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Background: Unexpected prolongation of first-line coagulation tests, including activated partial thromboplastin time (APTT), should trigger further work-up by performing mixing tests to elucidate the underlying cause, direct further specific testing and clarify their possible clinical impact. The aim of our study was to assess whether methodological diversity has any impact on the APTT mixing test
Background: Providing evidence-based interpretative comments (IC) is an integral task of clinical laboratory professionals. It may be of special relevance for coagulation testing, where pathological first-line tests could trigger more specialized tests. Our aim was to evaluate the quality of ICs provided to the physician in two samples with activated partial thromboplastin time (APTT) prolongation
In healthy individuals, a delicate balance between pro- and anticoagulant systems ensures efficient hemostasis and an open vascular system. As sites of vascular damage, a series of procoagulant reactions take place, which are carefully controlled by several anticoagulant proteins. Circumstantial and genetic risk factors increase the risk of venous thrombosis. Circumstantial risk factors are usuall
Carbohydrates constitute an enormous diversity of molecules, from simple monosaccharides to highly complex branched heteropolymers of molecular weights that are challenging to determine. Carbohydrates are molecules with essential biological functions, including energetic metabolism, cell recognition, structure, and protection. This chapter integrates three aspects associated with the analysis of b
The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies3–7, large-scale genome-wide association studies (GWAS) of fasting BCF8,9 or functional islet studies on T2D risk variants10–14. Nonetheless, GWAS focused on BCF traits derived from oral
In five sentence continuation studies we investigated how different forms of negation (negative quantifier, clausal negation, lexical negation) impact discourse structure in Swedish. We looked at what set of referents (the reference set for which some property holds, or the complement set, for which the property does not hold) speakers considered most noteworthy (speaker salient), and what form th
This Regional Outlook focuses on the 2024 Jordanian parliamentary elections, their political consequences, and how the elections were affected by the War on Gaza.
This chapter analyzes the UNHCR Refugee Zakat Fund and the use of Islamic Social Welfare Instruments as a tool for supporting the refugee issue. Looking at the Refugee Zakat Fund from a legal and practical perspective, the research will try to understand the experience of this international non-Muslim organization in managing religious funds for Muslim refugees. The study will address the followin
BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and related conditions. In previous registry-based, retrospective studies, autoimmune diseases have been associated with MGUS. However, these studies were not based on a screened population and are therefore prone to ascertainment bias.OBJECTIVE: To examine whether MGUS is associated with
BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic precursor conditions to multiple myeloma and related disorders. Smoldering multiple myeloma is distinguished from MGUS by 10% or greater bone marrow plasma cells (BMPC) on sampling, has a higher risk for progression, and requires specialist management.OBJECTIVE: To develop a
