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BACKGROUND: In mitral valve dysfunction, noninvasive measurement of transmitral blood flow is an important clinical examination. Flow imaging of the mitral valve, however, is challenging, since it moves in and out of the image plane during the cardiac cycle.PURPOSE: To more accurately measure mitral flow, a slice-following MRI phase contrast sequence is proposed. This study aimed to implement such

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals,

A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual

Urban landscapes, structures and design features are associated with travel mode choice and have implications for sustainable living environments. The particular role of the built environment for children’s independent active mobility has received increasing attention in research and practice. However, the complexity of the transactions between person and environment needs to be understood with sp

Accurate prediction of ship speed for given engine power and encountering sea environments is one of the key factors for ship route planning to ensure expected time of arrivals (ETA). Traditional methods need first to compute a ship's total resistance based on theoretical calculations, which are often associated with large uncertainties. In this paper, two statistical approaches are investigated t

Covariance tapering is a popular approach for reducing the computational cost of spatial prediction and parameter estimation for Gaussian process models. However, tapering can have poor performance when the process is sampled at spatially irregular locations or when non-stationary covariance models are used. This work introduces an adaptive tapering method in order to improve the performance of ta

We consider the analysis of continuous repeated measurement outcomes that are collected longitudinally. A standard framework for analysing data of this kind is a linear Gaussian mixed effects model within which the outcome variable can be decomposed into fixed effects, time invariant and time‐varying random effects, and measurement noise. We develop methodology that, for the first time, allows any

Are there any constraints on the number of participants allowing viable conditions for collaborative learning at SI-sessions? The manuals give little or no guidance in this regard and there seems to be no consensus amongst practitioners. In the literature, furthermore, the number of participants at typical SI-sessions is very rarely reported. As SI-leaders often are paid and good candidates may be

In the last few decades, sustainability science has developed into a formidable field of interdisciplinary scholarship aimed broadly at contributing to the global sustainability agenda. As a problem-driven science, sustainability science is necessarily interdisciplinary, though the field’s practitioners generally lack an explicit justification for the procedure of interdisciplinary research perfor

När det gäller klimatrörelsen och debatten kring den behövs kunskap om hur samhället fungerar. Det skriver sex forskare vid Lucsus, Lunds universitets centrum för studier av uthållig samhällsutveckling.

Local communities around the world are directly exposed to impacts of climatechange. It is also clear that many local governments are politically and economically constrained in their capacity to implement needed adaptations. These constraints can restrict adaptation options to incremental, or even maladaptive, practices. At the same time, necessary transformational actions may remain out of reach

Monthly precipitation data at regular grids of 0.5° × 0.5° derived from observations during June–August 1961–2016 were used to reveal characteristics of large‐scale circulations associated with rainy season precipitation over the source region of the Yangtze River (SRYR). The integrated impact of major influencing circulation patterns was examined by principal component analysis and composites. Re

High-grade serous ovarian cancer (HGSOC) is the most common subtype of epithelial ovarian cancer and early detection is challenging. TP53 mutations are a hallmark of HGSOC and detection of these mutations in liquid-based Pap samples could provide a method for early diagnosis. Here we evaluate the use of IBSAFE, an ultra-sensitive droplet digital PCR (ddPCR) method, for detecting TP53 mutations in

Background: Large animal models are important in atrial fibrillation (AF) research, as they can be used to study the pathophysiology of AF and new therapeutic approaches. Unlike other animal models, horses spontaneously develop AF and could therefore serve as a bona fide model in AF research. We therefore aimed to study the electrical, functional and structural remodelling caused by chronic AF in

The prompt fission γ-ray energy spectrum for cold-neutron-induced fission of U235 was measured in the energy range Eγ=0.8-20MeV, by gaining a factor of about 105 in statistics compared to the measurements performed so far. The spectrum exhibits local bump structures at Eγ≈4MeV and ≈6MeV, and also a broad one at ≈15MeV. In order to understand the origins of these bumps, the γ-ray spectra were calcu

Little is known about the variation within and among species of long-distance migrants in behavioural strategies and habitat choice on their non-breeding grounds. We report results from regular ringing operations carried out during the winter seasons 2009–2013 and transect counts in 2013, 2015 and 2016 in the Sudan Savanna Zone in Ghana. The best supported capture–mark–recapture model included spe

Quantum droplets may form out of a gaseous Bose-Einstein condensate, stabilized by quantum fluctuations beyond mean field. Determining the ground state of a rotating binary condensate, we show that multiple singly quantized vortices may form in these droplets at moderate angular momenta in two dimensions. Droplets carrying these precursors of an Abrikosov lattice remain self-bound for certain time

Emergency Medicine became a supraspeciality in Sweden in 2008. The Swedish Specialist Examination in Emergency Medicine is a formative examination that seeks to guide local training in Emergency Medicine, provide feedback to physicians during their residency, and establish national standards for various processes in Emergency Medicine. It consists of six partial examinations and 118 cases. Documen