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Variation at the 17q21.31 locus, which contains the gene encoding microtubule-associated protein tau (MAPT), has been associated with neurodegenerative disorders, including Parkinson’s disease (PD). This highly complex locus is characterized by two broadly defined haplotypes: H1 and the inverted H2 haplotype. While H1 has been associated with an increased PD risk and is present in all ancestry pop
A prototype of a novel Photoemission Mask type X-ray Beam Position Monitor (PheM XBPM) for the ‘white’ undulator radiation which concept was proposed and has been built and tested. The prototype was designed and manufactured at MAX IV. Two PheM XBPMs were in-stalled at MAX IV 3 GeV storage ring at SoftiMAX and CoSAXS beamline frontends. Signal modelling, optimization and performance results of the
Purpose: Ovarian cancer is the most lethal gynecological malignancy, and chemotherapy strategies have evolved substantially over recent decades. This study aimed to evaluate whether survival outcomes of epithelial ovarian cancer (EOC) have improved over time and to explore trends in younger patients of reproductive age. Basic Procedures: We retrospectively analyzed real-world data from the Tokai O
Introduction: The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim: The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD. Results and Discussion: The topics covered both clinical aspects of management and biochemical and laboratory
Oral streptococci colonize the oral cavity in multispecies communities. They adhere to the salivary pellicle through surface interactions, whereafter additional bacteria and fungi are recruited to form the stable community. The oral streptococci reside as commensals in the oral cavity and contribute to homeostasis, for example, through colonization resistance. However, accumulation of bacteria at
RATIONALE: Information is missing on the tissue cell expression patterns of interleukin 33 (IL-33) and splice variants of the IL-33 receptor ST2 in normal and chronic obstructive pulmonary disease (COPD) lungs.OBJECTIVES: To characterize the expression patterns of IL-33, the soluble ST2 (sST2) and membrane-bound ST2 (ST2L) splice variants in the poorly studied small airway and distal lung compartm
We describe a case of allergic contact dermatitis (ACD) to Abilar (Repolar Pharmaceuticals Oy, Espoo, Finland), a wound ointment containing Picea abies (Norway spruce) resin with evidence suggesting primary sensitization.
The aim of this paper is to discuss the ethical and legal justification of the broadly accepted ethical principle that researchers may not include adults without decision-making capacity to consent to participating in research studies if there are potential research participants with capacity who could be included instead. From the perspective of disability rights, the paper argues that this ethic
To efficiently implement plasma and cerebrospinal fluid (CSF) biomarkers for staging and prognosis of Alzheimer disease (AD), we must understand their dynamics across disease progression. We analyzed participants from the Swedish BioFINDER-2 study with mass spectrometry measurements of plasma and CSF tau species, including eMTBR-tau243/MTBR-tau243 and phosphorylation occupancies (%p-tau). Disease
Pain avoidant behavior is a predictive factor for reduced function in children with persistent pain. A model to explain this is the Fear-Avoidance Model of Pain (FAM). In FAM pain-related fear plays an important role in the development and maintenance of avoidant behavior. The Fear of Pain Questionnaire-Child Report Short Form (FOPQC-SF) was developed to assess pain-related fear in children 8 to 1
OBJECTIVES: To investigate the progression of radiographic damage in hands and feet of patients with early rheumatoid arthritis monitored prospectively for 15 years, and to search for predictors.METHODS: This study comprises 990 patients from the BARFOT cohort, included 1992-2006. Radiographs of the hands and feet were performed over time and evaluated by the Sharp van der Heijde scoring (SHS) met
BACKGROUND: Turning performance is an important and challenging motor activity, with potential relevance in several brain diseases. This study aimed to determine how Alzheimer's and vascular pathologies are associated with turning (360° while standing and 180° while walking), both as a single task and during dual-tasking in cognitively healthy older people.METHODS: Cognitively healthy older people
BACKGROUND: Obesity assessed at a single time point in adulthood has shown no consistent association with prostate cancer (PCa) incidence but has been positively associated with PCa death. We investigated the association of total and age-specific adult weight trajectories with PCa aggressiveness and death.METHODS: We analyzed data from 258,494 men in Sweden with at least 3 weight observations betw
BACKGROUND: Almost a decade ago, about half of biomedical PhD programs across Europe specifically stated that systematic reviews could not be accepted as part of a doctoral thesis, illustrating limited merit value at that time. The aim of this study was to explore current Swedish university policies on this research design.METHODS: Policy documents for PhD theses and applications to associate prof
Poikilosis is a recently introduced unifying theory in biology. It is based on the pervasive heterogeneity of all biological molecules, complexes, systems, networks, cells, organisms, and others. In a relaxed situation, such entities, called levels, are in an energetically favorable state called lagom. These states are maintained actively and passively by TARAR (tolerance, avoidance, repair, atten
INTRODUCTION: Knowledge about the quantity, delivery and setting of rehabilitation after stroke in clinical practice is sparse. We investigated the utilisation of rehabilitation services in a regional cohort up to 2 years after stroke.PATIENTS AND METHODS: Data on people living in ordinary housing in southern Sweden with a first-ever stroke during 2016-2017 were collected from the Swedish Stroke R
BACKGROUND: Key tasks in the development of guideline recommendations include determining the magnitude of desirable and undesirable health effects, the overall net effect and assessing the certainty of evidence. Developing and using decision thresholds can support these tasks and increase transparency, however evidence of the procedural steps is limited. We describe a systematic, step-by-step app
BACKGROUND AND OBJECTIVES: Health guidelines play a central role in informing clinical practice, public health measures and health policy. But their trustworthiness may be undermined by factors such as insufficient methodological rigor, lack of transparency, conflicts of interest, and inconsistent application of established standards. Existing appraisal tools address selected aspects of guideline
