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There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by β-amyloid (βA) accumulation, neuroinflammation, excessive synaptic pruning, and cognitive decline. Despite extensive research, effective treatments remain elusive. Here, we identify potassium channel-interacting protein 3 (KChIP3) as a key driver of AD pathology using the 5XFAD mouse model. KChIP3 levels were significan
Att placeras på HVB är en av de mest ingripande insatserna inom socialt arbete. För ungdomar innebär den ofta att tillvaron blir präglad av förändring och en känsla av att framtiden är osäker. Licentiatuppsatsen fördjupar kunskapen kring existentiella utmaningar som kan uppstå i denna process. Studien har en teoretisk utgångspunkt i existentiell filosofi och fokuserar på hur grundläggande livsvillWhen young people are placed in residential care (HVB) it is one of the mostfar-reaching interventions in social work, often involving significantdisruptions to their everyday lives, future outlook, and sense of self. Whilesuch placements frequently raise questions about meaning and freedom thesechallenges remain largely unexplored from an existential perspective in bothresearch and practice. This
The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutro
This qualitative study explores the existential dimensions of youths’ lived experiences in residential care through an existential – phenomenological approach. Based on in-depth interviews and participant observations with 16 youths in Swedish residential care, the study investigates how young people navigate existential concerns such as freedom, anxiety, and meaning within an institutional contex
Resource provisioning for applications hosted in the cloud is a difficult task due to inherent performance variability in the infrastructure. Control theory has proven to be an efficient tool to increase the predictability of cloud applications. However, a prerequisite for a successful control design is an adequate model of the involved dynamics. In this paper we focus on modeling of controlled se
An activated catalyst prepared from a mixture of nickel nitrate hexahydrate with zinc in dry ethanol under reflux showed exceptional catalytic activity for the reduction of nitroarenes to the corresponding azoxy compounds exclusively in the presence of hydrazine monohydrate. However, when nickel nitrate hexahydrate was replaced by nickel chloride dihydrate with zinc, only the aminoarenes were form
Abstract: For patients with locally advanced head and neck tumours or other defects, the preferred curative treatment is extensive reconstructive surgery using free microvascular flap(s), oftentimes followed by postoperative radiotherapy. The procedure offers superior functional and aesthetic advantages, but the treatment course is long and complex and burdened with a significant risk of complicat
This study explores a novel approach to utilizing waste biomass for syngas production, with the potential for carbon sequestration. An integrated biomass conversion process combining pyrolysis, CO2 reforming, and MILD combustion is proposed. In the proposed system, the bio-oil obtained from pyrolysis can be used in a reforming step, converting it into syngas with a suitable H2/CO ratio for chemica
Arabinoxylan (AX) with varying arabinose to xylose (A/X) ratios of 0.85, 0.57 and 0.39 was extracted from wheat bran, and the conformations of the AX polysaccharides dispersed in water were investigated using small-angle X-ray scattering. The persistence length (Lp) and the conformation statistics (expressed by the Flory exponent v or the mass fractal) of the AX varied with their A/X ratios. The L
A study of 25 pupils working in groups with a digital mathematics game on table tabletswas conducted in a Swedish first school year class. The pupils’ communications and actions whensolving problems, with no teacher interference, were studied to contribute knowledge about howgroups of pupils engage in digital games. Data sets, in the form of transcripts from video recordings ofpupils working in gr
Vårt team av kliniska forskare i Lund, Sverige, fann att elektromagnetisk strålning, som den som används i mobil kommunikation, även vid låga effektvärden, gör att användarnas blodalbumin läcker genom blod-hjärnbarriären "BBB" in i hjärnvävnaden .BBB är tänkt att skydda hjärnan mot oönskade och giftiga molekyler som potentiellt finns i blodet för att överföras till hjärnvävnaden. Men vårt team i L
This paper aims at formulating and analysing the development of 15 students in their creations of mental representations of limits of functions during a basic mathematics course at a Swedish university. Their concept images are sought via questionnaires and interviews. How do students respond to limits of functions? The data indicate that some students have incoherent representations, but they do
The main aim of this article is to discuss the attitudes to mathematics of students taking a basic mathematics course at a Swedish university, and to explore possible links between how well such students manage to solve tasks about limits of functions and their attitudes. Two groups, each of about a hundred students, were investigated using questionnaires, field notes and interviews. From the resu
Students at a Swedish university were subjects in a study about learning limits of functions. The students' perceptions were investigated in terms of traces of concept images through interviews and problem solving. The results imply that most students' foundations were not sufficiently strong for them to understand the concept of limit well enough to be able to form coherent concept images. The tr
