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FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how
Consider nonbacktracking convolutional decoders that keep a fixed number of trellis survivors. It is shown that the error performance of these depends on the early part of the distance profile and on the number of survivors kept, and not on the free distance or the details of the code generators. Particularly, the encoder may be feedforward systematic without loss. Furthermore, this kind of encode
The natural frequencies or the singularity expansion method (SEM) poles are computed for circular disks. We treat the acoustically soft disk, i.e, the Dirichlet boundary condition, and the perfectly conducting disk. The poles are found by an application of theT-matrix method by searching the zeros of a determinant. The poles associated with the first values of the azimuthal indexmare shown in both
OBJECTIVE: To study the information gained by extending a well-established instrument of dependence/independence in activities of daily living with a self-rating of difficulty, and to illustrate the relevance and usefulness of this combined approach with cross-national data. DESIGN AND SUBJECTS: Cross-sectional survey study data collected with 1918 very old persons in 5 European countries. METHODS
The press-fit condylar (PFC) cruciate-retaining total knee prosthesis is well documented in the literature. In 1997, a modification of the femoral component was introduced, and the prosthesis was renamed PFC-Sigma. The alteration may influence the migratory and rotational pattern of the tibial component and thus long-time survival rate. In this radiostereometric analysis, we found that the micromo
Image processing is an area with many computationally demanding algorithms. When implementing an algorithm the programmer has to make the choice of either using a high-level language, thereby gaining rapid development at the expense of run-time performance. Or, using a lower-level language having higher runtime performance, but also a higher implementation cost. In this paper we present PyGPU, an
In order to identify the protein responsible for a dopamine peroxidizing activity, previously described in human normal and parkinsonian substantia nigra by our group, we developed non-denaturing polyacrylamide gel electrophoresis conditions, mimicking the characteristic colour in vitro reaction, resulting from cyclic oxidation of dopamine (DA). After separating protein mixtures from human normal
This artcile analyzes the role of the media in the public sphere of Sweden as the political landscape in the past decade or so has evolved from the traditonal social democratic model to a more neo-liberal one.
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Premature prelabor rupture of the fetal membranes affects about 3% of pregnancies. The cause is usually infection, especially at earlier gestations. The prognosis and the risks of delivery are both much worse at earlier gestations. Before viable pregnancy, termination may be offered. Once the fetus is viable, steroids to mature the fetal lungs and antibiotics to reduce infection are the mainstays
Hormone-sensitive lipase (EC 3.1.1.79; HSL) is a key enzyme in the mobilization of fatty acids from stored triacylglycerols. HSL activity is controlled by phosphorylation of at least four serines. In rat HSL, Ser563, Ser659 and Ser660 are phosphorylated by protein kinase A (PKA) in vitro as well as in vivo, and Ser660 and Ser659 have been shown to be the activity-controlling sites in vitro. The ex
