruption is one of the most pressing and systemic issues of the 21st century,significantly hindering sustainable socio-economic development acrossnations. It undermines trust in authorities and legal institutions, which inturn diminishes investment activities, restricts entrepreneurial growth, andexacerbates social inequality. Kazakhstan, as a country actively working tomodernize public administ
Study region: The Brazilian wooded Cerrado biome is a tropical savanna, over 50 % of which has been converted to agricultural land. Study focus: We evaluated changes in water balance variables (surface flux, evaporation, soil-water storage, infiltration, groundwater recharge, and root uptake) due to climate change. The study included (i) calibration and validation of the Hydrus model through obser
Syftet med artikeln är att bidra med ny kunskap om hur en lektionsdesign, som tar utgångspunkt i litterära aspekter, kan möjliggöra utveckling av elevers läsförståelse i åk 4. En learning study med utgångspunkt i de litterära aspekterna: karaktärsbeskrivning, miljöbeskrivning, handling och tema genomfördes i tre klasser i årskurs 4 med 60 elever och tre lärare. Det empiriska materialet består av tThe article aims to provide new knowledge regarding how a teaching design, based on literary concepts, makes possible a deeper development of pupils’ reading comprehension in grade 4. A Learning study focusing on the literary concepts: character, setting, plot and themes was conducted in three classes in year 4 with 60 participating pupils and three participating teachers. The empi-rical material
The Gulf Cooperation Council (GCC) countries have experienced significant migration trends in recent decades, with a heavy reliance on foreign labour, particularly from Southern Asia. As of 2024, the GCC hosts 25 million migrants, with Southern Asians constituting a significant proportion. This demographic reality has shaped the region's socio-economic structure, with expatriates dominating the pr
