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Radiological and pathological characteristics of hip osteoarthritis (OA) is joint-space loss due to degradation of articular cartilage. However, patients with early-stage OA do not yet show any radiological signs, which leaves them without diagnosis and treatment. This study evaluates the potential of a novel tool to identify pre-radiographic OA changes based on hip bone morphology. Two statistica

This paper focuses on the spatial distribution of bone tool production waste from two Mesolithic sites in Sweden, Ringsjöholm and Strandvägen, with well-preserved faunal remains including bone and antler artifacts. Local production on both sites has generated a variety of identifiable waste products deriving from complete chains of production, including unmodified bones, debitage and finished prod

In order to achieve a consistent level of failure probability, structural design codes are optimized using probabilistic methods. This optimization process traditionally focuses on the ultimate limit states (ULS). However, in the design of timber structures the performance of the structural members is often governed by the serviceability limit state (SLS) associated with different load levels than

Introduction: Occupational balance is the experience of having the right amount and right variation between work, domestic work, leisure, rest, and sleep. There is limited knowledge about which factors predict parents’ combined occupational balance, and if the combined occupational balance is associated with work and life satisfaction. Aim: The first aim was to explore whether domestic work and ch

A common assumption in product value literature is that authenticity is what contemporary consumers value the most. However, as this paper illustrates, the meaning of authenticity is unclear, and the term appears foreign to product development practitioners. The purpose of this paper is to explore in what ways product development professionals talk about product value in general and how this relat

The present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and GregorThe present research investigates the formative processes of international criminal law through the iterative citation of judicial decisions in adjudicatory practices. Given the centrality of the judge in the adjudication of international criminal law, this study is underpinned by a legal realist approach to international law informed by the work of Alf Ross (Scandinavian Legal Realism) and Gregor

The production and consumption of fossil fuels need to decrease significantly to meet the 2015 Paris Agreement's ambitious climate change goals. However, fossil fuels continue to receive significant amounts of government support. Although reforming fossil fuel subsidies can yield climate change mitigation benefits, the specific international and domestic political context and political economy of

The international community has been engaged in capacity development for decades, sometimes under different names or with a slightly different focus. So far, these efforts have failed to bring significant and sustainable change. The Sendai Framework for Disaster Risk Reduction 2015–2030 specifies capacity development as the means to reduce disaster losses substantially. The purpose of this paper i

No drugs are currently approved that change the natural course of osteoarthritis (OA) and translate to long-term, clinically relevant benefits. Two-stage clinical trial designs for OA have now received FDA approval, but remaining challenges lie in defining suitable study populations, surrogate outcomes and pivotal long-term, clinically relevant trial endpoints.

We consider the Ginzburg–Landau functional, defined on a two-dimensional simply connected domain with smooth boundary, in the situation when the applied magnetic field is piecewise constant with a jump discontinuity along a smooth curve. In the regime of large Ginzburg–Landau parameter and strong magnetic field, we study the concentration of the minimizing configurations along this discontinuity b

The overall aim of this thesis is to gain a clearer picture of the differences in mobility among the young-old living in Sweden’s large metropolitan regions. This thesis comprises four papers. Paper I explores the inclusion of public transport as an element of mobility among the young-old living in the Stockholm region. Paper II presents an analysis of cycling among older people in the city of Mal

Användningen av plast kommer att fördubblas inom 20 år, enligt plastbranschen. Det handlar inte längre om att förbjuda sugrör eller plastkassar – det saknas en vision för hela plastanvändningen, skriver tre forskare i Lund

Bacteroides ovatus is a member of the human gut microbiota. The importance of this microbial consortium involves the degradation of complex dietary glycans mainly conferred by glycoside hydrolases. In this study we focus on one such catabolic glycoside hydrolase from B. ovatus. The enzyme, termed BoMan26A, is a β-mannanase that takes part in the hydrolytic degradation of galactomannans. The crysta

Neurotransmitter release is dependent on influx of Ca2+ through voltage-operated calcium channels (VOCCs). These channels may be divided into L, N, T and P subtypes. To investigate the subtypes of VOCC involved in transmitter release from adrenergic nerves in the isolated rabbit ear artery, the effects of some subtype selective VOCC antagonists were examined on contractile responses induced by ele

1. Vascular effects of substance P were studied in human isolated pial arteries removed from 14 patients undergoing cerebral cortical resection. 2. Substance P induced a concentration-dependent relaxation in the presence of indomethacin. No relaxation was seen in arteries where the endothelium had been removed. 3. N omega-nitro-L-arginine (L-NOARG, 0.3 mM) abolished the relaxation in arteries from

Purpose: To investigate the change in incidence of referred carpal tunnel syndrome (CTS) and carpal tunnel release (CTR) surgery over time and regional variations. Methods: From the nationwide patient registry, we identified all adult individuals who had received first-time CTS diagnosis (International Classification of Diseases, 10th Revision code G560) at secondary or tertiary level and first-ti

Background: Older people with intellectual disability have high multimorbidity and poor physical and mental health compared with the general population. Consequently, they have a greater need for health care. Hospital readmissions may be an indicator of the quality of health care. However, so far, only a few studies have investigated this outcome in populations of people with intellectual disabili

The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations asso

Rats and mice with unilateral damage to the nigrostriatal dopamine system-induced by neurotoxins, such as 6-hydroxydopamine, overexpression of α-synuclein, or injections of toxic synuclein protofibrils-are widely used as experimental models to mimic the loss of dopamine neurons seen in Parkinson's disease. The amphetamine rotation test is commonly used to monitor the extent of motor impairment ind